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There exists an extreme variability in the biochemical properties of animal organisms. Each species, each individual, in fact each cell type of a multicellular animal has its own molecular characters. This advanced text- and reference book deals with the molecular structures of body substances and the chemical processes of metabolism for the first time throughout the whole animal kingdom from the protozoans to the higher vertebrates. The biochemical variation is explained as adaptation to particular environmental conditions or as the result of phylogenetic diversification. The fascinating insights into the fundamental mechanisms and the time course of evolution that have been gained by the analysis of molecular data are extensively described. More than 4600 actual references give the reader access to the original literature.
Comparative Biology of the Normal Lung, Second Edition, offers a rigorous and comprehensive reference for all those involved in pulmonary research. This fully updated work is divided into sections on anatomy and morphology, physiology, biochemistry, and immunological response. It continues to provide a unique comparative perspective on the mammalian lung. This edition includes several new chapters and expanded content, including aging and development of the normal lung, mechanical properties of the lung, genetic polymorphisms, the comparative effect of stress of pulmonary immune function, oxygen signaling in the mammalian lung and much more. By addressing scientific advances and critical issues in lung research, this 2nd edition is a timely and valuable work on comparative data for the interpretation of studies of animal models as compared to the human lung. - Edited and authored by experts in the field to provide an excellent and timely review of cross-species comparisons that will help you interpret and compare data from animal studies to human findings - Incorporates lung anatomy and physiology, cell specific interactions and immunological responses to provide you with a single and unique multidisciplinary source on the comparative biology of the normal lung - Includes new and expanded content on neonatal and aged lungs, developmental processes, cell signaling, antioxidants, airway cells, safety pharmacology and much more - Section IV on Physical and Immunological Defenses has been significantly updated with 9 new chapters and an increased focus on the pulmonary immunological system
Comparative Biochemistry of Parasites contains the proceedings of an international symposium organized by the Janssen Research Foundation and held at Janssen Pharmaceutica in Belgium on September 1-3, 1971. The symposium reviewed progress in the understanding of the physiology and biochemistry of parasites such as protozoa and helminths. Organized into 34 chapters, this volume begins with an overview of early research on parasite biochemistry before turning to a discussion of antischistosomal drugs and their biochemical effects on parasites. The reader is then introduced to the biochemistry of carbohydrates in nematodes and cestodes; neurotransmitters in trematodes; pharmacological aspects and biochemical effects of tetramisole; the mechanism of action of berenil (Diminazene) and related compounds; and dihydrofolate reductases in parasitic protozoa and helminths. Other chapters focus on the loss of fatty acid biosynthesis in flatworms, the cytochrome system in Kinetoplastidae, oxidative phosphorylation in Moniezia mitochondria, and the role of non-heme iron in cestode respiration. Scientists, particularly physiologists and biochemists, will find this book an invaluable source of information on parasite physiology and biochemistry.
All animals face the possibility of food limitation and ultimately starvation-induced mortality. This book summarizes state of the art of starvation biology from the ecological causes of food limitation to the physiological and evolutionary consequences of prolonged fasting. It is written for an audience with an understanding of general principles in animal physiology, yet offers a level of analysis and interpretation that will engage seasoned scientists. Each chapter is written by active researchers in the field of comparative physiology and draws on the primary literature of starvation both in nature and the laboratory. The chapters are organized among broad taxonomic categories, such as protists, arthropods, fishes, reptiles, birds, and flying, aquatic, and terrestrial mammals including humans; particularly well-studied animal models, e.g. endotherms are further organized by experimental approaches, such as analyses of blood metabolites, stable isotopes, thermobiology, and modeling of body composition.
This book presents various examples of how advanced fluorescence and spectroscopic analytical methods can be used in combination with computer data processing to address different biochemical questions. The main focus is on evolutionary biochemistry and the description of biochemical and metabolic issues; specifically, the use of pulse amplitude modulated fluorescence (PAM) for the functional analysis of the cellular state, as well as results obtained by means of the derivative spectroscopy method characterizing structural reorganization of a cell under the influence of external factors, are discussed. The topics presented here will be of interest to biologists, geneticists, biophysicists and biochemists, as well as experts in analytical chemistry, pharmaceutical chemistry and radio chemistry and radio activation studies with protonen and alpha-particles. It also offers a valuable resource for advanced undergraduate and graduate students in biological, physical and chemical disciplines whose work involves derivative spectrophotometry and PAM-fluorescence.
When survival is challenged by the cold, animals react by employing both behavioral and physiological solutions. Depending on the magni tude of the cold stress and the nature of the adjustment, simple avoidance or sophisticated capacity or resistance compensations may be used. Thus, migration, shelter seeking, metabolic and insulative compen sation, torpor, and freezing avoidance and tolerance are successful tac tics used by diverse groups of animals. To understand and appreciate the benefits of these tactics, it is necessary to examine not only the well being of the whole animal but also their basic underlying mechanisms. In ad dition, it is also of fundamental importance to grasp how seasonal cold affects the survivorship and reproductive success of populations when confronted by a general reduction in primary productivity and an elevated energy cost for maintenance (e. g. in endotherms). In this regard, a synthetic overview which integrates aspects of cell biology, biochem istry, physiology, neurobiology, behavior, and population biology should be a fruitful approach in providing a holistic understanding on how animals adapt to cold. The present volume is an attempt to achieve such an overview; its objective is to provide a depth and breadth of coverage that is essential to a full appreciation of animal adaptation to cold. It is the hope of the contributing authors that this book will serve as an effective reference text for all senior undergraduate and graduate students as well as research scientists with an interest in cold physiology.
This book describes the role of the neutrophil in infection and inflammation and provides an up-to-date review of the biochemistry and physiology of this cell, highlighting the mechanisms by which they seek out and destroy pathogenic microorganisms. The development of these cells during haematopoiesis is described and the mechanisms that lead to the production of reactive oxidants and the intracellular signal transduction systems that lead to the cell's activation are reviewed. The book also discusses recent discoveries concerning the role of cytokines in the regulation of neutrophil function together with the importance of the neutrophil as a generator of inflammatory cytokines. Finally, there is a description of the biochemical defects that give rise to some of the neutrophil-associated human diseases.
This is an updated and expanded version of Professor Smyth's earlier work The Physiology of Cestodes (1969) which presented for the first time an overview of the physiology of these parasitic worms, many species of which cause serious, often fatal, diseases in man and domestic animals. Recent advances in investigative techniques, such as immunocytochemistry and in vitro culture, which have increased immensely our understanding of these organisms, are presented. The biochemical coverage has been expanded to include the spectacular advances in molecular biology in recent years. The book also shows how cestodes are increasingly being recognized as valuable models for transport and cell differentiation. Medical and veterinary students as well as students in parasitology and zoology will find this book an invaluable resource.
Originally published in 1927, this book examines the composition and function of the heart in a range of animals. Clark examines how the function of the heart differs between members of the same species who are not of the same size and the differences in heart structure between cold- and warm-blooded animals.
This book discusses biochemical adaptation to environments from freezing polar oceans to boiling hot springs, and under hydrostatic pressures up to 1,000 times that at sea level. Originally published in 1984. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.