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The global response to COVID-19 has demonstrated the importance of vigilance and preparedness for infectious diseases, particularly influenza. There is a need for more effective influenza vaccines and modern manufacturing technologies that are adaptable and scalable to meet demand during a pandemic. The rapid development of COVID-19 vaccines has demonstrated what is possible with extensive data sharing, researchers who have the necessary resources and novel technologies to conduct and apply their research, rolling review by regulators, and public-private partnerships. As demonstrated throughout the response to COVID-19, the process of research and development of novel vaccines can be significantly optimized when stakeholders are provided with the resources and technologies needed to support their response. Vaccine Research and Development to Advance Pandemic and Seasonal Influenza Preparedness and Response focuses on how to leverage the knowledge gained from the COVID-19 pandemic to optimize vaccine research and development (R&D) to support the prevention and control of seasonal and pandemic influenza. The committee's findings address four dimensions of vaccine R&D: (1) basic and translational science, (2) clinical science, (3) manufacturing science, and (4) regulatory science.
High strength fibre composites (FRPs) have been used with civil structures since the 1980s, mostly in the repair, strengthening and retrofitting of concrete structures. This has attracted considerable research, and the industry has expanded exponentially in the last decade. Design guidelines have been developed by professional organizations in a nu
This report presents recommended construction specifications to facilitate highway agencies' use of bonded fiber-reinforced polymer (FRP) composites for the repair and retrofit of concrete structures. These specifications cover the construction of FRP systems used as externally bonded or near surface-mounted reinforcement to enhance axial, shear, or flexural strength of a concrete member. These specifications are supplemented by a construction process control manual that provides a program for assuring a consistent and uniform control of quality and regulatory requirements.
The repair of deteriorated, damaged and substandard civil infrastructures has become one of the most important issues for the civil engineer worldwide. This important book discusses the use of externally-bonded fibre-reinforced polymer (FRP) composites to strengthen, rehabilitate and retrofit civil engineering structures, covering such aspects as material behaviour, structural design and quality assurance.The first three chapters of the book review structurally-deficient civil engineering infrastructure, including concrete, metallic, masonry and timber structures. FRP composites used in rehabilitation and surface preparation of the component materials are also reviewed. The next four chapters deal with the design of FRP systems for the flexural and shear strengthening of reinforced concrete (RC) beams and the strengthening of RC columns. The following two chapters examine the strengthening of metallic and masonry structures with FRP composites. The last four chapters of the book are devoted to practical considerations in the flexural strengthening of beams with unstressed and prestressed FRP plates, durability of externally bonded FRP composite systems, quality assurance and control, maintenance, repair, and case studies.With its distinguished editors and international team of contributors, Strengthening and rehabilitation of civil infrastructures using fibre-reinforced polymer (FRP) composites is a valuable reference guide for engineers, scientists and technical personnel in civil and structural engineering working on the rehabilitation and strengthening of the civil infrastructure. - Reviews the use of fibre-reinforced polymer (FRP) composites in structurally damaged and sub-standard civil engineering structures - Examines the role and benefits of fibre-reinforced polymer (FRP) composites in different types of structures such as masonry and metallic strengthening - Covers practical considerations including material behaviour, structural design and quality assurance
This chapter presents dozens of select environmental engineering applications of fiber-reinforced polymer (FRP) composite materials with emphasis on their environmental benefits, followed by discussions on durability of composites. Significance of design codes and specifications in promoting and advancing the applications of FRP composites is addressed. With ever increasing attention toward a sustainable built environment, FRP composites have potential to be selected as a material of choice because of the performance and design advantages of FRPs.
