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Now completely up-to-date with the latest research advances, the Seventh Edition retains the distinctive character of earlier editions. Twenty-two concise chapters, co-authored by six highly distinguished biologists, provide current, authoritative coverage of an exciting, fast-changing discipline.
Unraveling the Double Helix covers the most colorful period in the history of DNA, from the discovery of "nuclein" in the late 1860s to the publication of James Watson's The Double Helix in 1968. These hundred years included the establishment of the Nobel Prize, antibiotics, x-ray crystallography, the atom bomb and two devastating world wars—events which are strung along the thread of DNA like beads on a necklace. The story of DNA is a saga packed with awful mistakes as well as brilliant science, with a wonderful cast of heroes and villains. Surprisingly, much of it is unfamiliar. The elucidation of the double helix was one of the most brilliant gems of twentieth century science, but some of the scientists who paved the way have been airbrushed out of history. James Watson and Francis Crick solved a magnificent mystery, but Gareth Williams shows that their contribution was the last few pieces of a gigantic jigsaw puzzle assembled over several decades.The book is comprehensive in scope, covering the first century of the history of DNA in its entirety, including the eight decades that have been neglected by other authors. It also explores the personalities of the main players, the impact of their entanglement with DNA, and what unique qualities make great scientists tick.
Written by a noted historian of science, this in-depth account traces how Watson and Crick achieved one of science's most dramatic feats: their 1953 discovery of the molecular structure of DNA.
An autobiographical account of Jim Watson's life, following on from The Double Helix, the story of his and Francis Crick's discovery of the structure of DNA (published in 1968). Here is Watson adjusting to new-found fame, carrying out tantalizing experiments and falling in love.
Chapters cover such topics as the theories of Darwin, Mendel, and Barbara McClintock, quantum chemistry, and the molecules of life.
Since its publication in 1968, The Double Helix has given countless readers a rare and exciting look at one highly significant piece of scientific research-Watson and Crick's race to discover the molecular structure of DNA.
The problem of unraveling two intertwined strands during the duplication of DNA was recognized shortly after the proposal of the DNA double helix structure in 1953. A group of enzymes called DNA topoisomerases solve this problem by breaking and rejoining DNA molecules in a controlled manner, thereby allowing strands to be passed through each other and thus untangled—not just during DNA replication, but also during many other basic cellular processes. Because of their intimate involvement in the workings of the cell, topoisomerases are also the logical targets of many antibiotics (including Cipro) and anticancer agents. This book, written by James Wang, the discoverer of the first topoisomerase and a leader in the field since, presents ten chapters covering the historical backdrop of the DNA entanglement problem and the discovery of the DNA topoisomerases, how DNA topoisomerases perform their magic in DNA replication, transcription, genetic recombination and chromosome condensation, and how they are targets of therapeutic agents. The book should appeal to readers from undergraduates upwards with interests in the biological and clinical aspects of topoisomerase function, or in the mathematics and physics of topology.
Would you want to know what awaits you? Would you want to be in control of your life . . . and death? What would you do for love? 'Sooner or later, willingly or unwillingly, he’s going to leave you.' The words cut deep. Emily knows Jake is not like his father; he’d never leave her willingly. But if he has inherited his mother's genes, then Huntington’s disease is more than likely to take him away. He may even make the same request his mother made, when Jake was still a teenager: to end the suffering for good.