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A comparison of the genetic circuits of Homo sapiens and Drosophila reveals the evidence for deep homology.
Humans and flies look nothing alike, yet their genetic circuits are remarkably similar. Here, Lewis I. Held, Jr compares the genetics and development of the two to review the evidence for deep homology, the biggest discovery from the emerging field of evolutionary developmental biology. Remnants of the operating system of our hypothetical common ancestor 600 million years ago are compared in chapters arranged by region of the body, from the nervous system, limbs and heart, to vision, hearing and smell. Concept maps provide a clear understanding of the complex subjects addressed, while encyclopaedic tables offer comprehensive inventories of genetic information. Written in an engaging style with a reference section listing thousands of relevant publications, this is a vital resource for scientific researchers, and graduate and undergraduate students.
Homology, the similarity between organisms that is due to common ancestry, is the central concept of all comparative biology. However, the application of this concept varies depending on the data being examined. This volume represents a state-of-the-art treatment of the different applications of this unifying concept. Chapters deal with homology on all levels, from molecules to behavior, and are authored by leading contributors to systematics, natural history, and evolutionary, developmental, and comparative biology. Commemoration of the 150th anniverary of Sir Richard Owen's seminal paper distinguishing homology from analogy Contributors who are renowned leaders in compative biology Coverage that is both comprehensive and interdisciplinary
This textbook provides a gentle introduction to intersection homology and perverse sheaves, where concrete examples and geometric applications motivate concepts throughout. By giving a taste of the main ideas in the field, the author welcomes new readers to this exciting area at the crossroads of topology, algebraic geometry, analysis, and differential equations. Those looking to delve further into the abstract theory will find ample references to facilitate navigation of both classic and recent literature. Beginning with an introduction to intersection homology from a geometric and topological viewpoint, the text goes on to develop the sheaf-theoretical perspective. Then algebraic geometry comes to the fore: a brief discussion of constructibility opens onto an in-depth exploration of perverse sheaves. Highlights from the following chapters include a detailed account of the proof of the Beilinson–Bernstein–Deligne–Gabber (BBDG) decomposition theorem, applications of perverse sheaves to hypersurface singularities, and a discussion of Hodge-theoretic aspects of intersection homology via Saito’s deep theory of mixed Hodge modules. An epilogue offers a succinct summary of the literature surrounding some recent applications. Intersection Homology & Perverse Sheaves is suitable for graduate students with a basic background in topology and algebraic geometry. By building context and familiarity with examples, the text offers an ideal starting point for those entering the field. This classroom-tested approach opens the door to further study and to current research.
Knot theory is a classical area of low-dimensional topology, directly connected with the theory of three-manifolds and smooth four-manifold topology. In recent years, the subject has undergone transformative changes thanks to its connections with a number of other mathematical disciplines, including gauge theory; representation theory and categorification; contact geometry; and the theory of pseudo-holomorphic curves. Starting from the combinatorial point of view on knots using their grid diagrams, this book serves as an introduction to knot theory, specifically as it relates to some of the above developments. After a brief overview of the background material in the subject, the book gives a self-contained treatment of knot Floer homology from the point of view of grid diagrams. Applications include computations of the unknotting number and slice genus of torus knots (asked first in the 1960s and settled in the 1990s), and tools to study variants of knot theory in the presence of a contact structure. Additional topics are presented to prepare readers for further study in holomorphic methods in low-dimensional topology, especially Heegaard Floer homology. The book could serve as a textbook for an advanced undergraduate or part of a graduate course in knot theory. Standard background material is sketched in the text and the appendices.
This book analyses the nature-nurture controversy and recent history and methodology of behavioral and psychiatric genetics. It discusses genetic reductionism, determinism, heritability, "free will," and quantitative and molecular genetics. New genome-wide association studies (GWAS) that produced a "paradigm shift" in the subject are reviewed, as are genetics of personality and schizophrenia.
