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Unlike the bulk majority of publications on philosophy of science and research ethics, which are authored by professional philosophers and intended for philosophers, this book has been written by a research practitioner and intended for research practitioners. It is distinctive by its integrative approach to methodological and ethical issues related to research practice, with special emphasis of mathematical modelling and measurement, as well as by attempted application of engineering design methodology to moral decision making. It is also distinctive by more than 200 real-world examples drawn from various domains of science and technology. It is neither a philosophical treaty nor a quick-reference guide. It is intended to encourage young researchers, especially Ph.D. students, to deeper philosophical reflection over research practice. They are not expected to have any philosophical background, but encouraged to consult indicated sources of primary information and academic textbooks containing syntheses of information from primary sources. This book can be a teaching aid for students attending classes aimed at identification of methodological and ethical issues related to technoscientific research, followed by introduction to the methodology of analysing dilemmas arising in this context.
This book seeks to narrow two gaps: first, between the widespread use of case studies and their frequently 'loose' methodological moorings; and second, between the scholarly community advancing methodological frontiers in case study research and the users of case studies in development policy and practice. It draws on the contributors' collective experience at this nexus, but the underlying issues are more broadly relevant to case study researchers and practitioners in all fields. How does one prepare a rigorous case study? When can causal inferences reasonably be drawn from a single case? When and how can policy-makers reasonably presume that a demonstrably successful intervention in one context might generate similarly impressive outcomes elsewhere, or if massively 'scaled up'? No matter their different starting points – disciplinary base, epistemological orientation, sectoral specialization, or practical concerns – readers will find issues of significance for their own field, and others across the social sciences. This title is also available Open Access.
As the field of general surgery continues to expand, the diagnostic and therapeutic pathways are becoming more complex. The diagnostic modalities available to the clinician can be both very helpful but also overwhelming considering the findings can often determine the scope of treatment for a patient. This text will take the major pathologies of the systems commonly studied in general surgery and present them in a unique format based upon algorithms. The algorithms will begin with the clinical presentation of the patient, work its way through the various diagnostic modalities available to the surgeon, and finally allow the physician to make a decision regarding treatment options based upon various patterns in the algorithms. This text will become a very useful resources for surgeons as it allows complex clinical pathways to be conveniently organized in logical algorithms. It will become a concise yet comprehensive manual to assist in clinical decision making. All algorithms will be reviewed by experts in their field and include the most up-to-date clinical and evidence-based information. Clinical Algorithms in General Surgery provides a useful resource for surgeons in clinical practice as well as surgical residents, and surgical attendings who are preparing for board examinations. See sample algorithm in Attachments.
The work presented in this PhD dissertation is the first search at CMS for Higgs bosons produced in association with top quarks (ttH) in a final state consisting of only jets. The results presented in this book uncover a new class of ttH events that will help us elucidate our understanding of the Yukawa sector interactions between the Higgs boson and the top quark. Despite this being the most common decay signature for ttH, a large contamination of SM backgrounds makes it the most challenging for extracting a signal from data. The PhD thesis presents many sophisticated tools and techniques that were developed in order to overcome these challenges. These tools pave the way for future analyses to investigate other standard model and beyond-standard model physics.
This book presents two analyses, the first of which involves the search for a new heavy charged gauge boson, a so-called W' boson. This new gauge boson is predicted by some theories extending the Standard Model gauge group to solve some of its conceptual problems. Decays of the W' boson in final states with a lepton (l± = e± , μ±) and the corresponding (anti-)neutrino are considered. Data collected by the ATLAS experiment in 2015 at a center of mass energy of √s =13 TeV is used for the analysis. In turn, the second analysis presents a measurement of the double-differential cross section of the process pp->Z/gamma^* + X -> l^+l^- + X, including a gamma gamma induced contribution, at a center of mass energy of sqrt{s} = 8 TeV. The measurement is performed in an invariant mass region of 116 GeV to 1500 GeV as a function of invariant mass and absolute rapidity of the l^+l^-- pair, and as a function of invariant mass and pseudorapidity separation of the l^+l^-- pair. The data analyzed was recorded by the ATLAS experiment in 2012 and corresponds to an integrated luminosity of 20.3/fb. It is expected that the measured cross sections are sensitive to the PDFs at very high values of the Bjorken-x scaling variable, and to the photon structure of the proton.
