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This is the first book portraying to a wide readership many fields of DNA in the world of materials altogether in a single volume. The book provides underlying concepts and state-of-art developments in the emerging fields of DNA electronics, structural DNA nanotechnology, DNA computing and DNA data storage, DNA machines and nanorobots. Future possibilities of innovative DNA-based technologies, such as DNA cryptography, DNA identity tags, DNA nanostructures in biosensing and nanomedicine, as well as DNA-based nanoelectronics are all covered, too. This book is valuable for university students studying engineering and technology; biotech, nanotech, and medical device R&D managers, practitioners and investors; and IP analysts who would like to extend their background in advanced DNA technologies. It is nicely illustrated, which makes it very readable, and it conveys science and principles in a lively language to appeal to a broad audience, from professionals and academics to students and lay readers. Advance Praise for DNA Beyond Genes: “Most students of DNA, and lay readers as well, are interested in the absolutely essential role it plays in biology. However, the properties which make DNA the carrier of genetic information also make it an extraordinary material that can be used as the backbone for a wide variety of nanoengineering applications – these range from information storage and computation to molecular machines and devices to artfully designed logos and symbols. The perfect self-recognition of DNA sequences makes it an ideal building block to synthesize more and more elaborate constructions and imaginative scientists have probably only just scratched the surface of what can eventually be created. Here for the first time in this wonderful book Vadim Demidov explores the full range of the non-biological applications of DNA.” Charles R. Cantor Professor Emeritus of Biomedical Engineering, Boston University Member of the USA National Academy of Sciences
Epigenetics is currently one of the fastest-growing fields in the sciences. Epigenetic information not only controls DNA expression but links genetic factors with the environmental experiences that influence the traits and characteristics of an individual. What we eat, where we work, and how we live affects not only the activity of our genes but that of our offspring as well. This discovery has imposed a revolutionary theoretical shift on modern biology, especially on evolutionary theory. It has helped to uncover the developmental processes leading to cancer, obesity, schizophrenia, alcoholism, and aging, and to facilitate associated medial applications such as stem cell therapy and cloning. Above the Gene, Beyond Biology explores how biologists in this booming field investigate and explain living systems. Jan Baedke offers the first comprehensive philosophical discussion of epigenetic concepts, explanations, and methodologies so that we can better understand this “epigenetic turn” in the life sciences from a philosophical perspective.
What is Life? Decades of research have resulted in the full mapping of the human genome - three billion pairs of code whose functions are only now being understood. The gene's eye view of life, advocated by evolutionary biology, sees living bodies as mere vehicles for the replication of the genetic codes. But for a physiologist, working with the living organism, the view is a very different one. Denis Noble is a world renowned physiologist, and sets out an alternative view to the question - one that becomes deeply significant in terms of the living, breathing organism. The genome is not life itself. Noble argues that far from genes building organisms, they should be seen as prisoners of the organism. The view of life presented in this little, modern, post-genome project reflection on the nature of life, is that of the systems biologist: to understand what life is, we must view it at a variety of different levels, all interacting with each other in a complex web. It is that emergent web, full of feedback between levels, from the gene to the wider environment, that is life. It is a kind of music. Including stories from Noble's own research experience, his work on the heartbeat, musical metaphors, and elements of linguistics and Chinese culture, this very personal and at times deeply lyrical book sets out the systems biology view of life.
A top behavioral geneticist argues DNA inherited from our parents at conception can predict our psychological strengths and weaknesses. This “modern classic” on genetics and nature vs. nurture is “one of the most direct and unapologetic takes on the topic ever written” (Boston Review). In Blueprint, behavioral geneticist Robert Plomin describes how the DNA revolution has made DNA personal by giving us the power to predict our psychological strengths and weaknesses from birth. A century of genetic research shows that DNA differences inherited from our parents are the consistent lifelong sources of our psychological individuality—the blueprint that makes us who we are. Plomin reports that genetics explains more about the psychological differences among people than all other factors combined. Nature, not nurture, is what makes us who we are. Plomin explores the implications of these findings, drawing some provocative conclusions—among them that parenting styles don't really affect children's outcomes once genetics is taken into effect. This book offers readers a unique insider’s view of the exciting synergies that came from combining genetics and psychology.
