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DEEP LEARNING FOR TREATMENTS The book provides the direction for future research in deep learning in terms of its role in targeted treatment, biological systems, site-specific drug delivery, risk assessment in therapy, etc. Deep Learning for Targeted Treatments describes the importance of the deep learning framework for patient care, disease imaging/detection, and health management. Since deep learning can and does play a major role in a patient’s healthcare management by controlling drug delivery to targeted tissues or organs, the main focus of the book is to leverage the various prospects of the DL framework for targeted therapy of various diseases. In terms of its industrial significance, this general-purpose automatic learning procedure is being widely implemented in pharmaceutical healthcare. Audience The book will be immensely interesting and useful to researchers and those working in the areas of clinical research, disease management, pharmaceuticals, R&D formulation, deep learning analytics, remote healthcare management, healthcare analytics, and deep learning in the healthcare industry.
Multimodal Scene Understanding: Algorithms, Applications and Deep Learning presents recent advances in multi-modal computing, with a focus on computer vision and photogrammetry. It provides the latest algorithms and applications that involve combining multiple sources of information and describes the role and approaches of multi-sensory data and multi-modal deep learning. The book is ideal for researchers from the fields of computer vision, remote sensing, robotics, and photogrammetry, thus helping foster interdisciplinary interaction and collaboration between these realms. Researchers collecting and analyzing multi-sensory data collections – for example, KITTI benchmark (stereo+laser) - from different platforms, such as autonomous vehicles, surveillance cameras, UAVs, planes and satellites will find this book to be very useful. - Contains state-of-the-art developments on multi-modal computing - Shines a focus on algorithms and applications - Presents novel deep learning topics on multi-sensor fusion and multi-modal deep learning
​This book provides a complete overview of the role of machine learning in radiation oncology and medical physics, covering basic theory, methods, and a variety of applications in medical physics and radiotherapy. An introductory section explains machine learning, reviews supervised and unsupervised learning methods, discusses performance evaluation, and summarizes potential applications in radiation oncology. Detailed individual sections are then devoted to the use of machine learning in quality assurance; computer-aided detection, including treatment planning and contouring; image-guided radiotherapy; respiratory motion management; and treatment response modeling and outcome prediction. The book will be invaluable for students and residents in medical physics and radiation oncology and will also appeal to more experienced practitioners and researchers and members of applied machine learning communities.
This book provides a structured treatment of the key principles and techniques for enabling efficient processing of deep neural networks (DNNs). DNNs are currently widely used for many artificial intelligence (AI) applications, including computer vision, speech recognition, and robotics. While DNNs deliver state-of-the-art accuracy on many AI tasks, it comes at the cost of high computational complexity. Therefore, techniques that enable efficient processing of deep neural networks to improve key metrics—such as energy-efficiency, throughput, and latency—without sacrificing accuracy or increasing hardware costs are critical to enabling the wide deployment of DNNs in AI systems. The book includes background on DNN processing; a description and taxonomy of hardware architectural approaches for designing DNN accelerators; key metrics for evaluating and comparing different designs; features of DNN processing that are amenable to hardware/algorithm co-design to improve energy efficiency and throughput; and opportunities for applying new technologies. Readers will find a structured introduction to the field as well as formalization and organization of key concepts from contemporary work that provide insights that may spark new ideas.
Precision Medicine and Artificial Intelligence: The Perfect Fit for Autoimmunity covers background on artificial intelligence (AI), its link to precision medicine (PM), and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as AI has gained significant attention during the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems have enabled the generation of large datasets, making autoimmunity an ideal target for AI and precision medicine. More and more diagnostic products utilize AI, which is also starting to be supported by regulatory agencies such as the Food and Drug Administration (FDA). Knowledge generation by leveraging large datasets including demographic, environmental, clinical and biomarker data has the potential to not only impact the diagnosis of patients, but also disease prediction, prognosis and treatment options. - Allows the readers to gain an overview on precision medicine for autoimmune diseases leveraging AI solutions - Provides background, milestone and examples of precision medicine - Outlines the paradigm shift towards precision medicine driven by value-based systems - Discusses future applications of precision medicine research using AI - Other aspects covered in the book include regulatory insights, data analytics and visualization, types of biomarkers as well as the role of the patient in precision medicine
The statistics profession is at a unique point in history. The need for valid statistical tools is greater than ever; data sets are massive, often measuring hundreds of thousands of measurements for a single subject. The field is ready to move towards clear objective benchmarks under which tools can be evaluated. Targeted learning allows (1) the full generalization and utilization of cross-validation as an estimator selection tool so that the subjective choices made by humans are now made by the machine, and (2) targeting the fitting of the probability distribution of the data toward the target parameter representing the scientific question of interest. This book is aimed at both statisticians and applied researchers interested in causal inference and general effect estimation for observational and experimental data. Part I is an accessible introduction to super learning and the targeted maximum likelihood estimator, including related concepts necessary to understand and apply these methods. Parts II-IX handle complex data structures and topics applied researchers will immediately recognize from their own research, including time-to-event outcomes, direct and indirect effects, positivity violations, case-control studies, censored data, longitudinal data, and genomic studies.
