Download Free Early Events Of Jaagsiekte Sheep Retrovirus Infection In The Ovine Lung Book in PDF and EPUB Free Download. You can read online Early Events Of Jaagsiekte Sheep Retrovirus Infection In The Ovine Lung and write the review.

Ovine pulmonary adenocarcinoma (OPA) is a contagious lung cancer of sheep, first reported in South Africa in 1832 as "jaagsiekte" (chasing sickness). Starting in the 1970s evidence began to accumulate that the etiologic agent of OPA is a retrovirus, culminating in the deduction of the sequence of a novel retrovirus associated with the disease, jaagsiekte sheep retrovirus (JSRV). Very recently, substantial progress has been made in JSRV research, including isolation of infectious and oncogenic molecular clones of JSRV, identification and cloning of the JSRV receptor, and demonstration that the envelope gene of JSRV functions as an oncogene. This book is a consensus volume that comprehensively reviews all aspects of JSRV research, including natural history of the disease, histopathology of OPA, molecular biology of JSRV, oncogenic transformation by JSRV, and comparison with human lung cancer.
Retroviruses have been of great importance to biomedical science for the past half century. Initially, studies on oncogenic animal retroviruses provided important insights into molecular processes in carcinogenesis – most notably the existence and mechanisms of action of oncogenes and proto-oncogenes. Moreover, several human diseases are caused by retroviruses, including AIDS, adult T-cell leukemia and the neurological disease HAM/TSP. The topic of this volume is a relatively unknown animal retrovirus, jaagsiekte sheep retrovirus, the causative agent of transmissible lung cancer in sheep –ovine pulmonary adenocarcinoma. The disease was first documented in South Africa in the 1800s, it has a wide geographical distribution, and it is of economic importance in high endemic regions. However, until very recently the nature of the etiologic agent was unclear, and relatively few laboratories actively studied the disease.
In recent years, a number of chronic diseases have been linked, in some cases definitively, to an infectious etiology: peptic ulcer disease with Helicobacter pylori, cervical cancer with several human papillomaviruses, Lyme arthritis and neuroborreliosis with Borrelia burgdorferi, AIDS with the human immunodeficiency virus, liver cancer and cirrhosis with hepatitis B and C viruses, to name a few. The proven and suspected roles of microbes does not stop with physical ailments; infections are increasingly being examined as associated causes of or possible contributors to a variety of serious, chronic neuropsychiatric disorders and to developmental problems, especially in children. The Infectious Etiology of Chronic Diseases: Defining the Relationship, Enhancing the Research, and Mitigating the Effects, summarizes a two-day workshop held by the Institute of Medicine's Forum on Microbial Threats to address this rapidly evolving field. Participants explored factors driving infectious etiologies of chronic diseases of prominence, identified difficulties in linking infectious agents with chronic outcomes, and discussed broad-based strategies and research programs to advance the field.
Encyclopedia of Virology, Fourth Edition, Five Volume Set builds on the solid foundation laid by the previous editions, expanding its reach with new and timely topics. In five volumes, the work provides comprehensive coverage of the whole virosphere, making this a unique resource. Content explores viruses present in the environment and the pathogenic viruses of humans, animals, plants and microorganisms. Key areas and concepts concerning virus classification, structure, epidemiology, pathogenesis, diagnosis, treatment and prevention are discussed, guiding the reader through chapters that are presented at an accessible level, and include further readings for those needing more specific information. More than ever now, with the Covid19 pandemic, we are seeing the huge impact viruses have on our life and society. This encyclopedia is a must-have resource for scientists and practitioners, and a great source of information for the wider public. Offers students and researchers a one-stop shop for information on virology not easily available elsewhere Fills a critical gap of information in a field that has seen significant progress in recent years Authored and edited by recognized experts in the field, with a range of different expertise, thus ensuring a high-quality standard
The Geographical Distribution of Animal Viral Diseases attempts to shed some light on the global distribution of 110 different viral diseases, mainly of livestock and companion animals. The world literature was screened for 110 different viruses, and maps were prepared. These maps delineate the global distribution of pathogenic viruses based on authenticated reports from a variety of reliable sources. Four viruses were categorized as affecting more than one species to a significant degree (astrovirus, rabies, rotaviruses, and Rift Valley fever). The largest number of maps involved viruses that affect humans. Of the 28 viruses a large number were from the California encephalitis group. Ten of the 28 viruses were reported only in the Eastern Hemisphere, 14 only in the Western Hemisphere, and four were worldwide. Birds were the next most frequently affected group with the 15 viruses, followed by pigs with 14 viruses. Overall the vector-borne viruses appear to have much sharper and clear-cut geographical boundaries than the others.
Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and metastasize. It also confers motility upon cells through interactions of cell-surface HA with the cytoskeleton. Embryonic cells in the process of movement and proliferation use the same strategy. It is an example of how cancer cells have commandeered normal cellular processes for their own survival and spread. There are also parallels between cancer and wound healing, cancer occasionally being defined as a wound that does not heal. The growing body of literature regarding this topic has recently progressed from describing the association of hyaluronan and hyaluronidase expression associated with different cancers, to understanding the mechanisms that drive tumor cell activation, proliferation, drug resistance, etc. No one source, however, discusses hyaluronan synthesis and catabolism, as well as the factors that regulate the balance. This book will offer a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer. - Offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer - Chapters are written by the leading international authorities on this subject, from laboratories that focus on the investigation of hyaluronan in cancer initiation, progression, and dissemination - Focuses on understanding the mechanisms that drive tumor cell activation, proliferation, and drug resistance
Lung cancer is a major cause of cancer-related deaths in men and women. However, since the first edition of Lung Cancer was published 14 years ago, rapid progress in the biology, prevention, diagnosis, and treatment of the disease has been made.
This book will contain a series of review articles that focus on retroviral models of human and animal cancers. Each article will be written by an expert in the field of retrovirology. The reviews will summarize current work on a particular retrovirus, with particular emphasis on the relevance of this research to human disease.
**Selected for Doody's Core Titles® 2024 in Veterinary Medicine** Get practical answers from the only guide on the care of sheep, goats, and cervids! Authoritative yet easy to read, Sheep, Goat and Cervid Medicine, 3rd Edition covers all the latest advances in the field, including diseases and medical treatment, surgery, pain management, theriogenology, and nutrition. Clear instructions and hundreds of full-color photographs guide you step by step through common procedures including restraint for examination, administration of drugs, blood collection, and grooming. New to this edition is coverage of deer and elk medicine, reflecting the growing interest in these ruminants. Written by an expert team led by Dr. D.G. Pugh, this comprehensive reference is ideal for veterinarians and also for owners of sheep and goats. - Clear writing style and consistent organization makes the book easy to understand and use, with disease chapters including pathogenesis, clinical signs, diagnosis, treatment, and prevention. - Coverage of both surgery and medicine in each body systems chapter makes it easier to choose between treatment options for specific disorders. - Superbly illustrated surgical procedures clearly demonstrate the steps to follow in performing medical and reproductive surgery. - Diverse, expert contributors include the most experienced authorities, each providing current information on the care of valuable breeding stock as well as pets. - Useful appendixes, now including veterinary feed directives, offer convenient access to information on drugs and drug dosages, fluid therapy, and normal values and conversions. - Consistent, logical format in each body systems chapter makes information easy to find by beginning with physical examination and diagnostic procedures, followed by discussions of common diseases that involve the system. - Comprehensive Feeding and Nutrition chapter covers diet evaluation, method of balancing rations, total parenteral nutrition, and examples of nutritious diets. - Explanation of the differences in normal behavior between sheep and goats shows how they are not the same, and require different methods of treatment. - NEW! Coverage of cervids has been added to chapters throughout the book, reflecting the growing popularity of deer and elk. - NEW! Thorough content updates are made throughout the book and reflect the latest research evidence. - NEW! 170 new clinical photos have been added. - NEW! Anesthesia and Pain Management chapter includes a new section on pain management strategies, reflecting the emphasis on controlling pain in small ruminants. - NEW! Expert Consult website offers an online version of the book, making it easy to search the entire book electronically. - NEW! Two new authors are respected and well-known veterinary medicine experts and educators: Dr. Misty Edmondson and Dr. Thomas Passler.