This book, by leading scholars, represents some of the main work in progress in biolinguistics. It offers fresh perspectives on language evolution and variation, new developments in theoretical linguistics, and insights on the relations between variation in language and variation in biology. The authors address the Darwinian questions on the origin and evolution of language from a minimalist perspective, and provide elegant solutions to the evolutionary gap between human language and communication in all other organisms. They consider language variation in the context of current biological approaches to species diversity - the 'evo-devo revolution' - which bring to light deep homologies between organisms. In dispensing with the classical notion of syntactic parameters, the authors argue that language variation, like biodiversity, is the result of experience and thus not a part of the language faculty in the narrow sense. They also examine the nature of this core language faculty, the primary categories with which it is concerned, the operations it performs, the syntactic constraints it poses on semantic interpretation and the role of phases in bridging the gap between brain and syntax. Written in language accessible to a wide audience, The Biolinguistic Enterprise will appeal to scholars and students of linguistics, cognitive science, biology, and natural language processing.
Since the 1980s, a renewed understanding of molecular development has afforded an unprecedented level of knowledge of the mechanisms by which phenotype in animals and plants has evolved. In this volume, top scientists in these fields provide perspectives on how molecular data in biology help to elucidate key questions in estimating paleontological divergence and in understanding the mechanisms behind phenotypic evolution. Paleobiological questions such as genome size, digit homologies, genetic control cascades behind phenotype, estimates of vertebrate divergence dates, and rates of morphological evolution are addressed, with a special emphasis on how molecular biology can inform paleontology, directly and indirectly, to better understand life's past. Highlighting a significant shift towards interdisciplinary collaboration, this is a valuable resource for students and researchers interested in the integration of organismal and molecular biology.
A multi-disciplinary look at the current state of knowledge regarding motor control and movement—from molecular biology to robotics The last two decades have seen a dramatic increase in the number of sophisticated tools and methodologies for exploring motor control and movement. Multi-unit recordings, molecular neurogenetics, computer simulation, and new scientific approaches for studying how muscles and body anatomy transform motor neuron activity into movement have helped revolutionize the field. Neurobiology of Motor Control brings together contributions from an interdisciplinary group of experts to provide a review of the current state of knowledge about the initiation and execution of movement, as well as the latest methods and tools for investigating them. The book ranges from the findings of basic scientists studying model organisms such as mollusks and Drosophila, to biomedical researchers investigating vertebrate motor production to neuroengineers working to develop robotic and smart prostheses technologies. Following foundational chapters on current molecular biological techniques, neuronal ensemble recording, and computer simulation, it explores a broad range of related topics, including the evolution of motor systems, directed targeted movements, plasticity and learning, and robotics. Explores motor control and movement in a wide variety of organisms, from simple invertebrates to human beings Offers concise summaries of motor control systems across a variety of animals and movement types Explores an array of tools and methodologies, including electrophysiological techniques, neurogenic and molecular techniques, large ensemble recordings, and computational methods Considers unresolved questions and how current scientific advances may be used to solve them going forward Written specifically to encourage interdisciplinary understanding and collaboration, and offering the most wide-ranging, timely, and comprehensive look at the science of motor control and movement currently available, Neurobiology of Motor Control is a must-read for all who study movement production and the neurobiological basis of movement—from molecular biologists to roboticists.
How language evolved has been called "the hardest problem in science." In Adam's Tongue, Derek Bickerton—long a leading authority in this field—shows how and why previous attempts to solve that problem have fallen short. Taking cues from topics as diverse as the foraging strategies of ants, the distribution of large prehistoric herbivores, and the construction of ecological niches, Bickerton produces a dazzling new alternative to the conventional wisdom. Language is unique to humans, but it isn't the only thing that sets us apart from other species—our cognitive powers are qualitatively different. So could there be two separate discontinuities between humans and the rest of nature? No, says Bickerton; he shows how the mere possession of symbolic units—words—automatically opened a new and different cognitive universe, one that yielded novel innovations ranging from barbed arrowheads to the Apollo spacecraft. Written in Bickerton's lucid and irreverent style, this book is the first that thoroughly integrates the story of how language evolved with the story of how humans evolved. Sure to be controversial, it will make indispensable reading both for experts in the field and for every reader who has ever wondered how a species as remarkable as ours could have come into existence.