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This book is intended for non-specialists and students, presenting a unique introduction to the field of DNA nanotechnology. The primary focus is on the extraordinary advantages of specificity and sensitivity obtained by integrating DNA nanostructures in bioanalytical devices.DNA Nanotechnology for Bioanalysis provides a concise and rigorous description for the fabrication of various types of functional nanostructures by optimized software-aided high-yield synthesis. Following this is the explanation of methods to decorate these nanostructures with molecules such as proteins, metal nanoparticles or bioorganic moieties covalently bonded onto DNA via self-assemblage processes. Also provided is a concise review on non-canonical DNA structures (such as G-quadruplexes) and their targeting by small molecules for applications in pharmacology. Finally, it describes the exciting applications of DNA nanostructures in life sciences and nanomedicine, including ultraspecific molecular delivery, control of cell behavior, analysis of cell lysate and DNA-based nano-tools for super-resolution sub-cellular imaging.
This book introduces the reader the chemistry of reaction approaches by which noble metal nanoparticles are synthesized, including synthetic approaches using the Brust–Schiffrin method , a high-temperature solution-phase synthesis, polymer and biological entities, weak and strong reducing and capping agents, the low and high temperatures, various additives and various novel approaches such as plasma, ionic liquids, UV light and gamma rays and others. This book starts with a brief overview of foundation work concerned with the chapter topics such as nanomaterials, nanoscience, surface-capping molecules, traditional and nontraditional reduction agents, In addition, chemical and physical properties of noble metal nanoparticles with different structures and elements such as monolayered clusters, nanorods, and bimetallic nanoparticles are described comprehensively. The aim is to summarize the fundamentals and mechanistic approaches in the preparation and characterization of metal colloidal nanoparticles and dispersions. In this way the reader is provided with a systematic and coherent picture of the interesting field of nanoscience based on noble metal colloidal nanoparticles. Intended as a wide-ranging overview, the book is a resource for novices in the field as well as for specialists, particularly those scientists working in the area of nanoparticle synthesis. Nanoscience and nanotechnology are discussed from the chemist’s point of view. Therefore, this volume describes in detail the terms, definitions, theories, experiments, and techniques dealing with the synthesis of noble metal nanoparticles. The material presented here is essential reading for research chemists, technologists, and engineers in the fields of specialty nanomaterials and metal industries, and also is highly valuable for researchers in university, institutional, and governmental laboratories, especially for those at advanced stages of their careers.
An introduction to the science of nanoparticles, from fundamental principles to their use in novel applications. As a basis for understanding nanoparticle behavior, the book first outlines the principles of quantum size behavior, nanoparticles architecture, formation of semiconductor and metal nanoparticles. It then goes on to describe the chemical syntheses of nanoparticles with defined characteristics, their structural, electrical and magnetic properties, as well as current methods to monitor these properties. Among others, the following nanoparticle-based applications are discussed: Single-electron devices Ultra dense recording media Bioelectronic devices and sensors Labeling of proteins, nucleic acids and other biomaterials. With its clear structure and comprehensive coverage, backed by numerous examples from the recent literature, this is a prime reference for chemists and materials scientists working with and developing nanoparticle systems.
This book describes the fundamental concepts, the latest developments and the outlook of the field of nanozymes (i.e., the catalytic nanomaterials with enzymatic characteristics). As one of today’s most exciting fields, nanozyme research lies at the interface of chemistry, biology, materials science and nanotechnology. Each of the book’s six chapters explores advances in nanozymes. Following an introduction to the rise of nanozymes research in the course of research on natural enzymes and artificial enzymes in Chapter 1, Chapters 2 through 5 discuss different nanomaterials used to mimic various natural enzymes, from carbon-based and metal-based nanomaterials to metal oxide-based nanomaterials and other nanomaterials. In each of these chapters, the nanomaterials’ enzyme mimetic activities, catalytic mechanisms and key applications are covered. In closing, Chapter 6 addresses the current challenges and outlines further directions for nanozymes. Presenting extensive information on nanozymes and supplemented with a wealth of color illustrations and tables, the book offers an ideal guide for readers from disparate areas, including analytical chemistry, materials science, nanoscience and nanotechnology, biomedical and clinical engineering, environmental science and engineering, green chemistry, and novel catalysis.
