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This book describes the development of three dimensional electroactive fibres using a novel coaxial wet-spinning approach from organic conductors in combination with non-conducting hydrogel polymers. This book also presents the characterization and evaluation of multiaxial biofibres in terms of mechanical, physical, electrochemical and biological properties, and explores their use in a diverse range of applications including implantable electrodes, drug delivery systems and energy-storage systems. In the first chapter, the author highlights the significance of engineering three dimensional fibres, introduces the involved hydrogels and organic conductors with emphasis on their biomedical application, and collects some of the previously established methods for fabrication of biofibres. In the second chapter, particular attention is given to the overall experimental fabrication methods and characterization analyses conducted in the work. Chapters three to five present the main findings of this work, in which readers will discover how novel hybrid hydrogel fibres with an inner core of chitosan and alginate were prepared and characterized, how graphene was incorporated into coaxial wet-spun biofibres, and how one-dimensional triaxial fibres were developed using a novel coaxial wet-spinning fibre production method and applied as potential battery devices. In the final chapter of this work, the author summarizes the main achievements of the work and outlines some recommendations for future research.
This new important book is a collection of research and review articles from different parts of the world discussing the dynamic and vibrant field of hydrogels. The articles are linking new findings and critically reviewing the fundamental concepts and principles that are making the base for innovation. Each chapter discusses the potential of hydrogels in diverse areas. These areas include tissue engineering, implants, controlled drug release, and oil reserve treatment. The book is offering an up-to-date knowledge of hydrogels to experienced as well as new researchers.
Cellulose nanoparticles (CNP) are a class of bio-based nanoscale materials, which are of interest due to their unique structural features and properties such as biocompatibility, biodegradability, and renewability. They are promising candidates for applications including in biomedicine, pharmaceuticals, electronics, barrier films, nanocomposites, membranes, and supercapacitors. New resources, extraction procedures and treatments are currently under development to satisfy increasing demands for cost-effective and sustainable methods of manufacturing new types of cellulose nanoparticle-based materials on an industrial scale. Cellulose Nanoparticles: Chemistry and Fundamentals covers the synthesis, characterization and processing of cellulose nanomaterials. It aims to address the recent progress in the production methodologies for cellulose nanoparticles, covering principal cellulose resources and the main processes used for isolation. Chapters cover the preparation and characterisation of cellulose nanocrystals and nanofibrils. Together with Volume 2, these books form a useful reference work for graduate students and researchers in chemistry, materials science, nanoscience and green nanotechnology.
Cellulose Nanoparticles: Chemistry and Fundamentals covers the synthesis, characterization and processing of cellulose nanomaterials.
Multifunctional Hydrogels for Biomedical Applications Comprehensive resource presenting a thorough overview of the biomedical applications of hydrogels This book provides an overview of the development and applications of the clinically relevant hydrogels that are used particularly in tissue engineering, regenerative medicine, and drug delivery. Taking a multidisciplinary approach, it goes through the material from chemistry, materials science, biology, medicine, nanotechnology, and bioengineering points of view. Sample topics covered by the three well-qualified editors include: The design, functions, and developments of hydrogels Proteins and polysaccharides that mimic extracellular matrix Generation and applications of supramolecular hydrogels Design and functions of cell encapsulation systems Multifunctional Hydrogels for Biomedical Applications is a useful all-in-one reference work for materials scientists, polymer chemists, and bioengineers which provides a comprehensive, contemporary understanding of hydrogels and their applications targeting a wide variety of pathologies.
An authoritative resource that offers an understanding of the chemistry, properties and applications of temperature-responsive polymers With contributions from a distinguished panel of experts, Temperature-Responsive Polymers puts the focus on hydrophilic polymers capable of changing their physicochemical properties in response to changes in environmental temperature. The contributors review the chemistry of these systems, and discuss a variety of synthetic approaches for preparation of temperature-responsive polymers, physicochemical methods of their characterisation and potential applications in biomedical areas. The text reviews a wide-variety of topics including: The characterisation of temperature-responsive polymers; Infrared and Raman spectroscopy; Applications of temperature-responsive polymers grafted onto solid core nanoparticles; and much more. The contributors also explore how temperature-responsive polymers can be used in the biomedical field for applications such as tissue engineering. This important resource: Offers an important synthesis of the current research on temperature-responsive polymers Covers the chemistry, the synthetic approaches for presentation and the physiochemical method of temperature-responsive polymers Includes a review of the fundamental characteristics of temperature-responsive polymers Explores many of the potential applications in biomedical science, including drug delivery and gene therapy Written for polymer scientists in both academia and industry as well as postgraduate students working in the area of stimuli-responsive materials, this vital text offers an exploration of the chemistry, properties and current applications of temperature-responsive polymers.
The use of medical devices (e.g., catheters, implants, and probes) is a common and essential part of medical care for both diagnostic and therapeutic purposes. However, these devices quite frequently lead to the incidence of infections due to the colonization of their abiotic surfaces by biofilm-growing microorganisms, which are progressively resistant to antimicrobial therapies. Several methods based on anti-infective biomaterials that repel microbes have been developed to combat device-related infections. Among these strategies, surface coating with antibiotics (e.g., beta-lactams), natural compounds (e.g., polyphenols), or inorganic elements (e.g., silver and copper nanoparticles) has been widely recognized as exhibiting broad-spectrum bactericidal or bacteriostatic activity. So, in order to achieve a better therapeutic response, it is crucial to understand how these infections are different from others. This will allow us to find new biomaterials characterized by antifouling coatings with repellent properties or low adhesion towards microorganisms, or antimicrobial coatings that are capable of killing microbes approaching the surface, improving biomaterial functionalization strategies and supporting tissues’ bio-integration.
Beauty masks, diapers, wound dressings, wipes, protective clothes and biomedical products: all these high-value and/or large-volume products must be highly compatible with human skin and they should have specific functional properties, such as anti-microbial, anti-inflammatory and anti-oxidant properties. They are currently partially or totally produced using fossil-based sources, with evident issues linked to their end of life, as their waste generates an increasing environmental concern. On the contrary, biopolymers and active biomolecules from biobased sources could be used to produce new materials that are highly compatible with the skin and also biodegradable. The final products can be obtained by exploiting safe and smart nanotechnologies such as the extrusion of bionanocomposites and electrospinning/electrospray, as well as innovative surface modification and control methodologies. For all these reasons, recently, many researchers, such as those involved in the European POLYBIOSKIN project activities, have been working in the field of biomaterials with anti-microbial, anti-inflammatory and anti-oxidant properties, as well as biobased materials which are renewable and biodegradable. The present book gathered research and review papers dedicated to materials and technologies for high-performance products where the attention paid to health and environmental impact is efficiently integrated, considering both the skin-compatibility of the selected materials and their source/end of life.