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This reference work, the result of a conference co-chaired with Nobel laureate Werner Arber, addresses the molecular strategies by which lineages of organisms respond to challenges and opportunities in their environment. It explores the notion that organisms have evolved the ability to modulate the rate, location and extent of genetic variation. Jumps in efficiency, made possible by development of novel efficient evolutionary strategies, could fuel rapid, saltatory expansion of species into novel niches as each innovation evolves. An up-to-date assessment is provided on biochemical mechanisms available to modulate the rate of genetic change at specific sites within a genome, the induction in certain environments of enzymes with altered sequence-dependent recombination, mismatch repair and/or replication fidelity, and statistical evidence for nonrandom genetic events. This discussion of genomic strategies for evolution has profound implications for basic biology and evolutionary theory. The subjects explored are important ones in understanding inherited diseases, tumor progression and the challenges posed by pathogenic organisms.
With the publication in 1859 of On the Origin of Species by Means of Natural Selection, Charles Darwin established evolution by common descent as the dominant scientific explanation for nature's diversity. This was to be his gift to science and society; at last, we had an explanation for how life came to be on Earth. Scientists agree that the evolutionary origin of animals and plants is a scientific conclusion beyond reasonable doubt. They place it beside such established concepts as the roundness of the earth, its revolution around the sun, and the molecular composition of matter. That evolution has occurred, in other words, is a fact. Yet as we approach the bicentennial celebration of Darwin's birth, the world finds itself divided over the truth of evolutionary theory. Consistently endorsed as "good science" by experts and overwhelmingly accepted as fact by the scientific community, it is not always accepted by the public, and our schools continue to be battlegrounds for this conflict. From the Tennessee trial of a biology teacher who dared to teach Darwin's theory to his students in 1925 to Tammy Kitzmiller's 2005 battle to keep intelligent design out of the Dover district schools in Pennsylvania, it's clear that we need to cut through the propaganda to quell the cacophony of raging debate. With the publication of Darwin's Gift, a voice at once fresh and familiar brings a rational, measured perspective to the science of evolution. An acclaimed evolutionary biologist with a background in theology, Francisco Ayala offers clear explanations of the science, reviews the history that led us to ratify Darwin's theories, and ultimately provides a clear path for a confused and conflicted public.
This book proposes an important new paradigm for understanding biological evolution. Shapiro demonstrates why traditional views of evolution are inadequate to explain the latest evidence, and presents an alternative. His information- and systems-based approach integrates advances in symbiogenesis, epigenetics, and saltationism, and points toward an emerging synthesis of physical, information, and biological sciences.
Do our genes determine our behavior? Do humans occupy a unique position in evolution? To clarify these provoking questions, the author takes the reader on an ambitious and entertaining journey through a variety of scientific disciplines. In doing so, he creates an image of human evolution that argues that our entire individual knowledge is determined - to the smallest detail - by phylogeny. A provoking and controversial analysis of the theory of our inability to learn something new and of the extent to which our behavior is determined by our genes.
When Michael J. Behe's first book, Darwin's Black Box, was published in 1996, it launched the intelligent design movement. Critics howled, yet hundreds of thousands of readers -- and a growing number of scientists -- were intrigued by Behe's claim that Darwinism could not explain the complex machinery of the cell. Now, in his long-awaited follow-up, Behe presents far more than a challenge to Darwinism: He presents the evidence of the genetics revolution -- the first direct evidence of nature's mutational pathways -- to radically redefine the debate about Darwinism. How much of life does Darwin's theory explain? Most scientists believe it accounts for everything from the machinery of the cell to the history of life on earth. Darwin's ideas have been applied to law, culture, and politics. But Darwin's theory has been proven only in one sense: There is little question that all species on earth descended from a common ancestor. Overwhelming anatomical, genetic, and fossil evidence exists for that claim. But the crucial question remains: How did it happen? Darwin's proposed mechanism -- random mutation and natural selection -- has been accepted largely as a matter of faith and deduction or, at best, circumstantial evidence. Only now, thanks to genetics, does science allow us to seek direct evidence. The genomes of many organisms have been sequenced, and the machinery of the cell has been analyzed in great detail. The evolutionary responses of microorganisms to antibiotics and humans to parasitic infections have been traced over tens of thousands of generations. As a result, for the first time in history Darwin's theory can be rigorously evaluated. The results are shocking. Although it can explain marginal changes in evolutionary history, random mutation and natural selection explain very little of the basic machinery of life. The "edge" of evolution, a line that defines the border between random and nonrandom mutation, lies very far from where Darwin pointed. Behe argues convincingly that most of the mutations that have defined the history of life on earth have been nonrandom. Although it will be controversial and stunning, this finding actually fits a general pattern discovered by other branches of science in recent decades: The universe as a whole was fine-tuned for life. From physics to cosmology to chemistry to biology, life on earth stands revealed as depending upon an endless series of unlikely events. The clear conclusion: The universe was designed for life.
This book formulates a relativistic theory of biology, challenging the common gene-centred view of organisms.
If Darwin were to examine the evidence today using modern science, would his conclusions be the same? Charles Darwin’s On the Origin of Species, published over 150 years ago, is considered one of history’s most influential books and continues to serve as the foundation of thought for evolutionary biology. Since Darwin’s time, however, new fields of science have immerged that simply give us better answers to the question of origins. With a Ph.D. in cell and developmental biology from Harvard University, Dr. Nathaniel Jeanson is uniquely qualified to investigate what genetics reveal about origins. The Origins Puzzle Comes Together If the science surrounding origins were a puzzle, Darwin would have had fewer than 15% of the pieces to work with when he developed his theory of evolution. We now have a much greater percentage of the pieces because of modern scientific research. As Dr. Jeanson puts the new pieces together, a whole new picture emerges, giving us a testable, predictive model to explain the origin of species. A New Scientific Revolution Begins Darwin’s theory of evolution may be one of science’s “sacred cows,” but genetics research is proving it wrong. Changing an entrenched narrative, even if it’s wrong, is no easy task. Replacing Darwin asks you to consider the possibility that, based on genetics research, our origins are more easily understood in the context of . . . In the beginning . . . God, with the timeline found in the biblical narrative of Genesis. There is a better answer to the origins debate than what we have been led to believe. Let the revolution begin!
The theory of evolution by natural selection did not spring fully formed and unprecedented from the brain of Charles Darwin. The idea of evolution had been around, in various guises, since the time of Ancient Greece. And nor did theorizing about evolution stop with what Daniel Dennett called "Darwin’s dangerous idea." In this riveting new book, bestselling science writers John and Mary Gribbin explore the history of the idea of evolution, showing how Darwin's theory built on what went before and how it was developed in the twentieth century, through an understanding of genetics and the biochemical basis of evolution, into the so-called "modern synthesis" and beyond. Darwin deserves his recognition as the primary proponent of the idea of natural selection, but as the authors show, his contribution was one link in a chain that extends back into antiquity and is still being forged today.