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Early Brain Damage, Volume 2: Neurobiology and Behavior, is the second of two volumes that provide a comprehensive overview of the many facets of research on the topic of brain damage sustained early in life. The present volume focuses on controlled experimentation on laboratory animals, and emphasizes the anatomical and physiological correlates of early brain-insult as well as the behavioral changes that may follow central nervous system damage early in life. This book is organized into three parts. Part I examines recent advances in anatomy and physiology, and covers topics such as axonal sprouting and changes in brain areas somewhat removed from the actual site of damage. Part II emphasizes current knowledge about the behavioral effects of specific lesions, such as those of the frontal or posterior cortical areas. Part III examines factors that can affect the response to early brain damage, including genetics, environmental conditions after early injury, and the differential effects resulting from sparing small fragments of a brain area. This book was written for researchers and professional personnel interested in the topic of brain damage, and especially toward those interested in the many developmental brain-damage issues emanating from laboratory animal studies and human case reports.
Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme
Early Brain Damage, Volume 1: Research Orientations and Clinical Observations, is the first of two volumes that provide a comprehensive overview of the many facets of research on the topic of brain damage sustained early in life. The present volume features a collection of chapters oriented toward early brain damage in human clinical populations. It is organized into four parts. Part I presents research strategies and theoretical issues, such as intermodal compensation and evolutionary considerations, relating to early brain-damage phenomena. Part II presents research on animal models of infant neuropathological conditions such as hypoxia, fetal radiation, locomotor hyperactivity, and attentional disorders. Part III is concerned with short-term and long-term neurological effects of brain damage in children, including chapters on perinatal asphyxia, behavioral consequences of cerebral insult sustained during infancy, and correlates of early generalized brain dysfunction in children. Part IV presents chapters on cerebral lateralization and higher-order functions as they are altered by early brain damage. This book was written for researchers and professionals interested in the topic of brain damage, and especially those interested in the developmental brain-damage issues emanating from laboratory animal studies and human case reports.
How does the genome, interacting with the multi-faceted environment, translate into the development by which the human brain achieves its astonishing, adaptive array of cognitive and behavioral capacities? Why and how does this process sometimes lead to neurodevelopmental disorders with a major, lifelong personal and social impact? This volume of Progress in Brain Research links findings on the structural development of the human brain, the expression of genes in behavioral and cognitive phenotypes, environmental effects on brain development, and developmental processes in perception, action, attention, cognitive control, social cognition, and language, in an attempt to answer these questions. Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Early Brain Damage, Volume 1: Research Orientations and Clinical Observations, is the first of two volumes that provide a comprehensive overview of the many facets of research on the topic of brain damage sustained early in life. The present volume features a collection of chapters oriented toward early brain damage in human clinical populations. It is organized into four parts. Part I presents research strategies and theoretical issues, such as intermodal compensation and evolutionary considerations, relating to early brain-damage phenomena. Part II presents research on animal models of infan ...
Greenfield's Neuropathology, the worlds leading neuropathology reference, provides an authoritative, comprehensive account of the pathological findings in neurological disease, their biological basis and their clinical manifestations. This account is underpinned throughout by a clear description of the molecular and cellular processes and reactions that are relevant to the development, and normal and abnormal functioning of, the nervous system. While this scientific content is of paramount importance, however, care has been taken to ensure that the information is presented in a way that is accessible to readers working within a range of disciplines in the clinical neurosciences, and that also places the neuropathological findings within the context of a broader diagnostic process. The new eighth edition incorporates much new information, new illustrations and many new authors, while retaining the depth, breadth and quality of content so praised in previous editions. Each chapter opens with an introductory section designed to offer an integrated approach to diagnosis, taking account of clinical manifestations, neuroradiological and laboratory findings as well as the neuropathological and molecular genetic features of the diseases being considered. Strong emphasis has been placed on facilitating the retrieval of neuropathological information by non-neuropathologists grapping with differential diagnoses or seeking information on broad categories of neurological disease, and boxes and tables are used to present important symptoms and signs, patterns of disease and other features for ease of reference. High quality line and photographic illustrations, the majority in full colour, are all available on a companion CD, to complete the offering.
Pediatric Surgery, 7th Edition - edited by Arnold G. Coran, Anthony Caldamone, N. Scott Adzick, Thomas M. Krummel, Jean-Martin Laberge, and Robert Shamberger - features comprehensive, up-to-date guidance on all aspects of childhood surgery, including congenital malformations, tumors, trauma, and urologic problems. Apply the latest developments in fetal surgery, adolescent bariatric surgery, minimally invasive surgery in children, and tissue engineering for the repair of congenital anomalies, such as the separation of conjoined twins. you can also access the fully searchable text online at www.expertconsult.com, making this definitive resource more accessible than ever. Get comprehensive coverage of cutting-edge technology in pediatric surgical diseases, including imaging concepts, minimally invasive techniques, robotics, diagnostic and therapeutic advances, and molecular biology and genetics. Find information quickly and easily with an intuitive organization by body region and organs. Apply the guidance of world-renowned experts in pediatric surgery. Access the fully searchable text online at www.expertconsult.com. Stay current on recent developments in fetal surgery, adolescent bariatric surgery, minimally invasive surgery in children, and tissue engineering for the repair of congenital anomalies, such as the separation of conjoined twins. Master the latest surgeries available for fetal and neonatal patients and provide life-saving options at birth. Tap into the expertise of new editors who bring fresh perspectives to cutting-edge techniques.
With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.