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Arthur Koestler's extraordinary history of humanity's changing vision of the universe In this masterly synthesis, Arthur Koestler cuts through the sterile distinction between 'sciences' and 'humanities' to bring to life the whole history of cosmology from the Babylonians to Newton. He shows how the tragic split between science and religion arose and how, in particular, the modern world-view replaced the medieval world-view in the scientific revolution of the seventeenth century. He also provides vivid and judicious pen-portraits of a string of great scientists and makes clear the role that political bias and unconscious prejudice played in their creativity.
Organ transplantation has revolutionized the treatment for end-stage organ failure. Immunosuppression is still a major approach currently used in the prevention and treatment of allograft rejection. Both editors Dr. Chen and Dr. Qian have been contributing to preclinical evaluation of immunosuppressants for more than 25 years in North America. Experts from the United States, Canada, the United Kingdom, China, Japan, Germany, Sweden, Hungary and Brazil contributed 23 chapters to this book, providing details of immunological basis in transplantation. They also describe six classes of immunosuppressive agents (calcineurin inhibitors, mTOR inhibitors, JAK-STAT inhibitors, antiproliferative agents, costimulation blockers and corticosteroids), as well as ischemia/reperfusion injury treated agents. Additionally, the new development of cell therapy in the induction of transplant tolerance is introduced. This book provides many important references for the research direction of novel immunosuppressants. Readers that will find this book useful include transplant physicians, surgeons, nurses, immunologists, pharmacologists, pharmacists, medical students, residents and trainees in transplantation.
Since the first edition of this book was published in 2001, MapleTM has evolved from Maple V into Maple 13. Accordingly, this new edition has been thoroughly updated and expanded to include more applications, examples, and exercises, all with solutions; two new chapters on neural networks and simulation have also been added. The author has emphasized breadth of coverage rather than fine detail, and theorems with proof are kept to a minimum. This text is aimed at senior undergraduates, graduate students, and working scientists in various branches of applied mathematics, the natural sciences, and engineering.
The MRS Symposium Proceeding series is an internationally recognised reference suitable for researchers and practitioners.
The serious illness of three presidents—Woodrow Wilson, Franklin Delano Roosevelt, and John F. Kennedy—as well as the injury Ronald Reagan received in the assassination attempt upon him have revealed our woefully inadequate system for handling presidential incapacity. The authors believe that this flawed system poses a major threat to the nation, and they provide sobering reports on how the government functioned (or failed to function) during times of presidential impairment. The public was kept in the dark regarding the gravity of the presidential condition, often unaware that critical decisions were being made while the president was suffering from a severe illness. Hidden Illness in the White House contains startling new information on the severity of Roosevelt’s illness during the crucial Yalta negotiations and the fact that Kennedy suffered from Addison’s disease, a life-threatening illness, long before he was elected to the presidency. In each case the authors demonstrate that a largely successful effort was made to conceal the president’s true medical condition from the public.
In the last two decades modal logic has undergone an explosive growth, to thepointthatacompletebibliographyofthisbranchoflogic,supposingthat someone were capable to compile it, would ?ll itself a ponderous volume. What is impressive in the growth of modal logic has not been so much the quick accumulation of results but the richness of its thematic dev- opments. In the 1960s, when Kripke semantics gave new credibility to the logic of modalities? which was already known and appreciated in the Ancient and Medieval times? no one could have foreseen that in a short time modal logic would become a lively source of ideas and methods for analytical philosophers,historians of philosophy,linguists, epistemologists and computer scientists. The aim which oriented the composition of this book was not to write a new manual of modal logic (there are a lot of excellent textbooks on the market, and the expert reader will realize how much we bene?ted from manyofthem)buttoo?ertoeveryreader,evenwithnospeci?cbackground in logic, a conceptually linear path in the labyrinth of the current panorama of modal logic. The notion which in our opinion looked suitable to work as a compass in this enterprise was the notion of multimodality, or, more speci?cally, the basic idea of grounding systems on languages admitting more than one primitive modal operator.
From an internationally respected team of clinical and research experts comes this groundbreaking book that synthesizes the body of nursing research for 192 common medical-surgical interventions. Ideal for both nursing students and practicing nurses, this collection of research-based guidelines helps you evaluate and apply the latest evidence to clinical practice.