In light of scientific advances such as genomics, predictive diagnostics, genetically engineered agriculture, nuclear transfer cloning, and the manipulation of stem cells, the idea that genes carry predetermined molecular programs or blueprints is pervasive. Yet new scientific discoveries—such as rna transcripts of single genes that can lead to the production of different compounds from the same pieces of dna—challenge the concept of the gene alone as the dominant factor in biological development. Increasingly aware of the tension between certain empirical results and interpretations of those results based on the orthodox view of genetic determinism, a growing number of scientists urge a rethinking of what a gene is and how it works. In this collection, a group of internationally renowned scientists present some prominent alternative approaches to understanding the role of dna in the construction and function of biological organisms. Contributors discuss alternatives to the programmatic view of dna, including the developmental systems approach, methodical culturalism, the molecular process concept of the gene, the hermeneutic theory of description, and process structuralist biology. None of the approaches cast doubt on the notion that dna is tremendously important to biological life on earth; rather, contributors examine different ideas of how dna should be represented, evaluated, and explained. Just as ideas about genetic codes have reached far beyond the realm of science, the reconceptualizations of genetic theory in this volume have broad implications for ethics, philosophy, and the social sciences. Contributors. Thomas Bürglin, Brian C. Goodwin, James Griesemer, Paul Griffiths, Jesper Hoffmeyer, Evelyn Fox Keller, Gerd B. Müller, Eva M. Neumann-Held, Stuart A. Newman, Susan Oyama, Christoph Rehmann-Sutter, Sahotra Sarkar, Jackie Leach Scully, Gerry Webster, Ulrich Wolf
The past few years have seen a revolution in our ability to map whole genome DNA from ancient humans. With the ancient DNA revolution, combined with rapid genome mapping of present human populations, has come remarkable insights into our past. This important new data has clarified and added to our knowledge from archaeology and anthropology, helped resolve long-existing controversies, challenged long-held views, and thrown up some remarkable surprises. The emerging picture is one of many waves of ancient human migrations, so that all populations existing today are mixes of ancient ones, as well as in many cases carrying a genetic component from Neanderthals, and, in some populations, Denisovans. David Reich, whose team has been at the forefront of these discoveries, explains what the genetics is telling us about ourselves and our complex and often surprising ancestry. Gone are old ideas of any kind of racial 'purity', or even deep and ancient divides between peoples. Instead, we are finding a rich variety of mixtures. Reich describes the cutting-edge findings from the past few years, and also considers the sensitivities involved in tracing ancestry, with science sometimes jostling with politics and tradition. He brings an important wider message: that we should celebrate our rich diversity, and recognize that every one of us is the result of a long history of migration and intermixing of ancient peoples, which we carry as ghosts in our DNA. What will we discover next?
Happiness Genes proves that there is a definitive link between science and spirituality--that you are biologically wired for natural happiness. You have a constitutional right to "life, liberty, and the pursuit of happiness." And every day thousands of advertising images seduce you into believing that happiness can be bought. Put away your wallet. Happiness is at your fingertips--it's sitting right in your DNA. The new science of epigenetics reveals that there are reserves of natural happiness within your DNA that can be controlled by you, your emotions, beliefs, and your behavioral choices. Happiness Genes: Unlock the Positive Potential Hidden in Your DNA examines the nature and source of happiness, from ancient times to the present. It presents the epigenetic and other biological research that shows that DNA contains genes for natural happiness and your ultimate well-being. Then it details the 28-Day natural happiness program--you'll learn how to "switch on" your happiness genes, creating a biological cascade of well-being.
"An indispensable resource for understanding the complex world of over-the-counter genetic testing ... the impressive book explores territory that is both easy to understand and enlightening." --Kirkus Review "Highly important, life-changing and delightfully written...[Pistoi] is pulling the rug out from under many of our preconceptions...with continuous wit and humor. A book which indeed demands to be savored." --Paul Levinson, author of The Silk Code and The Plot to Save Socrates “DNA Nation is a highly readable, scientifically accurate, guide to the brave new world of consumer genetic testing. A must for anyone intrigued by ancestry, health, and the grand variety of humankind”. --Ricki Lewis, author of Human Genetics and The Forever Fix “An enjoyable foray into the medical, legal and ethical aspects of the ongoing genetic revolution…a fun and important read guided by one of the nation's most gifted science writers.” --Jacob M. Appel, author of Who Says You're Dead Millions of people have done it: with a few clicks and some spit, and at less than the cost of a fancy dinner, you can buy a reading of your DNA online. With this in hand, you can find out where you came from, trace relatives around the world and find new friends on a genetic social network. You can learn about your predisposition to disease, get a genetically tailored diet, understand the sports to which you or your children might be more suited, and even find a date. It’s the dawn of consumer genomics, where the progress of biology meets the power of the Internet and big data. But do these applications work? Can we really prevent diseases based on what we read in our DNA? What do scientists say? And do we really understand the implications? What happens if things go wrong and the data is misused or the trust abused? Sergio Pistoi, a journalist and a DNA scientist, investigated this brave new world first-hand by interrogating his own genes, and has provided a practical, informative and thought-provoking survival guide to home genetic testing. From medicine to food, from social networking to genealogy and advertising, this book will show you how the DNA revolution is beginning to have such a profound impact on our daily lives and privacy and why it will influence the choices we make. If you are interested in how social media meets cutting-edge science, and what it means for your life, or if you are considering buying a DNA test, then this is the book for you.
We can change the world with gene editing—but should we? CRISPR stands for clustered regularly interspaced short palindromic repeats. If it sounds complicated, it is—but it’s also one of the most powerful ways we can shape the future. And it’s poised to completely upend the way we think about science. Author Yolanda Ridge tackles this topic in a friendly and accessible tone, with two introductory chapters covering the basics of DNA and gene editing before taking readers through the ways that this ground-breaking science could affect them by potentially: • eliminating diseases like malaria and cancer, • improving the stability of our food supply, and • helping to manage conservation efforts for threatened animals and environments. But all of these possible advancements come with risks, the biggest being that the consequences are unknown. Chapters end with “Stop, Go, Yield” sections encouraging readers to consider the pros and cons of using CRISPR. “Cutting Questions” give readers the opportunity to further reflect on the ethics of the science. CRISPR is a game changer. This important book, with detailed scientific illustrations, brings much needed clarity to a topic that will affect readers for generations to come. *A Junior Library Guild Gold Standard Selection