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For over a thousand years, they have stared through the invisible force separating their world from ours, and grew hungry. Now, they've found a way through. Darkness from their side swallows our skies, their diseases eat through our human bodies, leaving behind soulless husks … and worse. Only two things can save us: a mysterious power locked in a small chest covered with undecipherable glyphs, and the seven year old girl it chose as its protector. A young Katie, trying to make sense of the grainy flashes from her past, escapes an organization determined to use her untapped special abilities to open a mysterious box she knows nothing about. With the Artifact in tow, she is hunted until rescued by a haunted, PTSD Vietnam vet Jonas Montgomery. Surviving the Viet Cong and many battles with the unwelcome visitors, Jonas finds his inner demons even more difficult. His only purpose in life—protect and train the girl to master what lies within her. The dark forces plaguing our world increase. Jonas and Katie must take a stand, or the final chance to save Earth vanishes.
Unparalleled access to the entire central nervous system with over four hundred gross neuropathology images from adult and paediatric post-mortem tissues.
“Takes readers on illuminating scientific adventure, beginning sixty-six million years ago, that connects dinosaurs, comets, DNA, and the future of the planet.” —Huffington Post In this brilliant exploration of our cosmic environment, the renowned particle physicist and New York Times–bestselling author of Warped Passages and Knocking on Heaven’s Door uses her research into dark matter to illuminate the startling connections between the furthest reaches of space and life here on Earth. Sixty-six million years ago, an object the size of a city descended from space to crash into Earth, creating a devastating cataclysm that killed off the dinosaurs, along with three-quarters of the other species on the planet. What was its origin? In Dark Matter and the Dinosaurs, Lisa Randall proposes it was a comet that was dislodged from its orbit as the Solar System passed through a disk of dark matter embedded in the Milky Way. In a sense, it might have been dark matter that killed the dinosaurs. Working through the background and consequences of this proposal, Randall shares with us the latest findings—established and speculative—regarding the nature and role of dark matter and the origin of the Universe, our galaxy, our Solar System, and life, along with the process by which scientists explore new concepts. In Dark Matter and the Dinosaurs, Randall tells a breathtaking story that weaves together the cosmos’ history and our own, illuminating the deep relationships that are critical to our world and the astonishing beauty inherent in the most familiar things. “Randall has woven a beautiful account of how life on Earth is intimately connected to the cosmos.” —The Daily Telegraph (UK)
NEW YORK TIMES BESTSELLER • COMING SOON TO APPLE TV+ • A “mind-blowing” (Entertainment Weekly) speculative thriller about an ordinary man who awakens in a world inexplicably different from the reality he thought he knew—from the author of Upgrade, Recursion, and the Wayward Pines trilogy “Are you happy with your life?” Those are the last words Jason Dessen hears before the kidnapper knocks him unconscious. Before he awakens to find himself strapped to a gurney, surrounded by strangers in hazmat suits. Before a man he’s never met smiles down at him and says, “Welcome back, my friend.” In this world he’s woken up to, Jason’s life is not the one he knows. His wife is not his wife. His son was never born. And Jason is not an ordinary college professor but a celebrated genius who has achieved something remarkable. Something impossible. Is it this life or the other that’s the dream? And even if the home he remembers is real, how will Jason make it back to the family he loves? From the bestselling author Blake Crouch, Dark Matter is a mind-bending thriller about choices, paths not taken, and how far we’ll go to claim the lives we dream of.
From a star theoretical physicist, a journey into the world of particle physics and the cosmos—and a call for a more liberatory practice of science. Winner of the 2021 Los Angeles Times Book Prize in Science & Technology A Finalist for the 2022 PEN/E.O. Wilson Literary Science Writing Award A Smithsonian Magazine Best Science Book of 2021 A Symmetry Magazine Top 10 Physics Book of 2021 An Entropy Magazine Best Nonfiction Book of 2020-2021 A Publishers Weekly Best Nonfiction Book of the Year A Kirkus Reviews Best Nonfiction Book of 2021 A Booklist Top 10 Sci-Tech Book of the Year In The Disordered Cosmos, Dr. Chanda Prescod-Weinstein shares her love for physics, from the Standard Model of Particle Physics and what lies beyond it, to the physics of melanin in skin, to the latest theories of dark matter—along with a perspective informed by history, politics, and the wisdom of Star Trek. One of the leading physicists of her generation, Dr. Chanda Prescod-Weinstein is also one of fewer than one hundred Black American women to earn a PhD from a department of physics. Her vision of the cosmos is vibrant, buoyantly nontraditional, and grounded in Black and queer feminist lineages. Dr. Prescod-Weinstein urges us to recognize how science, like most fields, is rife with racism, misogyny, and other forms of oppression. She lays out a bold new approach to science and society, beginning with the belief that we all have a fundamental right to know and love the night sky. The Disordered Cosmos dreams into existence a world that allows everyone to experience and understand the wonders of the universe.
This open access book offers an essential overview of brain, head and neck, and spine imaging. Over the last few years, there have been considerable advances in this area, driven by both clinical and technological developments. Written by leading international experts and teachers, the chapters are disease-oriented and cover all relevant imaging modalities, with a focus on magnetic resonance imaging and computed tomography. The book also includes a synopsis of pediatric imaging. IDKD books are rewritten (not merely updated) every four years, which means they offer a comprehensive review of the state-of-the-art in imaging. The book is clearly structured and features learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers navigate the text. It will particularly appeal to general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic expertise, as well as clinicians from other specialties who are interested in imaging for their patient care.
Diagnosis and Management in Parkinson's Disease: The Neuroscience of Parkinson's, Volume 1 provides a single source of material covering different scientific domains of neuropathology underlying this condition. The book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. It fills a much-needed gap as a "one-stop" synopsis of everything concerning the neurology and neuroscience related to Parkinson's disease, from chemicals and cells to individuals. The book is an invaluable resource for neuroscientists, neurologists, and anyone in the field. - Offers the most comprehensive coverage of a broad range of topics related to Parkinson's disease - Serves as a foundational collection for neuroscientists and neurologists on the biology of disease and brain dysfunction - Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding - Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations - Serves as a "one-stop" source for everything you need to know about Parkinson's disease
Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Fifth Edition provides a comprehensive introduction and reference to the foundations and key practical aspects relevant to the majority of neurologic and psychiatric disease. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands the informative, concise and critical tone of the first edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, and related professionals, and for the neuroscience and neurology research community. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling. Every chapter has been thoroughly revised or newly commissioned to reflect the latest scientific and medical advances by an international team of leading scientists and clinicians. The contents have been expanded to include disorders for which a genetic basis has been recently identified, together with abundant original illustrations that convey and clarify the key points of the text in an attractive, didactic format. Previous editions have established this book as the leading tutorial reference on neurogenetics. Researchers will find great value in the coverage of genomics, animal models and diagnostic methods along with a better understanding of the clinical implications. Clinicians will rely on the coverage of the basic science of neurogenetics and the methods for evaluating patients with biochemical abnormalities or gene mutations, including links to genetic testing for specific diseases. Comprehensive coverage of the neurogenetic foundation of neurological and psychiatric disease Detailed introduction to both clinical and basic research implications of molecular and genetic understanding of the brain Detailed coverage of genomics, animal models and diagnostic methods with new coverage of evaluating patients with biochemical abnormalities or gene mutations
Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it is an indispensable tool for all those working in this field. The context in which this book exists is that there is an increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information.