Nanotechnology provides tools for creating functional materials, devices, and systems by controlling materials at the atomic and molecular scales and making use of novel properties and phenomena. Nanotechnology-enabled sensors find applications in several fields such as health and safety, medicine, process control and diagnostics. This book provides the reader with information on how nanotechnology enabled sensors are currently being used and how they will be used in the future in such diverse fields as communications, building and facilities, medicine, safety, and security, including both homeland defense and military operations.
Written by international experts describing the various facets of nanofabrication, the ten volumes of this series cover the complete range of synthetic methods, tools and techniques being developed towards medical, biological and cybernetic applications. This volume covers the synthetic and materials aspects of instilling biocompatibility into nanomaterials with properties desirable for advanced medical and biological applications.
Following an introduction to biogenic metal nanoparticles, this book presents how they can be biosynthesized using bacteria, fungi and yeast, as well as their potential applications in biomedicine. It is shown that the synthesis of nanoparticles using microbes is eco-friendly and results in reproducible metal nanoparticles of well-defined sizes, shapes and structures. This biotechnological approach based on the process of biomineralization exploits the effectiveness and flexibility of biological systems. Chapters include practical protocols for microbial synthesis of nanoparticles and microbial screening methods for isolating a specific nanoparticle producer as well as reviews on process optimization, industrial scale production, biomolecule-nanoparticle interactions, magnetosomes, silver nanoparticles and their numerous applications in medicine, and the application of gold nanoparticles in developing sensitive biosensors.
Containing cutting edge research on the hot topic of nanobiosensor, this book will become highly read Biosensor research has recently re-emerged as most vibrant area in recent years particularly after the advent of novel nanomaterials of multidimensional features and compositions. Nanomaterials of different types and striking properties have played a positive role in giving the boost and accelerated pace to biosensors development technology. Nanobiosensors - From Design to Applications covers several aspects of biosensors beginning from the basic concepts to advanced level research. It will help to bridge the gap between various aspects of biosensors development technology and applications. It covers biosensors related material in broad spectrum such as basic concepts, biosensors & their classification, biomarkers & their role in biosensors, nanostructures-based biosensors, applications of biosensors in human diseases, drug detection, toxins, and smart phone based biosensors. Nanobiosensors - From Design to Applications will prove a source of inspiration for research on biosensors, their local level development and consequently using for practical application in different industries such as food, biomedical diagnosis, pharmaceutics, agriculture, drug discovery, forensics, etc. * Discusses the latest technology and advances in the field of nanobiosensors and their applications in human diseases, drug detection, toxins * Offers a broad and comprehensive view of cutting-edge research on advanced materials such as carbon materials, nitride based nanomaterials, metal and metal oxide based nanomaterials for the fast-developing nanobiosensors research * Goes to a wide scientific and industry audience Nanobiosensors - From Design to Applications is a resource for polymer chemists, spectroscopists, materials scientists, physical chemists, surface chemists, and surface physicists.
This detailed volume presents a comprehensive technical overview of DNA nanotechnology with an emphasis on 3D DNA nanostructure design and applications. Coverage spans from basic design principles for DNA and RNA nanostructures to their cutting-edge applications in a variety of fields, with the book divided into basic DNA and RNA nanostructure design strategies as well as applications utilizing DNA nanostructures, including but not limited to nanomedicine, bioimaging, biosensing, nanoplasmonics, nanoelectronics, nanofabrication, crystallography, biophysics, and analytical chemistry. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, 3D DNA Nanostructure: Methods and Protocols provides the most up-to-date tutorial style overviews and technical style protocols to benefit researchers in a wide variety of areas.