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Pathogenic Coronaviruses of Humans and Animals: SARS, MERS, COVID-19, and Animal Coronaviruses with Zoonotic Potential provides relevant information about common human coronaviruses that may mutate to increase their virulence. The addition of animal coronaviruses allows awareness of not only the potential of zoonotic transmission of coronaviruses from wild animals such as bats and rodents, but also from domestic agricultural and companion animals. The book opens with an introductory chapter on viruses, the immune system, coronaviruses, and their classifications, prevention and protection. Sections also cover history, disease, causative virus, immune response, diagnosis, treatment, prevention and surveillance. The book's remaining chapters discuss coronaviruses with possible zoonotic transmission of domestic, semi-domestic animals and companion animals. It concludes with future perspectives of coronavirus mutations, modeling, protective measures and a discussion around pandemics and infectious diseases from around the globe. - Covers SARS-CoV, MERS-CoV and SARS-CoV-2 as well as coronaviruses with possible zoonotic transmission of domestic, semi-domestic animals and companion animals - Complements previous studies by bringing together information that compares human and animal coronaviruses - Includes a glossary and coronavirus disease overviews of humans and animals
Coronaviruses, the latest volume in the Advances in Virus Research series first published in 1953, covers a diverse range of in-depth reviews, providing a valuable overview of the field. This series is a valuable resource for virologists, microbiologists, immunologists, molecular biologists, pathologists, and plant researchers. - Contains contributions from leading authorities in virus research - Provides comprehensive reviews for general and specialist use - Presents the first and longest-running review series in virology
Interest in the coronaviruses has never been greater. Their economic impact is considerable as they infect humans, livestock, poultry and companion animals. Murine hepatitis virus (MHV) infection of the mouse and rat central nervous systems are the subject of intense study; these investigations are providing insights into the potential role of viruses in human neurological diseases and, more generally, into mechanisms causing neurological damage. The single-stranded, positive-sense RNA genomes of two species of these enveloped viruses (IBV and MHV) have been cloned completely and one of them (lBV) sequenced in its entirety, revealing a genome size of some 27000 nucleotides. This has made possible more incisive investigations into the nature of those polypeptides, encoded by more than half of the genome, which are likely to contribute, in the main, to RNA polymerase/replicase activity. Intriguingly, ribosomal frameshifting is exhibited within the mRNA coding for these polypeptides. The cloning/sequencing phase of coronavirology for which the 1980's will be partly remembered, has provided a sound framework for furthex: studies of the virus structural proteins and also some provocative insights relevant to these studies. The large spike glycoprotein(s), responsible for membrane fusion and bearing important antigenic sites, varies amazingly in length and composition both within as well as between coronavirus species. Receptors on host cells have been identified. The integral membrane glycoprotein (M) has been shown to use internal hydrophobic sequences to direct translocation within membranes.
While many scientists believed influenza would cause the next great pandemic, no one was prepared for the new strain of coronavirus that appeared in 2019. SARS-CoV-2, the virus that causes COVID-19, has infiltrated every country and put global public health and the economy at risk. Health-care systems have been pushed to the limit as protective gear, life-saving equipment, tests, and vaccines are scarce and in high demand. From the initial infection to the widespread impact on daily life, Understanding Coronaviruses examines the intricacies of SARS-CoV-2 and COVID-19 and how they compare to previous viruses and pandemics.
This volume represents the most authoritative source of information on coronaviruses collected together in a single work. Chapters provide an up-to-date account of the molecular biology of coronaviruses and toroviruses as well as the pathogenesis of coronavirus and torovirus infections. Discussions emphasize the unique features of the coronaviridae and examine the concept of a `coronavirus-like' superfamily. Academic researchers and their students as well as clinicians and veterinarians with an interest in coronavirus-related disease will benefit from this comprehensive reference.
-SARS has received much attention and coverage by the media and has a high impact on the public making this a hot research topic for scientists. -
With the huge experience more than a decade as an author, co-author and reviewer, the editors decided to share the knowledge on the current problem which is COVID-19. The information about corona virus and its impact on various aspects including society, economy and the quality of life is clearly given in this book. The virus has been spread across the globe and troubling the mankind. Till date, several countries have been damaged literally not only with the lives, but also with the loss of economy, mental ability, psychological issues etc. More variants of this virus have also been observed with more severity and damage to the humans. This pandemic affected the life of the people socially, economically, physically, and mentally. The human loss through this pandemic cannot be recovered. The awareness about the virus, its transmission and precautions, causative ways, different methods of drugs etc. needs to be provided to the layman and as whole to the community. This book mainly aims to answer all the above raised issues and worked out thoroughly. Thus, this book is a comprehensive information with basic knowledge about different aspects surrounding COVID-19. Layman, Young researchers, basic science graduates, medical and clinical sciences graduates, students, hospital workers, nurses, doctors, engineers, and every professional area of people can benefit from this book.
Proceedings of the VIIth International Symposium held in Segovia, Spain, May 10-15, 1997
This detailed new edition compiles fully updated practical methodologies and approaches for diagnosticians and researchers working toward a better understanding of animal coronaviruses. The book explores vital techniques in virus isolation, diagnostic approaches via the detection of viral nucleic acids or proteins, serology, disease-targeted animal species models, and next-generation sequencing and bioinformatics. Written for the invaluable Springer Protocols Handbooks series, chapters contain readily reproducible laboratory protocols as well as expert tips on troubleshooting and avoiding known pitfalls. Thorough and hands-on, Animal Coronaviruses, Second Edition will help readers design and carry out their increasingly important projects in clinical research, diagnostics, disease surveillance, and epidemiological study involving this family of viruses.
This book provides fundamental information on various techniques for the detection of SARS-CoV-2 including reverse transcriptase (RT) PCR, loop-mediated isothermal amplification, immunodiagnostic tests, and CRISPR-Cas. It reviews various testing kits and detection methodologies that are currently being used for the detection of SARS-CoV-2 and examines strategies for the post-treatment detection and monitoring of SARS-CoV-2. Further, it assesses the diagnostic potential of several SARS-CoV-2 proteins; and analyzes their structural determinants and immunogenicity. In turn, the book evaluates the potential of CRISPR-Cas 12-based assays for the detection of SARS-CoV-2 using RNA extracted from patients. Lastly, it discusses the use of miniaturized biosensors for the detection of other types of coronavirus.