Novel Approaches to Colorectal Cancer, Volume 151 in the Advances in Cancer Research series, is composed of 11 reviews covering state-of-the-art research relating to the etiology, diagnosis, prevention and treatment of colorectal cancer. The book's chapters were written by recognized experts in the field, and include sections on molecular biomarkers in diagnosis and therapy, the interplay of diet, lifestyle, and the microbiome, early-age onset disease, mutational signature analysis, challenges in early detection, immunotherapy, organoid technology, the role of epigenetic alterations, disparities in minority populations, field carcinogenesis, and cancer as an evolutionary process. Each of these topics provides novel insights and concepts on various aspects of the nature of colorectal cancer, offering new opportunities for the management of a major source of cancer incidence and mortality. - Provides information on the timely nature of the included topics, which represent the most current concepts and approaches in cancer research - Offers outstanding and original reviews on colorectal cancer research - Provides the authority and expertise of the authors, all of whom are highly recognized and conducting state-of-the-art investigations in cancer, with this release focusing on colorectal cancer
This informative monograph describes the technological evolution of silicon detectors and their impact on high energy particle physics. The author here marshals his own first-hand experience in the development and also the realization of the DELPHI, CDF II and the CMS tracking detector. The basic principles of small strip- and pixel-detectors are presented and also the final large-scale applications. The Evolution of Silicon Detector Technology acquaints readers with the manifold challenges involving the design of sensors and pushing this technology to the limits. The expert will find critical information that is so far only available in various slide presentation scattered over the world wide web. This practical introduction of silicon sensor technology and its day to day life in the lab also offers many examples to illustrate problems and their solutions over several detector generations. The new edition gives a detailed overview of the silicon sensor technology used at the LHC, from basic principles to actual implementation to lessons learned.
This book highlights the most complete characterization of the Higgs boson properties performed to date in the "golden channel," i.e., decay into a pair of Z bosons which subsequently decay into four leptons. The data collected by the CMS experiment in the so-called Run-II data-taking period of the LHC are used to produce an extensive set of results that test in detail the predictions of the Standard Model. Given the remarkable predictive power of the SM when including the Higgs boson, possible new physics will require even more extensive studies at higher statistics. A massive upgrade of the detectors is necessary to maintain the current physics performance in the harsh environment of the High-Luminosity LHC (HL-LHC) project, expected to start by the end of 2027. The CMS Collaboration will replace the current endcap calorimeters with a High Granularity Calorimeter (HGCAL). The HGCAL will be the very first large-scale silicon-based imaging calorimeter ever employed in a high-energy physics experiment. This book presents the results of the analysis of the test beam data collected with the first large-scale prototype of the HGCAL. The results of this analysis are used to corroborate the final design of the HGCAL and its nominal physics performance expected for the HL-LHC operations.
This thesis focuses on the theoretical foundation of the Standard Model valid up to the Planck scale, based on the current experimental facts from the Large Hadron Collider. The thesis consists of two themes: (1) to open up a new window of the Higgs inflation scenario, and (2) to explore a new solution to the naturalness problem in particle physics. In the first area, on the Higgs inflation scenario, the author successfully improves a large value problem on a coupling constant relevant to the Higgs mass in the Standard Model, in which the coupling value of the order of 105 predicted in a conventional scenario is reduced to the order of 10. This result makes the Higgs inflation more attractive because the small value of coupling is natural in the context of ultraviolet completion such as string theory. In the second area, the author provides a new answer to the naturalness problem, of why the cosmological constant and the Higgs mass are extremely small compared with the Planck scale. Based on the baby universe theory originally proposed by Coleman, the smallness of those quantities is successfully explained without introducing any additional new particles relevant at the TeV energy scale.
The latest of the 'Lepton Photon' symposium, one of the well-established series of meetings in the high-energy physics community, was successfully organized at the South Campus of Sun Yat-sen University, Guangzhou, China, from August 7-12, 2017, where physicists around the world gathered to discuss the latest advancements in the research field.This proceedings volume of the Lepton Photon 2017 collects contributions by the plenary session speakers and the posters' presenters, which cover the latest results in particle physics, nuclear physics, astrophysics, cosmology, and plans for future facilities.