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This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.
The cortex continues to be the subject of intense scientfic curiosity, as it has been for the past 30 years. It is the most highly developed part of the brain, yet the youngest in evolutionary terms. It is fundamental to human behavior, thinking, and self-understanding, and a study of its structure and performance must encompass aspects of anatomy, physiology, psychology, and neurology. This book providees a unique account of the structural and functional organization of the cerebral cortex from the point of view of one of the pioneers in the field. It is a revised and updated translation of the author's classic German text, and brings together for the first time the biological, psychological, and philosophical strands of enquiry relating to this fascinating area of the brain. The author's outstanding scientific reputation, combined with a subject of intense interest to researchers, will ensure that this book will be valued both for its scientific and historical contributions.
The cerebral cortex, especially that part customarily designated "neocortex," is one of the hallmarks of mammalian evolution and reaches its greatest size, relatively speaking, and its widest structural diversity in the human brain. The evolution of this structure, as remarkable for the huge numbers of neurons that it contains as for the range of behaviors that it controls, has been of abiding interest to many generations of neuroscientists. Yet few theories of cortical evo lution have been proposed and none has stood the test of time. In particular, no theory has been successful in bridging the evolutionary gap that appears to exist between the pallium of non mammalian vertebrates and the neocortex of mam mals. Undoubtedly this stems in large part from the rapid divergence of non mammalian and mammalian forms and the lack of contemporary species whose telencephalic wall can be seen as having transitional characteristics. The mono treme cortex, for example, is unquestionably mammalian in organization and that of no living reptile comes close to resembling it. Yet anatomists such as Ramon y Cajal, on examining the finer details of cortical structure, were struck by the similarities in neuronal form, particularly of the pyramidal cells, and their predisposition to laminar alignment shared by representatives of all vertebrate classes.
Cerebral Cortex is a comprehensive and detailed work covering the dual nature of the organization of the architecture and connections of the cerebral cortex. After establishing the evolutionary approach of the cerebral cortex's origin, the authors have systematically analyzed, in detail, the common principle underlying the structure and connections of sensory and motor systems. This important book describes the frontal, limbic, and multimodal association areas, as well as the long fiber pathways in a similar manner. The anatomical investigations have been complimented with current clinical and experimental observations, as well as neuroimaging studies. This unique approach, exploring the underlying principle of the architecture and connections of the cerebral cortex, has previously never been undertaken. In the concluding chapter of the book, the authors have provided the usefulness of such an approach for future investigations. Cerebral Cortex provides extensive illustrations, along with historical references to each sensory, motor and association systems.
The Parietal Lobe, Volume 151, the latest release from the Handbook of Clinical Neurology series, provides a foundation on the neuroanatomy, neurophysiology and clinical neurology/neuropsychology of the parietal lobe that is not only applicable to both basic researchers and clinicians, but also to students and specialists who are interested in learning more about disorders brought on by damage or dysfunction. Topics encompass the evolution, anatomy, connections, and neurophysiology, the major neurological and neuropsychological deficits and syndromes caused by damage, the potential for improvement via transcranial stimulation, and the role of the parietal in the cerebral networks for perception and action. - Provides a broad overview of the neuroanatomy, neurophysiology and clinical neurology of this region of the cortex - Offers additional insights regarding the role of the parietal in the cerebral networks for perception and action - Addresses the most frequent complications associated with damage, including somatosensory, perceptual, language, and memory, deficits, pain, optic ataxia, spatial neglect, apraxia, and more - Edited work with chapters authored by global leaders in the field - Presents the broadest, most expert coverage available
"This book is primarily written for neuroscientists who will always be interested in the role of calcium in the internal neuronal environment. The objectives are well met. The authors are credible authorities in the field and are the most appropriate to discuss calcium in neuronal development...Through multiple excellent quality pictures, this book shows evidence of the potential roles of calcium in the modulation of development as well as on the determination of programmed cell death. " Review from Doody's Notes
The aim of this book is to provide insight into the principles of operation of the cerebral cortex. These principles are key to understanding how we, as humans, function. There have been few previous attempts to set out some of the important principles of operation of the cortex, and this book is pioneering. The book goes beyond separate connectional neuroanatomical, neurophysiological, neuroimaging, neuropsychiatric, and computational neuroscience approaches, by combining evidence from all these areas to formulate hypotheses about how and what the cerebral cortex computes. As clear hypotheses are needed in this most important area of 21st century science, how our brains work, I have formulated a set of hypotheses about the principles of cortical operation to guide thinking and future research. The book focusses on the principles of operation of the cerebral cortex, because at this time it is possible to propose and describe many principles, and many are likely to stand the test of time, and provide a foundation for further developments, even if some need to be changed. In this context, I have not attempted to produce an overall theory of operation of the cerebral cortex, because at this stage of our understanding, such a theory would be incorrect or incomplete. However, many of the principles described will provide the foundations for more complete theories of the operation of the cerebral cortex. This book is intended to provide a foundation for future understanding, and it is hoped that future work will develop and add to these principles of operation of the cerebral cortex. The book includes Appendices on the operation of many of the neuronal networks described in the book, together with simulation software written in Matlab.
