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This book provides the reader with comprehensive information on the interactions between diabetes and a wide range of comorbid conditions and on disease management in such patients. It has the aim of empowering health care providers in their daily battle against the disease and its consequences. Diabetes has been identified by WHO and the United Nations as a medical emergency because of the increase in its global prevalence, which may reach one billion in three to four decades if the trend remains unchanged. Despite improved care that is helping to prolong life, diabetes impacts substantially on the quality of life of those affected and kills or disables several million people each year. The disease is systemic because all organs, tissues, and cells suffer in the presence of hyperglycemia and are damaged by the diabetic milieu. Unfortunately, most patients with diabetes will consequently experience chronic diabetic complications. This book will be of value for all physicians and nurses who care for patients with diabetes and face the challenge of treating hyperglycemia and related acute and chronic complications.
"Diabetes mellitus is one of the major causes of morbidity and mortality in the modern world. Persistent hyperglycaemia is responsible for several complications of diabetes, such as diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, diabetic cardiomyopathy, diabetic autonomic neuropathy, diabetic ketoacidosis, diabetic foot ulcer, gestational diabetes, and diabetic mastopathy. With the advancement of technology, several new drugs have been developed for treatment of diabetes and diabetic complications. Moreover, alternative and complementary medicines have also been employed to manage diabetes and its associated complications. Despite the availability of a plethora of therapeutic agents, the management of diabetes and diabetic complications is an uphill battle associated with several limitations. Various leading research groups across the world are investing billions of dollars to develop impeccable solutions for the treatment of diabetes and diabetic complications. This book focuses on the understanding of recent advancements in the pathogenesis of diabetes and diabetic complications, the molecular basis of the disease and recent advancements in diabetic treatment. The chapters are specifically dedicated to different complications associated with diabetes. Moreover, recent advances in treatments and medications in clinical trials for these complications are explained. Some chapters are dedicated to the use of herbal medicines, alternative and complementary therapy and personalized medicines. Furthermore, the role of epigenetics in diabetic complications is described, as well as the role of antidiabetic drugs and their interactions. Due to its widespread prevalence, diabetes is presently considered a pandemic. This book provides contemporary information to researchers and health care practitioners about diabetes and diabetic complications, which may pave the way for designing new strategies to manage diabetes and diabetic complications. Moreover, the insights on alternative and complementary medicines will help in providing a background for inclusion of these medicines as an important therapeutic option for treatment of diabetes"--
This edition of Diabetes: Chronic Complications provides both the experienced and trainee endocrinologist with easy-to-read, up-to-date practical guidance on the management of the many complications that can result from the onset of diabetes, such as kidney failure, cardiovascular disease, retinal failure, and cerebrovascular disease. Reflecting the rapid developments currently taking place in the field, the second edition introduces a brand-new section on liver complications in diabetes, additional material on mental health complications in the section on diabetes and the brain, coverage of dyslipidaemia and hypertension in the section on diabetes and the heart, five MCQ's in each section to help improve clinical skills, and a case study and key points summary box in every chapter.
Chronic Complications of Diabetes Mellitus: Current Outlook and Novel Pathophysiological Insights provides a holistic view of the disease, discussing not only its classical complications but also the under recognized and managed conditions associated with diabetes. Chapters also discuss advances in our understanding of the genomic architecture of diabetes complications and how precision medicine can be used to personalize their management. Endocrinologists, diabetologists, primary care physicians and researchers interested in complications of diabetes mellitus and cutting-edge information will find this to be a comprehensive tome on the topic. Diabetes complications include pathological changes usually related to the vascular system and classical target organs. However, there are also nonclassical complications independent or partially independent from vascular damage that are often overlooked. Describes pathophysiology, clinical aspects and treatment of complications of diabetes, including nonclassical complications such as diabetic bone disease and diabetic cardiomyopathy Addresses and discusses challenges in the management of diabetes complications, including prevention and therapeutic strategies Presents up-to-date, thoroughly referenced information for clinicians, researchers and other healthcare providers
Diabetes and hypertension have evolved as two of the modern day epidemics affecting millions of people around the world. These two common co-morbidities lead to substantial increase in cardiovascular disease, the major cause of morbidity and mortality of adults around the world. In Diabetes and Hypertension: Evaluation and Management, a panel of renowned experts address a range of critical topics -- from basic concepts in evaluation and management of diabetes and hypertension, such as dietary interventions, to evaluation and management of secondary hypertension in clinical practice. Other chapters focus on high cardiovascular risk populations such as those with coronary heart disease, chronic kidney disease and minority patients. In addition, evolving concepts and new developments in the field are presented in other chapters, such as prevention of type 2 diabetes and the epidemic of sleep apnea and its implication for diabetes and hypertension evaluation and management. An important title covering two of the most troubling disorders of our time, Diabetes and Hypertension: Evaluation and Management will provide the busy practitioner with cutting edge knowledge in the field as well as practical information that can translate into better care provided to the high-risk population of diabetics and hypertensive patients.
