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In this volume the contributions of the 2nd International EBSA (European Biophysical Societies Association) Symposium devoted to the biophysical and biochemical aspects of the structure and interaction of cytoskeletal and extracellular proteins are presented. Topics such as supramolecular structure and organization, thermodynamics and kinetics of assembly, as well as the basic mechanisms of protein-protein interactions are discussed, and special emphasis is given to applied biophysical techniques.
Describes purification, activities, antibodies and genes for each protein.
Intended for postgraduate and professional researchers in biochemistry, biomedical sciences and cell biology, this text offers a guide to the extracellular matrix and adhesion proteins.
In this volume the contributions of the 2nd International EBSA (European Biophysical Societies Association) Symposium devoted to the biophysical and biochemical aspects of the structure and interaction of cytoskeletal and extracellular proteins are presented. Topics such as supramolecular structure and organization, thermodynamics and kinetics of assembly, as well as the basic mechanisms of protein-protein interactions are discussed, and special emphasis is given to applied biophysical techniques.
The biology of the 1980s and 1990s may well come to be remembered as the era of discovery of new proteins. Recent advances in molecular biology, genetics, and protein purification have conspired to accelerate the rate at which cellular proteins and their amino acid sequences are being identified. Now that the floodgate of discovery has been opened wide, the amount of new information on cellular proteins is exceeding most scientists' capacity for assimilation. At the same time, however, it has become imperative for research workers to expand their knowledge base because interactions between previously unconnected sets of proteins are being uncovered at such a rapid pace. These considerations have led Thomas E. Kreis and Ronald D. Vale to compile both the Guidebook to Cytoskeletal and Motor Proteins and the Guidebook to the Extracellular Matrix and Adhesion Proteins. Both books are distinguished by numerous outstanding features, including: concise compendiums of molecular information, consolidation of information from widely scattered sources, key references, clearly designed pages with many high-quality illustrations, and the first compilations of concise descriptions of the structure, function, and distribution of the proteins covered. Guidebook to Cytoskeletal and Motor Proteins covers actin and actin binding proteins, tubulin and associated proteins, the intermediate filaments, motor proteins, cytoskeletal anchor proteins, organelle membrane associated structural proteins, and other proteins. Introductory chapters provide overviews for each class of protein. Biological and structural attributes of about 200 individual proteins, or groups of closely related proteins, are concisely described by investigators who participated in their discovery or characterization. In addition, information regarding purification methods, assays of activity, and available reagents, together with a list key review and research articles, are included. Over 240 authors contributed to the entries. Guidebook to the Extracellular Matrix and Adhesion Proteins provides a concise compendium of the proteins found in the extracellular matrix and those known to be involved in cell-cell contact and adhesion. Organized alphabetically, it summarizes the key characteristics of these proteins and includes the same features--such as introductory chapters and contributions from the field's leading experts--that make its companion volume so essential. Designed to explain the each protein in an accessible manner, the book is also referenced for in-depth reading and provides excellent overviews.
The student of biological science in his final years as an undergraduate and his first years as a graduate is expected to gain some familiarity with current research at the frontiers of his discipline. New research work is published in a perplexing diversity of publications and is inevitably con cerned with the minutiae of the subject. The sheer number of research journals and papers also causes confusion and difficulties of assimilation. Review articles usually presuppose a background knowledge of the field and are inevitably rather restricted in scope. There is thus a need for short but authoritative introductions to those areas of modern biological research which are either not dealt with in standard introductory text books or are not dealt with in sufficient detail to enable the student to go on from them to read scholarly reviews with profit. This series of books is designed to satisfy this need. The authors have been asked to produce a brief outline of their subject assuming that their readers will have read and remembered much of a standard introductory textbook of biology. This outline then sets out to provide by building on this basis, the conceptual framework within which modern research work is progressing and aims to give the reader an indication of the problems, both conceptual and practical, which must be overcome if progress is to be maintained.
Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.
Vascular Pharmacology: Cytoskeleton and Extracellular Matrix, Volume 81, contains the latest information on the vascular cytoskeleton and extracellular matrix that is presented with helpful illustrations and supporting references by prominent scientists and highly-recognized experts in the vascular field. Topics of interest in this new release include Pharmacology of the Vascular Cytoskeleton and Extracellular Matrix, The Dynamic Actin Cytoskeleton in Smooth Muscle, The Role of the Actin Cytoskeleton in the Regulation of Vascular Inflammation, The Smoothelin Family of Proteins and the Smooth Muscle Cell Contractile Apparatus, Smooth Muscle Cytoskeletal Network Regulates Expression of the Profibrotic Genes PAI-1 and CTGF, and more. Presents a must-read book on the vascular cytoskeleton and extracellular matrix Contains up-to-date information on the structure, function and development of the vascular cell cytoskeleton Includes contributors from prominent scientists and highly-recognized experts with major accomplishments in the fields of the vascular cytoskeleton, extracellular matrix, mechanotransduction and vascular remodeling
Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.