This volume of Cerebral Cortex is dedicated to Sir John Eccles, who was an active member of the advisory board for the series until his death in May 1997. His input as to what topics should be covered in future volumes of this series will be sorely missed. The present volume is concerned with neurodegenerative disorders and age related changes in the structure and function of the cerebral cortex, a topic that has attracted increasing interest as longevity and the number of aged individuals in the population increase. Although much of the research on the neurodegenerative effects of aging has been centered on Alzheimer's disease, most of the aging popu lation will not be afflicted by this disease. They will, however, be affected by the consequences of normal aging, so the first few chapters of this volume are con cerned with that topic. Chapter 1, by Marilyn S. Albert and Mark B. Moss, gives an account of the cognitive changes that accompany normal human aging. Chapter 2, by Mark B.
The cerebral cortex, especially that part customarily designated "neocortex," is one of the hallmarks of mammalian evolution and reaches its greatest size, relatively speaking, and its widest structural diversity in the human brain. The evolution of this structure, as remarkable for the huge numbers of neurons that it contains as for the range of behaviors that it controls, has been of abiding interest to many generations of neuroscientists. Yet few theories of cortical evo lution have been proposed and none has stood the test of time. In particular, no theory has been successful in bridging the evolutionary gap that appears to exist between the pallium of nonmammalian vertebrates and the neocortex of mam mals. Undoubtedly this stems in large part from the rapid divergence of non mammalian and mammalian forms and the lack of contemporary species whose telencephalic wall can be seen as having transitional characteristics. The mono treme cortex, for example, is unquestionably mammalian in organization and that of no living reptile comes close to resembling it. Yet anatomists such as Ramon y Cajal, on examining the finer details of cortical structure, were struck by the similarities in neuronal form, particularly of the pyramidal cells, and their predisposition to laminar alignment shared by representatives of all vertebrate classes.
Experts review the latest research on the neocortex and consider potential directions for future research. Over the past decade, technological advances have dramatically increased information on the structural and functional organization of the brain, especially the cerebral cortex. This explosion of data has radically expanded our ability to characterize neural circuits and intervene at increasingly higher resolutions, but it is unclear how this has informed our understanding of underlying mechanisms and processes. In search of a conceptual framework to guide future research, leading researchers address in this volume the evolution and ontogenetic development of cortical structures, the cortical connectome, and functional properties of neuronal circuits and populations. They explore what constitutes “uniquely human” mental capacities and whether neural solutions and computations can be shared across species or repurposed for potentially uniquely human capacities. Contributors Danielle S. Bassett, Randy M. Bruno, Elizabeth A. Buffalo, Michael E. Coulter, Hermann Cuntz, Stanislas Dehaene, James J. DiCarlo, Pascal Fries, Karl J. Friston, Asif A. Ghazanfar, Anne-Lise Giraud, Joshua I. Gold, Scott T. Grafton, Jennifer M. Groh, Elizabeth A. Grove, Saskia Haegens, Kenneth D. Harris, Kristen M. Harris, Nicholas G. Hatsopoulos, Tarik F. Haydar, Takao K. Hensch, Wieland B. Huttner, Matthias Kaschube, Gilles Laurent, David A. Leopold, Johannes Leugering, Belen Lorente-Galdos, Jason N. MacLean, David A. McCormick, Lucia Melloni, Anish Mitra, Zoltán Molnár, Sydney K. Muchnik, Pascal Nieters, Marcel Oberlaender, Bijan Pesaran, Christopher I. Petkov, Gordon Pipa, David Poeppel, Marcus E. Raichle, Pasko Rakic, John H. Reynolds, Ryan V. Raut, John L. Rubenstein, Andrew B. Schwartz, Terrence J. Sejnowski, Nenad Sestan, Debra L. Silver, Wolf Singer, Peter L. Strick, Michael P. Stryker, Mriganka Sur, Mary Elizabeth Sutherland, Maria Antonietta Tosches, William A. Tyler, Martin Vinck, Christopher A. Walsh, Perry Zurn