Diabetes is one of the leading causes of morbidity and mortality worldwide. Major complications include nephropathy, neuropathy, retinopathy and heart disease, which affect thousands of diabetics every year. The prevention and treatment of such complications encompass pharmacological, surgical and educational approaches, all of which need to be coordinated for optimal management of people with diabetes. This user-friendly new edition of Diabetes - Chronic Complications (previously called Diabetic Complications) has been completely revised and updated to reflect the rapid developments currently taking place in the field. Each chapter describes the epidemiology, aetiology and management of a particular complication and discusses the organisation and delivery of care. Includes all the major chronic complications of diabetes Presents a practical approach to the treatment of diabetes complications Written by world’s leading experts in the field Features algorithms for screening and treatment of diabetes complications
Diabetes mellitus is a complex, progressive disease, which is accompanied by multiple complications. It is a metabolic disorder of the endocrine system and listed among the most common disorders in both developed and developing countries. It has a global metabolic epidemic and it is estimated that the number of people affected by the disease will rise from the current 150 to 230 million by 2025. Hyperglycaemia is a characteristic feature of diabetes mellitus and chronic hyperglycaemia could lead to long-term complications in the eyes, kidneys, nerves, heart and blood vessels. Interestingly, this book examines the pathophysiology and selected complications in diabetes mellitus.
​Public and political concern about the increasing prevalence of diabetes has prompted major concern about treatment of patients with the condition. Foot complications are some of the commonest causes of hospitalisation of people with diabetes and if not treated well often lead to amputation. There is evidence that 85% of these amputations can be prevented by better understanding of the problem and by multi-disciplinary teams working more effectively together. This has been recognised and NICE have recently published guidelines on diabetic foot complications as have Diabetes UK and NHS Diabetes. These have been successful in raising awareness of the problem but the local multi-disciplinary teams need clear practical advice on how to manage the foot in diabetes and deliver high quality care. With the current interest in improving outcomes for patients with foot complications this is an ideal time to make a practical evidence-based handbook available. This book will provide clear practical guidelines on how to manage all aspects of the foot in diabetes as well as an in-depth analysis of the most recent evidence. The book will be based on care pathways with algorithms for each section so it would be of practical value in any clinic in primary or secondary care. It will appeal to a wide range of health care professionals treating people with diabetes: vascular surgeons and trainees, orthopaedic surgeons, diabetes specialist nurses, podiatrists and tissue viability nurses.​
Now in its fifth edition, the Textbook of Diabetes has established itself as the modern, well-illustrated, international guide to diabetes. Sensibly organized and easy to navigate, with exceptional illustrations, the Textbook hosts an unrivalled blend of clinical and scientific content. Highly-experienced editors from across the globe assemble an outstanding set of international contributors who provide insight on new developments in diabetes care and information on the latest treatment modalities used around the world. The fifth edition features an array of brand new chapters, on topics including: Ischaemic Heart Disease Glucagon in Islet Regulation Microbiome and Diabetes Diabetes and Non-Alcoholic Fatty Liver Disease Diabetes and Cancer End of Life Care in Diabetes as well as a new section on Psychosocial aspects of diabetes. In addition, all existing chapters are fully revised with the very latest developments, including the most recent guidelines from the ADA, EASD, DUK and NICE. Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates Via the companion website, readers can access a host of additional online materials such as: 200 interactive MCQ's to allow readers to self-assess their clinical knowledge every figure from the book, available to download into presentations fully searchable chapter pdfs Once again, Textbook of Diabetes provides endocrinologists and diabetologists with a fresh, comprehensive and multi-media clinical resource to consult time and time again.
Diabetes mellitus has become epidemic on a global scale, and millions of new cases are diagnosed every year. The epidemic of diabetes mellitus is expected to result in one of the steepest rises in human morbidity and mortality ever observed outside of wartime. Insulin resistance is a hallmark of pre-diabetes and type 2 diabetes mellitus, and is characterized by impaired insulin-signaling transduction. Authoritative and comprehensive, Lipoproteins in Diabetes Mellitus details the many changes wrought by insulin resistance and diabetes mellitus on lipid and lipoprotein metabolism. The book begins by summarizing the various techniques to measure lipoproteins and their subclasses. The mechanisms by which insulin resistance and diabetes mellitus increase risk for atherosclerosis, diabetic retinopathy, and diabetic nephropathy are then explored in detail. Finally, the effects of lifestyle modification and the results of clinical trials using established and investigational drugs are discussed. An invaluable contribution to the literature, Lipoproteins in Diabetes Mellitus is a comprehensive reference on the clinical and scientific aspects of lipoproteins in diabetes. It will have a long-lasting and significant effect on the medical management of people with diabetes.