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Design and Analysis of Cross-Over Trials is concerned with a specific kind of comparative trial known as the cross-over trial, in which subjects receive different sequences of treatments. Such trials are widely used in clinical and medical research, and in other diverse areas such as veterinary science, psychology, sports science, and agriculture. The first edition of this book was the first to be wholly devoted to the subject. The second edition was revised to mirror growth and development in areas where the design remained in widespread use and new areas where it had grown in importance. This new Third Edition: Contains seven new chapters written in the form of short case studies that address re-estimating sample size when testing for average bioequivalence, fitting a nonlinear dose response function, estimating a dose to take forward from phase two to phase three, establishing proof of concept, and recalculating the sample size using conditional power Employs the R package Crossover, specially created to accompany the book and provide a graphical user interface for locating designs in a large catalog and for searching for new designs Includes updates regarding the use of period baselines and the analysis of data from very small trials Reflects the availability of new procedures in SAS, particularly proc glimmix Presents the SAS procedure proc mcmc as an alternative to WinBUGS for Bayesian analysis Complete with real data and downloadable SAS code, Design and Analysis of Cross-Over Trials, Third Edition provides a practical understanding of the latest methods along with the necessary tools for implementation.
This volume considers 'global mobility' as an alternative concept to 'international migration' in order to gain insights into international cooperation on movements of people across international borders.
'I am unaware of any textbook which provides such comprehensive coverage of the field and doubt that this work will be surpassed in the foreseeable future, if ever!' From the foreword by Robert C. Moellering, Jr., M.D, Shields Warren-Mallinckrodt Professor of Medical Research, Harvard Medical School, USA Kucers' The Use of Antibiotics is the leading major reference work in this vast and rapidly developing field. More than doubled in length compared to the fifth edition, the sixth edition comprises 3000 pages over 2-volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into 4 sections: antibiotics, anti-fungal drugs, anti-parasitic drugs and anti-viral drugs, and is highly structured for ease of reference.Within each section, each chapter is structured to cover susceptibility, formulations and dosing (adult and paediatric), pharmacokinetics and pharmacodynamics, toxicity and drug distribution, detailed discussion regarding clinical uses, a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with a vast number of contributors spanning Europe, Africa, Asia, Australia, South America, the US and Canada, the sixth edition adopts a truly global approach. It will remain invaluable for anyone using antimicrobial agents in their clinical practice and provides in a systematic and concise manner all the information required when treating infections requiring antimicrobial therapy. Kucers' The Use of Antibiotics is available free to purchasers of the books as an electronic version on line or on your desktop: It provides access to the entire 2-volume print material It is fully searchable, so you can find the relevant information you need quickly Live references are linked to PubMed referring you to the latest journal material Customise the contents - you can highlight sections and make notes Comments can be shared with colleagues/tutors for discussion, teaching and learning The text can also be reflowed for ease of reading Text and illustrations copied will be automatically referenced to Kucers' The Use of Antibiotics
The first edition of Design and Analysis of Cross-Over Trials quickly became the standard reference on the subject and has remained so for more than 12 years. In that time, however, the use of cross-over trials has grown rapidly, particularly in the pharmaceutical arena, and researchers have made a number of advances in both the theory and methods applicable to these trials. Completely revised and updated, the long-awaited second edition of this classic text retains its predecessor's careful balance of theory and practice while incorporating new approaches, more data sets, and a broader scope. Enhancements in the second edition include: A new chapter on bioequivalence Recently developed methods for analyzing longitudinal continuous and categorical data Real-world examples using the SAS system A comprehensive catalog of designs, datasets, and SAS programs available on a companion Web site at www.crcpress.com The authors' exposition gives a clear, unified account of the design and analysis of cross-over trials from a statistical perspective along with their methodological underpinnings. With SAS programs and a thorough treatment of design issues, Design and Analysis of Cross-Over Trials, Second Edition sets a new standard for texts in this area and undoubtedly will be of direct practical value for years to come.
