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Gordon Rhea's gripping fourth volume on the spring 1864 campaign-which pitted Ulysses S. Grant against Robert E. Lee for the first time in the Civil War-vividly re-creates the battles and maneuvers from the stalemate on the North Anna River through the Cold Harbor offensive. Cold Harbor: Grant and Lee, May 26-June 3, 1864 showcases Rhea's tenacious research which elicits stunning new facts from the records of a phase oddly ignored or mythologized by historians. In clear and profuse tactical detail, Rhea tracks the remarkable events of those nine days, giving a surprising new interpretation of.
Leland Hall (1883-1957) was the author of "Sinister House" and "They Seldom Speak."
"During his many long nights in the lab, scientist Andy O'Hara has plenty of time to wonder about the mysterious and beautiful Gina, first glimpsed in a lit window across the courtyard. He does not realize she is consumed by her vaccine research, concerned about her biotech company's financial problems, and about to become the prime target of animal rights activists. She is also distracted by a charming pharmaceutical mogul who offers funding for her work and a glamorous escape from her past mistakes." "When Andy finally meets Gina, his monotonous life starts to unravel. Soon he becomes embroiled in an increasingly complex web of deception as he scrambles to discover his rival's true intentions. When Gina abruptly disappears, Andy sets off to find her. But is it too late? Is there a more sinister reason behind Gina's involvement with the company? Is Gina's vaccine all it appears to be? And is Andy ready to acknowledge that there is more to life than work?"--BOOK JACKET.
Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Phage-display technology has begun to make critical contributions to the study of molecular recognition. DNA sequences are cloned into phage, which then present on their surface the proteins encoded by the DNA. Individual phage are rescued through interaction of the displayed protein with a ligand, and the specific phage is amplified by infection of bacteria. Phage-display technology is powerful but challenging and the aim of this manual is to provide comprehensive instruction in its theoretical and applied so that any scientist with even modest molecular biology experience can effectively employ it. The manual reflects nearly a decade of experience with students of greatly varying technical expertise andexperience who attended a course on the technology at Cold Spring Harbor Laboratory. Phage-display technology is growing in importance and power. This manual is an unrivalled source of expertise in its execution and application.
"Lab Dynamics is a book about the challenges to doing science and dealing with the individuals involved, including oneself. The authors, a scientist and a psychotherapist, draw on principles of group and behavioral psychology but speak to scientists in their own language about their own experiences. They offer in-depth, practical advice, real-life examples, and exercises tailored to scientific and technical workplaces on topics as diverse as conflict resolution, negotiation, dealing with supervision, working with competing peers, and making the transition from academia to industry." "This is a uniquely valuable contribution to the scientific literature, on a subject of direct importance to lab heads, postdocs, and students. It is also required reading for senior staff concerned about improving efficiency and effectiveness in academic and industrial research."--BOOK JACKET
The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals. This book is a major resource for those working in the field, as well as being a suitable text for advanced undergraduate and graduate courses on gene regulation.