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Cyclitols and Phosphoinositides covers the proceedings of the 1977 Conference on Cyclitols and Phosphoinositides, held at the Kellogg Center for Continuing Education, Michigan State University, East Lansing, Michigan. This book is organized into eight parts encompassing 43 chapters. The first parts describe the chemistry of cyclitols, inositol phosphates, and phosphoinositides. The subsequent parts explore the ubiquitous myoinositol and its phospholipids in animals, plants, yeast, bacteria, and molds; in various body parts, such as iris, brain, nerves, pineal, testis, lymphocytes, pancreas, parotid, retina, synapses, lysosomes; and the test tube. The last parts consider the mechanism of inositol biosynthesis and the meaning of increased phosphatidylinositol turnover in response to extracellular stimuli. This book will prove useful to research workers in the fields of organic chemistry, biochemistry, genetics, physiology, microbiology, pharmacology, botany, and nutrition.
This volume describes the current status of the biology of inositols and phosphoinositides with an emphasis on the development in the area since the publication of volume 26 in 1996 in this series. The progress made in dissecting the genetics, structure and evolution of the seminal enzyme for synthesis of inositol in the biological system has driven the understanding of the enzyme forward. With the current genomic and proteomic tools in place the new role of inositols, inositol phosphates and phosphoinositides in cell signaling or stress response has been explored. These advances are described in this volume and are expected to give new insights into the functional implications of inositol compounds across evolutionary diverse species.
The Chilton Conference on Inositol and Phosphoinositides, held on January 9-11, 1984 at Southwestern Medical School, University of Texas Health Science Center, Dallas, Texas, was the third in a series of conferences on cyclitols and phosphoinositides. The first took place in 1968 in New York [Ann. New York Acad. Sci. (1969), 765,508-819] and the second was held in 1977 in East Lansing, Michigan [eyclitols and Phosphoinositides, Wells, W. W. and Eisenberg, F. , eds. , (1978) Academic press, New York, pp. 1-607. ] In the interim since the previous conference, not only has the pace of research in the field accelerated markedly, but the physiological importance of phosphoinositide metabolism has become apparent to an increasing number of investigators from diverse fields in the life sciences. Thus it seemed to us timely for both recent and established workers in this area, as well as others whose interests impinged on it, to meet in order to disseminate new information, to review, and perhaps arrive at, a consensus of our current understanding of the role of inositol and phosphoinositides, and to establish new directions for research for the next few years. The expansion of the field since the last meeting made it mandatory to restrict the scope of the topics covered at the conference, primarily to aspects dealing with mammalian systems. We sincerely regretted the exclusion of recent research on cyclitols and phosphoinositides in microbes and plants and hope that these areas will be included in future conferences.
First multi-year cumulation covers six years: 1965-70.
Glycostructures play a highly diverse and crucial role in a myriad of organisms and systems in biology, physiology, medicine, and bioengineering and technology. Only in recent years have the tools been developed to partly understand the highly complex functions and chemistry behind them. In this set the editors present up-to-date information on glycostructures, their chemistry and chemical biology, in the form of a comprehensive survey. The text is accompanied by over 2000 figures, chemical structures and reaction schemes and more than 9000 references. The accompanying CD-ROM enables, besides text searches, searches for structures, schemes, and other information.