The first textbook on the design of FRP for structural engineering applications Composites for Construction is a one-of-a-kind guide to understanding fiber-reinforced polymers (FRP) and designing and retrofitting structures with FRP. Written and organized like traditional textbooks on steel, concrete, and wood design, it demystifies FRP composites and demonstrates how both new and retrofit construction projects can especially benefit from these materials, such as offshore and waterfront structures, bridges, parking garages, cooling towers, and industrial buildings. The code-based design guidelines featured in this book allow for demonstrated applications to immediately be implemented in the real world. Covered codes and design guidelines include ACI 440, ASCE Structural Plastics Design Manual, EUROCOMP Design Code, AASHTO Specifications, and manufacturer-published design guides. Procedures are provided to the structural designer on how to use this combination of code-like documents to design with FRP profiles. In four convenient sections, Composites for Construction covers: * An introduction to FRP applications, products and properties, and to the methods of obtaining the characteristic properties of FRP materials for use in structural design * The design of concrete structural members reinforced with FRP reinforcing bars * Design of FRP strengthening systems such as strips, sheets, and fabrics for upgrading the strength and ductility of reinforced concrete structural members * The design of trusses and frames made entirely of FRP structural profiles produced by the pultrusion process
Advanced Fibre-reinforced Polymer (FRP) Composites for Structural Applications, Second Edition provides updates on new research that has been carried out on the use of FRP composites for structural applications. These include the further development of advanced FRP composites materials that achieve lighter and stronger FRP composites, how to enhance FRP integrated behavior through matrix modification, along with information on pretension treatments and intelligence technology. The development of new technology such as automated manufacturing and processing of fiber-reinforced polymer (FRP) composites have played a significant role in optimizing fabrication processing and matrix formation. In this new edition, all chapters have been brought fully up-to-date to take on the key aspects mentioned above. The book's chapters cover all areas relevant to advanced FRP composites, from the material itself, its manufacturing, properties, testing and applications in structural and civil engineering. Applications span from civil engineering, to buildings and the energy industry. - Covers all areas relevant to advanced FRP composites, from the material itself, its manufacturing, properties, testing and applications in structural engineering - Features new manufacturing techniques, such as automated fiber placement and 3D printing of composites - Includes various applications, such as prestressed-FRP, FRP made of short fibers, continuous structural health monitoring using advanced optical fiber Bragg grating (FBG), durability of FRP-strengthened structures, and the application of carbon nano-tubes or platelets for enhancing durability of FRP-bonded structures
Strengthening of Concrete Structures Using Fiber Reinforced Polymers (FRP): Design, Construction and Practical Applications presents a best practice guide on the structural design and strengthening of bridge structures using advanced Fiber Reinforced Polymer (FRP) composites. The book briefly covers the basic concepts of FRP materials and composite mechanics, while focusing on practical design and construction issues, including inspection and quality control, paying special attention to the differences in various design codes (US, Japan, and Europe) and recommendations. At present, several design guides from the US, Japan, and Europe are available. These guidelines are often inconsistent and do not cover all necessary design and inspection issues to the same degree of detail. This book provides a critical review and comparison of these guidelines, and then puts forward best practice recommendations, filling a significant gap in the literature, and serving as an important resource for engineers, architects, academics, and students interested in FRP materials and their structural applications. Written from a practitioner's point-of-view, it is a valuable design book for structural engineers all over the world. - Includes a large quantity of design examples and structural software to facilitate learning and help readers perform routine design - Provides recommendations for best practices in design and construction for the strengthening of bridge structures using advanced fiber-reinforced polymer (FRP) composites - Presents comprehensive guidelines on design, inspection, and quality control, including laboratory and field testing information
TRB's National Cooperative Highway Research Program (NCHRP) Report 655: Recommended Guide Specification for the Design of Externally Bonded FRP Systems for Repair and Strengthening of Concrete Bridge Elements examines a recommended guide specification for the design of externally bonded Fiber-Reinforced Polymer (FRP) systems for the repair and strengthening of concrete bridge elements. The report addresses the design requirements for members subjected to different loading conditions including flexure, shear and torsion, and combined axial force and flexure. The recommended guide specification is supplemented by design examples to illustrate its use for different FRP strengthening applications.