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The Rare Isotope Accelerator (RIA) facility includes a driver linac for production of 400 kW CW heavy-ion beams. The initial acceleration of heavy-ions delivered from an ECR ion source can be effectively performed by a 57.5 MHz four-meter long RFQ. The principal specifications of the RFQ are: (1) formation of extremely low longitudinal emittance; (2) stable operation over a wide range of voltage for acceleration of various ion species needed for RIA operation; (3) simultaneous acceleration of two-charge states of uranium ions. CW operation of an accelerating structure leads to a number of requirements for the resonators such as high shunt impedance, efficient water cooling of all parts of the resonant cavity, mechanical stability together with precise alignment, reliable rf contacts, a stable operating mode and fine tuning of the resonant frequency during operation. To satisfy these requirements a new resonant structure has been developed. This paper discusses beam dynamics and electrodynamics design of the RFQ cavity, as well as, some aspects of the mechanical design of this low-frequency CW RFQ.
One of the greatest challenges for nuclear energy is how to properly manage the highly radioactive waste generated during irradiation in nuclear reactors. Accelerator Driven Systems (ADSs) may offer new prospects and advantages for the transmutation of such high level nuclear waste. ADS or accelerator driven transmutation of waste (ATW) consists of a high power proton accelerator, a heavy metal spallation target that produces neutrons when bombarded by the high power beam, and a sub-critical core that is neutronically coupled to the spallation target. This publication provides a comprehensive state of the art of the ADS technology by representing the different ADS concepts proposed worldwide in the last 15 years, as well as the related R&D activities and demonstration initiatives carried out at national international level.
This publication addresses recent developments in neutron generator (NG) technology. It presents information on compact instruments with high neutron yield to be used for neutron activation analysis (NAA) and prompt gamma neutron activation analysis in combination with high count rate spectrometers. Traditional NGs have been shown to be effective for applications including borehole logging, homeland security, nuclear medicine and the on-line analysis of aluminium, coal and cement. Pulsed fast thermal neutron analysis, as well as tagged and timed neutron analysis, are additional techniques which can be applied using NG. Furthermore, NG can effectively be used for elemental analysis and is also effective for analysis of hidden materials by neutron radiography. Useful guidelines for developing NG based research laboratories are also provided in this publication.
This third open access volume of the handbook series deals with accelerator physics, design, technology and operations, as well as with beam optics, dynamics and diagnostics. A joint CERN-Springer initiative, the "Particle Physics Reference Library" provides revised and updated contributions based on previously published material in the well-known Landolt-Boernstein series on particle physics, accelerators and detectors (volumes 21A,B1,B2,C), which took stock of the field approximately one decade ago. Central to this new initiative is publication under full open access.
Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.
Despite the often difficult and time-consuming effort of performing experiments with fast (14 MeV) neutrons, these neutrons can offer special insight into nucleus and other materials because of the absence of charge. 14 MeV Neutrons: Physics and Applications explores fast neutrons in basic science and applications to problems in medicine, the envir
This second open access volume of the handbook series deals with detectors, large experimental facilities and data handling, both for accelerator and non-accelerator based experiments. It also covers applications in medicine and life sciences. A joint CERN-Springer initiative, the "Particle Physics Reference Library" provides revised and updated contributions based on previously published material in the well-known Landolt-Boernstein series on particle physics, accelerators and detectors (volumes 21A, B1,B2,C), which took stock of the field approximately one decade ago. Central to this new initiative is publication under full open access
This volume presents the latest collection of immunophenotypic techniques and applications used in research and clinical settings. Chapters in this book cover topics such as constructions of high dimensions fluorescence and mass cytometry panels; fluorescence barcoding; using dried or lyophilized reagents; and immunophenotypic examples of specific cell types. The book concludes with a discussion on the critical roles of quality control and immunophenotyping in the clinical environment. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Immunophenotyping: Methods and Protocols is a valuable resource for any researchers, clinician, or scientist interested in learning more about this evolving field.
Fluid Bed Technology in Materials Processing comprehensively covers the various aspects of fluidization engineering and presents an elaborate examination of the applications in a multitude of materials processing techniques. This singular resource discusses: All the basic aspects of fluidization essential to understand and learn about various techniques The range of industrial applications Several examples in extraction and process metallurgy Fluidization in nuclear engineering and nuclear fuel cycle with numerous examples Innovative techniques and several advanced concepts of fluidization engineering, including use and applications in materials processing as well as environmental and bio-engineering Pros and cons of various fluidization equipment and specialty of their applications, including several examples Design aspects and modeling Topics related to distributors effects and flow regimes A separate chapter outlines the importance of fluidization engineering in high temperature processing, including an analysis of the fundamental concepts and applications of high temperature fluidized bed furnaces for several advanced materials processing techniques. Presenting information usually not available in a single source, Fluid Bed Technology in Materials Processing serves Fluidization engineers Practicing engineers in process metallurgy, mineral engineering, and chemical metallurgy Researchers in the field of chemical, metallurgical, nuclear, biological, environmental engineering Energy engineering professionals High temperature scientists and engineers Students and professionals who adopt modeling of fluidization in their venture for design and scale up