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This book provides the reader with comprehensive information on the epidemiology, etiology, pathogenesis, pathophysiology, clinical features, prevention, and treatment of diabetes with the aim of empowering health care providers in their daily battle against the disease. Diabetes has been identified by WHO and the United Nations as a medical emergency because of the increase in its global prevalence, which may reach one billion in three to four decades if the trend remains unchanged. Despite improved care that is helping to prolong life, diabetes impacts substantially on the quality of life of those affected and kills or disables several million people each year. The disease is systemic because all organs, tissues, and cells suffer in the presence of hyperglycemia and are damaged by the diabetic milieu. Unfortunately, most patients with diabetes will consequently experience chronic diabetic complications. This book, combining basic science with a practical clinical orientation, will be of value for all physicians and nurses who care for patients with diabetes.
The management of type 2 diabetes in children and adolescents is complex and poses a range of unique challenges. Treatment may involve weight reduction, lifestyle modification, exercise programs, and medications to treat hyperglycemia. However, few of the drugs used in the treatment of type 2 diabetes and even fewer of those used to reduce the risk of cardiovascular disease have been licensed for use in children and adolescents. A state-of-the-art resource, this book provides a comprehensive review of current research and developments. International experts address the interrelationship of diabetes, obesity, insulin resistance and the metabolic syndrome; the spectrum of clinical features and diagnostic issues; the epidemiology, pathophysiologic basis, genetics of this disorder; and its treatment in children and adolescents.
Diabetes mellitus is a very common disease which affects approximately 150,000,000 worldwide. With its prevalence rising rapidly, diabetes continues to mystify and fascinate both practitioners and investigators by its elusive causes and multitude of This textbook is written for endocrinologists, specialists in other disciplines who treat diabetic patients, primary care physicians, housestaff and medical students. It covers, in a concise and clear manner, all aspects of the disease, from its pathogenesis on the molecular and cellular levels to its most modern therapy.
This comprehensive text is unique in its compilation of experiences in addressing the global diabetes epidemic and description of diverse worldwide prevention initiatives. Background chapters describe the diagnosis and definition of diabetes, the epidemiology, pathophysiology of prediabetes as well as clinical trial evidence for diabetes prevention and treatment. Furthermore, the critical role of government in formulating a global health agenda, policy perspectives for European initiatives, the importance of nutritional policies for diabetes prevention as well as the development of the necessary capacity and infrastructure for diabetes prevention are described. Given the prevalence of diabetes in South Asians and migrants, one chapter focuses on risk factors and prevention of diabetes in these communities. Other chapters detail local and regional approaches covering a truly global span: United States, Latin America, Europe, India, Turkey, (Siberia) Russia, the Middle East and North Africa, South Africa, Israel, East Asia and Australia.Authored by academic experts in endocrinology and diabetes and global leaders in epidemiology and public health, this landmark text is an authoritative reference for a diverse audience including government, public health and policy experts and researchers, academicians, healthcare professionals, endocrinologists and clinicians interested in prediabetes and diabetes prevention, graduate students and faculty in public and global health graduate programs, epidemiologists, nutritionists, sociologists and those in translational medicine. Readers will broaden their awareness of the prevailing and burgeoning diabetes epidemic and the remarkably creative worldwide prevention initiatives undertaken to address the seemingly insurmountable inherent challenges posed by this global health care crisis. The text is an attestation to the wonderful potential for enormous human collaboration and achievement when communal organizations, governments at local, regional and national levels, researchers, the medical and public health communities, and nutrition experts join with global citizenry in confronting one of the most significant healthcare challenges witnessed in this century.
Diabetes: Epidemiology, Pathophysiology and Clinical Management aims to be the one-stop diabetes book for researchers, scientists and clinicians. It details the epidemiology, causes, molecular mechanisms, molecular markers, available drugs, experimental drugs, treatment modalities, and dietary and lifestyle approaches related to diabetes. It focuses on various molecular aspects of diabetes, and its related co-morbidities. Apart from the drug-based treatment approach based on international guidelines, this book also describes various surgical treatments available for cases of uncontrolled symptomatic diabetes. It also lays emphasis on the future possibilities of different approaches for diabetes management. Key Features Includes treatment guidelines and approaches to diabetes provided by major global diabetes associations Provides a thorough and comprehensive assimilation of detailed information and updates in the field of diabetes, helpful for researchers, scientists and clinicians Contains a chapter on anti-diabetic drugs, that covers both the commercially approved drugs as well as those that are in various phases of experimental, pre-clinical, and clinical trials
"Principles of Diabetes Mellitus, Second Edition" is an important update to the comprehensive textbook first published in 2002 and reissued in 2004. It is written for physicians of all specialties who, on a daily basis, deal with an illness which has reached epidemic proportions. The book is also intended for medical students and investigators of all aspects of diabetes. The last five years have witnessed major developments in our understanding of diabetes and in therapeutic approaches to this disease. Thus, in addition to updating all chapters, the authors added eight new chapters to the second edition. "Principles of Diabetes Mellitus, Second Edition" covers diabetes in all of its aspects – genetics, epidemiology, pathophysiology, clinical manifestations, therapy and prevention.
As a consequence of the obesity epidemic, the prevalence of type 2 diabetes in children and adolescents is increasing. For medical trend watchers and health care professionals alike, this groundbreaking book covers epidemiology of type 2 diabetes in youth; pathophysiology of type 2 in youth; case-finding criteria; early recognition of risk factors; prevention of obesity in this population; and more.
Although pancreas transplants have been performed for more than 30 years, the last few years have witnessed significant growth in the options available for pancreas transplantation as well as subtantial improvements in outcome. It is therefore appropriate that a new text summarize the recent advances and put forth the standard of future care. Transplantation of the Pancreas, edited by Drs. Gruessner and Sutherland fulfills this mission by providing a state-of-the-art, definitive reference work on pancreas transplantation for transplant surgeons and physicians as well as for endocrinologists, diabetologists, nephrologists, and neurologist. The editors, from the renowned University of Minnesota Transplant Division and the Diabetes Institute, have assembled a group of renowned experts to provide an all inclusive overview of pancreas transplantation. The text features insights on the pathophysiology of diabetes mellitus and the limitations of nontransplant treatments, highlights experimental research and clinical history of pancreas transplantation, and compares and contrasts different surgical procedures. The discussions detail the broad spectrum of posttransplant complications and their treatments, which frequently require skills in general, vascular, and laparoscopic surgery, interventional radiology, critical care, and infectious disease. Chapters on immunosuppression, immunology, pathology, long-term outcome, quality of life, and cost-effectiveness focus on issues unique to pancreas recipients. Evolving areas, such as pretransplant evaluation of pancreas transplant candidates, living donation, and the current status of islet transplantation are discussed. Augmented by more than 280 illustrations, including full color line drawings created exclusively for the text, this book is the standard reference for all transplant professionals as well as all physicians caring for diabetic patients.