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Conceptually unsavoury, airway mucus is vital to homeostasis in the respiratory tract. In contrast, when abnormal, mucus contributes significantly to the pathophysiology of a number of severe bronchial diseases, including asthma, chronic bronchitis and cystic fibrosis. This volume provides wide ranging and in-depth coverage of the scientific and clinical aspects of airway mucus. It commences with introductory chapters which address the biochemical and molecular biological basis of airway mucus and continues with comprehensive coverage of the various physiological and rheological aspects of respiratory secretions. The clinical aspects of the topic are then considered, with chapters discussing the involvement of mucus secretions in bacterial infection and in hypersecretory diseases of the airway. The volume concludes with a discussion of the therapeutic aspects of the topic, both in terms of the possible approaches to the treatment of mucus hypersecretion and the interaction of these drugs with airway mucus. Written by leading experts in the field, each contribution provides a comprehensive review of its particular subject. Reflecting the latest advances in this important area of respiratory research, this volume will be of great interest to scientists and clinicians working in the field of airway secretions and related areas.
This reference book contains a comprehensive selection of the most frequently used assays for reliably detecting pharmacological effects of potential drugs, including tests for cardiovascular, analgesic, psychotropic, metabolic, endocrine, respiratory, renal, and immunomodulatory activities. Each of the over 700 assays comprises a detailed protocol with the purpose and rationale of the method, a description of the experimental procedure, a critical assessment of the results and their pharmacological and clinical relevance, and pertinent references. Identification of specific tests is facilitated by the enclosed CD-ROM which allows for a quick and full text research. An appendix with guidelines and legal regulations for animal experiments in various countries will help to plan these experiments properly in accordance with the welfare of laboratory animals.
The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments. Each chapter considers Asthma and COPD in side-by-side contrast and comparison - not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD Most extensive reference to primary literature on both Asthma and COPD in one source. Easy-to-read summaries of the latest advances alongside clear illustrations
-- Perfect for the student, primary care practitioner, and pharmacist who needs both basic and clinical information to apply therapeutics-- A new overview chapter -- plus practical steps required for optimal therapeutic decisions-- Coverage of newly emerging advances in therapeutics-- A new look at cost/benefit analysis of therapy-- Increased emphasis on drug interactions, and much more.
Written by nearly 60 of the world's leading investigators in this rapidly expanding field, this state-of-the-art reference furnishes detailed presentations on the basic science and clinical aspects of cilia, mucus, and mucociliary interactions. Providing stimulating coverage of the latest information in a single source, Cilia, Mucus, and Mucociliary Interactions discusses the genetic determinants of mucociliary system structure and function explains ciliary wave activity in cell-cell communication elucidates many of the key physiological processes in ciliary regulation reveals possible means of treating irregularities in mucus secretion and clearance improves understanding of clinical syndromes, including abnormalities pertaining to nasal sinuses, upper and lower airways, and the systemic role of cilia approaches the clinical management of mucociliary dysfunction logically using currently available diagnostic and therapeutic techniques and much more! Containing bibliographic citations, tables, equations, drawings, and photographs, this exhaustive guide is essential reading for physiologists, pulmonologists, otolaryngologists, pediatricians, microbiologists, basic scientists, and graduate and medical school students in these disciplines.
Now expanded and updated to include molecular biology and genetic engineering techniques. The second edition of this successful reference book contains a comprehensive selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Each of the more than 1000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. The enclosed and fully searchable CD ROM allows easy identification of specific tests. An appendix with up-to-date guidelines and legal regulations for animal experiments in various countries will help the reader to plan experiments more effectively.
Although the mechanisms and triggers that stimulate and are responsible for the natural history ofasthma are steadily being more clearly defined, uncertainties still surround both the genetic basis and the etiologyofone of the most common syndromes in the world. In fact, it is ofconsider able concern and interest that the incidence of asthma today appears to be rising. These statistical increments may only reflect an increasing awareness of the disease, or its earlier and more sophisticated diagnosis. More important, however, asthma mortality appears to be increasing. This increase has occurred despite the continuing expansion of a diag nostic and management information base, and the developmentofnovel andevermoreeffective therapeutic modalities. Severalexplanations have been offered for this increase in mortality, including that it may result from a statistical artifact [based on a change in the coding criteria for asthma from the International ClassificationofDiseases Version 8(ICD 8) to ICD-9], worsened pollution, delays in seeking medical help, behav ioral changes, deficits in the asthma education of both patients and primary careproviders, toxicity ofbeta-agonists, and noncompliance with instructions for the proper use of medications. It should also be empha sized that the increases in both incidence and mortality may be a reflec tion of accumulating body burdens of environmental toxicants and of increased oxidativedamage. There has clearly beenadegradation ofenvi ronmental quality. And although considerableattention has been focused on this possibility in both the scientific and lay press, more research in this area is definitely needed.
Written as a concise clinical reference guide covering the current and future airway disease treatments, this text encompasses: pathophysiology of respiratory tract diseasesthe methods of measuring airway and clinical responsesthe concepts upon which many treatments are used in COPD and asthma conditionsthe way in which these treatments work,
A concise overview of some of the findings and topics related to the pharmacology and clinical applications of traditional herbal therapeutics. It addresses the current and potential roles for herbal medicine in the context of our evolving health-care systems. Introducing many pharmacological advances made, the work also describes the modern theories and scientific methodologies applied to today's studies on herbal medicines and new drug development.