"The distinction among slaves is as marked, as the classes of society are in any aristocratic community. Some refusing to associate with others whom they deem to be beneath them, in point of character, color, condition, or the superior importance of their respective masters." Henry Bibb, fugitive slave, editor, and antislavery activist, stated this in his Narrative of the Life and Adventures of Henry Bibb (1849). In William L. Andrews's magisterial study of an entire generation of slave narrators, more than 60 mid-nineteenth-century narratives reveal how work, family, skills, and connections made for social and economic differences among the enslaved of the South. Slave narrators disclosed class-based reasons for violence that broke out between "impudent," "gentleman," and "lady" slaves and their resentful "mean masters." Andrews's far-reaching book shows that status and class played key roles in the self- and social awareness and in the processes of liberation portrayed in the narratives of the most celebrated fugitives from U.S. slavery, such as Frederick Douglass, Harriet Jacobs, William Wells Brown, and William and Ellen Craft. Slavery and Class in the American South explains why social and economic distinctions developed and how they functioned among the enslaved. Noting that the majority of the slave narrators came from the higher echelons of the enslaved, Andrews also pays close attention to the narratives that have received the least notice from scholars, those from the most exploited class, the "field hands." By examining the lives of the most and least acclaimed heroes and heroines of the slave narrative, Andrews shows how the dividing edge of social class cut two ways, sometimes separating upper and lower strata of slaves to their enslavers' advantage, but at other times fueling pride, aspiration, and a sense of just deserts among some of the enslaved that could be satisfied by nothing less than complete freedom. The culmination of a career spent studying African American literature, this comprehensive study of the antebellum slave narrative offers a ground-breaking consideration of a unique genre of American literature.
Featuring a new package and an additional 60 pages of material, this revised edition of The Art of Feminism covers an even more impressive range of artworks, artists, movements, and perspectives. Since the debut of the original volume in 2018, The Art of Feminism has offered readers an in-depth examination of its subject that is still unparalleled in scope. The comprehensive survey traces the ways in which feminists—from the suffragettes and World War II–era workers through twentieth-century icons like Judy Chicago and Carrie Mae Weems to the contemporary cutting-edge figures Zanele Muholi and Andrea Bowers—have employed visual arts in transmitting their messages. With more than 350 images of art, illustration, photography, and graphic design, this stunning volume showcases the vibrancy of the feminist aesthetic over two centuries. The new, updated edition of the book features revised and expanded material in each of the book's original sections, as well as entirely new material dedicated to the art pieces that have shifted the landscape of feminist art today. This new material includes: women artists of the Bauhaus; grassroots and experimental curatorial efforts; a broader range of performance artists; and recent art shows and works, such as Kara Walker's Fons Americanus, which debuted at London's Tate Modern museum in 2020. UNIQUE IN SCOPE: The breadth and inclusiveness of this volume sets it apart and makes it the definitive book on international feminist art. The new edition brings the book into the current moment, ensuring that this groundbreaking volume remains relevant and fresh. It features an astonishing roster of artists, including: Barbara Kruger Sophie Calle Marina Abramovic Judy Chicago Faith Ringgold Cindy Sherman Ana Mendieta Zanele Muholi Mickalene Thomas Louise Bourgeois Shirin Neshat Andrea Bowers Pina Bausch JEB Amrita Sher-Gil Luchita Hurtado Ayana Jackson Patrisse Cullors EXPERT AUTHORS: Lead author Helena Reckitt has assembled a team of experts who are superbly qualified to unpack the rich history, power, and symbolism of feminist art for a new modern-day audience. UPDATED AND INCLUSIVE: This edition of the book features an even more diverse array of artists and artworks than the original, from the beautiful figurative paintings of Hungarian-Indian artist Amrita Sher-Gil to the thoroughly researched and extravagantly costumed self-portraits of American photographer Ayana Jackson. Perfect for: Feminists and activists Art history lovers College and graduate students
Small Animal Distal Limb Injuries provide the small and mixed animal practitioner with a definitive but practical, step-by-step guide to the management of soft tissue, orthopedic and athletic injuries of the distal limbs in dogs and cats.Includes specific coverage of injuries that occur from the carpal/tarsal areas to the digits of dogs and cats. A