Deep Learning (DL) is a method of machine learning, running over Artificial Neural Networks, that uses multiple layers to extract high-level features from large amounts of raw data. Deep Learning methods apply levels of learning to transform input data into more abstract and composite information. Handbook for Deep Learning in Biomedical Engineering: Techniques and Applications gives readers a complete overview of the essential concepts of Deep Learning and its applications in the field of Biomedical Engineering. Deep learning has been rapidly developed in recent years, in terms of both methodological constructs and practical applications. Deep Learning provides computational models of multiple processing layers to learn and represent data with higher levels of abstraction. It is able to implicitly capture intricate structures of large-scale data and is ideally suited to many of the hardware architectures that are currently available. The ever-expanding amount of data that can be gathered through biomedical and clinical information sensing devices necessitates the development of machine learning and AI techniques such as Deep Learning and Convolutional Neural Networks to process and evaluate the data. Some examples of biomedical and clinical sensing devices that use Deep Learning include: Computed Tomography (CT), Magnetic Resonance Imaging (MRI), Ultrasound, Single Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET), Magnetic Particle Imaging, EE/MEG, Optical Microscopy and Tomography, Photoacoustic Tomography, Electron Tomography, and Atomic Force Microscopy. Handbook for Deep Learning in Biomedical Engineering: Techniques and Applications provides the most complete coverage of Deep Learning applications in biomedical engineering available, including detailed real-world applications in areas such as computational neuroscience, neuroimaging, data fusion, medical image processing, neurological disorder diagnosis for diseases such as Alzheimer's, ADHD, and ASD, tumor prediction, as well as translational multimodal imaging analysis. - Presents a comprehensive handbook of the biomedical engineering applications of DL, including computational neuroscience, neuroimaging, time series data such as MRI, functional MRI, CT, EEG, MEG, and data fusion of biomedical imaging data from disparate sources, such as X-Ray/CT - Helps readers understand key concepts in DL applications for biomedical engineering and health care, including manifold learning, classification, clustering, and regression in neuroimaging data analysis - Provides readers with key DL development techniques such as creation of algorithms and application of DL through artificial neural networks and convolutional neural networks - Includes coverage of key application areas of DL such as early diagnosis of specific diseases such as Alzheimer's, ADHD, and ASD, and tumor prediction through MRI and translational multimodality imaging and biomedical applications such as detection, diagnostic analysis, quantitative measurements, and image guidance of ultrasonography
Biology, medicine and biochemistry have become data-centric fields for which Deep Learning methods are delivering groundbreaking results. Addressing high impact challenges, Deep Learning in Biology and Medicine provides an accessible and organic collection of Deep Learning essays on bioinformatics and medicine. It caters for a wide readership, ranging from machine learning practitioners and data scientists seeking methodological knowledge to address biomedical applications, to life science specialists in search of a gentle reference for advanced data analytics.With contributions from internationally renowned experts, the book covers foundational methodologies in a wide spectrum of life sciences applications, including electronic health record processing, diagnostic imaging, text processing, as well as omics-data processing. This survey of consolidated problems is complemented by a selection of advanced applications, including cheminformatics and biomedical interaction network analysis. A modern and mindful approach to the use of data-driven methodologies in the life sciences also requires careful consideration of the associated societal, ethical, legal and transparency challenges, which are covered in the concluding chapters of this book.
Following significant advances in deep learning and related areas interest in artificial intelligence (AI) has rapidly grown. In particular, the application of AI in drug discovery provides an opportunity to tackle challenges that previously have been difficult to solve, such as predicting properties, designing molecules and optimising synthetic routes. Artificial Intelligence in Drug Discovery aims to introduce the reader to AI and machine learning tools and techniques, and to outline specific challenges including designing new molecular structures, synthesis planning and simulation. Providing a wealth of information from leading experts in the field this book is ideal for students, postgraduates and established researchers in both industry and academia.
This textbook for graduate students in statistics, data science, and public health deals with the practical challenges that come with big, complex, and dynamic data. It presents a scientific roadmap to translate real-world data science applications into formal statistical estimation problems by using the general template of targeted maximum likelihood estimators. These targeted machine learning algorithms estimate quantities of interest while still providing valid inference. Targeted learning methods within data science area critical component for solving scientific problems in the modern age. The techniques can answer complex questions including optimal rules for assigning treatment based on longitudinal data with time-dependent confounding, as well as other estimands in dependent data structures, such as networks. Included in Targeted Learning in Data Science are demonstrations with soft ware packages and real data sets that present a case that targeted learning is crucial for the next generation of statisticians and data scientists. Th is book is a sequel to the first textbook on machine learning for causal inference, Targeted Learning, published in 2011. Mark van der Laan, PhD, is Jiann-Ping Hsu/Karl E. Peace Professor of Biostatistics and Statistics at UC Berkeley. His research interests include statistical methods in genomics, survival analysis, censored data, machine learning, semiparametric models, causal inference, and targeted learning. Dr. van der Laan received the 2004 Mortimer Spiegelman Award, the 2005 Van Dantzig Award, the 2005 COPSS Snedecor Award, the 2005 COPSS Presidential Award, and has graduated over 40 PhD students in biostatistics and statistics. Sherri Rose, PhD, is Associate Professor of Health Care Policy (Biostatistics) at Harvard Medical School. Her work is centered on developing and integrating innovative statistical approaches to advance human health. Dr. Rose’s methodological research focuses on nonparametric machine learning for causal inference and prediction. She co-leads the Health Policy Data Science Lab and currently serves as an associate editor for the Journal of the American Statistical Association and Biostatistics.