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Myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS) are serious, debilitating conditions that affect millions of people in the United States and around the world. ME/CFS can cause significant impairment and disability. Despite substantial efforts by researchers to better understand ME/CFS, there is no known cause or effective treatment. Diagnosing the disease remains a challenge, and patients often struggle with their illness for years before an identification is made. Some health care providers have been skeptical about the serious physiological - rather than psychological - nature of the illness. Once diagnosed, patients often complain of receiving hostility from their health care provider as well as being subjected to treatment strategies that exacerbate their symptoms. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome proposes new diagnostic clinical criteria for ME/CFS and a new term for the illness - systemic exertion intolerance disease(SEID). According to this report, the term myalgic encephalomyelitis does not accurately describe this illness, and the term chronic fatigue syndrome can result in trivialization and stigmatization for patients afflicted with this illness. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome stresses that SEID is a medical - not a psychiatric or psychological - illness. This report lists the major symptoms of SEID and recommends a diagnostic process.One of the report's most important conclusions is that a thorough history, physical examination, and targeted work-up are necessary and often sufficient for diagnosis. The new criteria will allow a large percentage of undiagnosed patients to receive an accurate diagnosis and appropriate care. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome will be a valuable resource to promote the prompt diagnosis of patients with this complex, multisystem, and often devastating disorder; enhance public understanding; and provide a firm foundation for future improvements in diagnosis and treatment.
Originally published in 1993, this monograph addresses a central problem in Piaget’s work, which is the temporal construction of necessary knowledge. The main argument is that both normative and empirical issues are relevant to a minimally adequate account of the development of modal understanding. This central argument embodies three main claims. One claim is philosophical. Although the concepts of knowledge and necessity are problematic, there is sufficient agreement about their core elements due to the fundamental difference between truth-value and modality. Any account of human rationality has to respect this distinction. The second claim is that this normative distinction is not always respected in psychological research on the origins of knowledge where emphasis is placed on the procedures and methods used to gain good empirical evidence. An account of the initial acquisition of knowledge is not thereby an account of its legitimation in the human mind. The third claim relates to epistemology. Intellectual development is a process in which available knowledge is used in the construction of better knowledge. The monograph identifies features of a modal model of intellectual construction, whereby some form of necessary knowledge is always used. Intellectual development occurs as the reduction of modal errors through the differentiation and coordination of available forms of modal understanding. Piaget’s work continues to provide distinctive and intelligible answers to a substantive and outstanding problem.
In response to a request by the Health Care Financing Administration (HCFA), the Institute of Medicine proposed a study to examine definitions of serious or complex medical conditions and related issues. A seven-member committee was appointed to address these issues. Throughout the course of this study, the committee has been aware of the fact that the topic addressed by this report concerns one of the most critical issues confronting HCFA, health care plans and providers, and patients today. The Medicare+Choice regulations focus on the most vulnerable populations in need of medical care and other services-those with serious or complex medical conditions. Caring for these highly vulnerable populations poses a number of challenges. The committee believes, however, that the current state of clinical and research literature does not adequately address all of the challenges and issues relevant to the identification and care of these patients.
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
This is a comprehensive, state-of-the-art guide to the diagnosis, treatment, and biology of multiple myeloma and related plasma disorders. Edited and written by a multidisciplinary group of recognized authorities from the Mayo Clinic, it presents clear guidelines on diagnosis and therapy and covers all aspects of multiple myeloma, from molecular classification and diagnosis, to risk stratification and therapy. Closely related plasma cell disorders such as solitary plasmacytoma, Waldenstrom macroglobulinemia, and light chain amyloidosis are discussed in detail as well. The book addresses often overlooked topics, including the role of radiation therapy, vertebral augmentation, and supportive care. Our understanding of this group of disorders is developing at an unprecedented rate, and Multiple Myeloma meets the need among oncologists and hematologists for a clear, timely, and authoritative resource on their biology, diagnosis, and treatment.
Food safety regulators face a daunting task: crafting food safety performance standards and systems that continue in the tradition of using the best available science to protect the health of the American public, while working within an increasingly antiquated and fragmented regulatory framework. Current food safety standards have been set over a period of years and under diverse circumstances, based on a host of scientific, legal, and practical constraints. Scientific Criteria to Ensure Safe Food lays the groundwork for creating new regulations that are consistent, reliable, and ensure the best protection for the health of American consumers. This book addresses the biggest concerns in food safetyâ€"including microbial disease surveillance plans, tools for establishing food safety criteria, and issues specific to meat, dairy, poultry, seafood, and produce. It provides a candid analysis of the problems with the current system, and outlines the major components of the task at hand: creating workable, streamlined food safety standards and practices.
Critical Readings on Piaget is a follow-up to Piaget: Critical Assessments a collection of eighty-three papers dealing with the critique of Piaget's work in psychology, education and philosophy during the period 1950-90. This new collection tracks developments in the most recent published work during the period 1990-95, with an integral guide and editorial commentary by Leslie Smith. Starting with Piaget's epistemology, a major intellectual resource in departmental psychology and eduction, Leslie Smith sets out the main elements of Piaget's position in relation to twenty one papers, dealing with equilibration and equilibrium, education and social development, reasoning development, number development and modal knowledge. A conclusion examines the psychological and educational assessment of Piaget's epistemology. This collection of distinctive studies during the last five years provides high-profile and engaging examples from current research in this area. It will provide a useful and compact text for undergraduate and postgraduate students and researchers.
Wittgenstein: Meaning and Mind is the third volume of a four-volume analytical commentary on Wittgenstein's Philosophical Investigations, consisting of two parts. Part 1 is a sequence of fifteen essays that examine in detail all the major topics discussed in Philosophical Investigations §§243-427. These include the private language arguments, privacy, private ostensive definition, the nature of the mind, the inner and the outer, behaviour and behaviourism, thought, imagination, the self, consciousness, and criteria. Published in 1990 to widespread acclaim as a scholarly tour de force, the first edition of this volume of essays provides a comprehensive survey of these themes, the history of their treatment in early modern and modern philosophy, the development of Wittgenstein's ideas on these subjects from 1929 onwards, and an elaborate analysis of his definitive arguments in the Investigations. The new second edition has been thoroughly revised by the author and features four new essays. These include a survey of the evolution of the private language arguments in Wittgenstein's oeuvre and their role within the developing argument of the Investigations, a comprehensive essay on private ownership of experience and its pitfalls, a detailed examination and defence of Wittgenstein's repudiation of subjective knowledge of one's experience, and an overview of the achievement and importance of the private language arguments. Revised essays examine new objections to Wittgenstein's arguments – which are found wanting– and incorporate new materials from the Nachlass that were not known to exist in 1990. All references have been adjusted to the revised fourth edition of the Investigations, but previous pagination in the first and second editions has been retained in parentheses. These revisions bring the book up to the high standard of the extensively revised editions of Wittgenstein: Understanding and Meaning (Blackwell, 2005) and Wittgenstein: Rules, Grammar and Necessity (Wiley Blackwell, 2009). They ensure that this survey of Wittgenstein's private language arguments and of his accounts of thought, imagination, consciousness, the self, and criteria will remain the essential reference work on the Investigations for the foreseeable future.
Presenting a commentary on the philosophy of Ludwig Wittgenstein, this book offers guidance to reading Wittgenstein and a methodology for interpreting his works. It covers the entirety of Wittgenstein's career, examining the relationship between the early, middle and later periods of his philosophy.