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Earth, 2508 A.D. Humans have spread across the six arms of the Milky Way Galaxy. The Unified Authority controls Earth’s colonies with an iron fist and a powerful military—a military made up almost entirely of clones… Private first-class Wayson Harris was raised in a U.A. orphanage among thousands of clones born and bred to be the ultimate soldiers. But Harris isn’t like the other Marines: he has a mind of his own. He figures he’s paying for that independent streak when his first assignment out of boot camp is the smallest Marine outpost in the whole U.A. When a rogue general surfaces, the remote desert world Harris thought was a dead-end posting becomes anything but. Fighting off the general’s raid gains Harris a promotion. But it also brings him to the attention of some unfriendly U.A. leaders. They have their own plans for the military—plans Harris disrupts by his very existence. For in an army of clones, the one unforgivable sin is to be different…
Rhim and Kremer’s state-of-the-art volume on Human Cell Transformation: Role of Stem Cells and the Microenvironment highlights the latest findings on the current state of human cell transformation model systems and provides the insight into the molecular and cellular changes involved in the conversion of normal cells to neoplastic cells. Chapters cover all recently developed novel human cell models. In addition, the rapidly growing fields of knowledge regarding not only stem cells in cancer progression, but also the role of the microenvironments in human carcinogenesis are discussed. A wealth of topics is presented including: · Derivation of epithelial, fibroblastic, and hematopoietic in vitro model systems · Oncogenes · Tumor suppressor genes · Viral transformation · In vitro model systems for viral, chemical and radiation carcinogenesis · Cell aging · The multistep nature of human carcinogenesis · The role of stem cells and the microenvironment in tumorigenesis · The genes involved in multistep carcinogenesis Unique in both scope and focus – devoted solely to human cell transformation systems – Human Cell Transformation: Role of Stem Cells and the Microenvironment provides unparalleled, in-depth coverage for cancer researchers, cell and molecular biologists, hematologists, virologists, and workers in related fields. Essential reading for everyone who needs to be kept up-to-date in this fast-paced area! Features ؠ Multistep models ؠ Breast cancer/Stem cells ؠ Prostate cancer/Stem cells ؠ Multistep / Genes
The inflorescence of the monoecious maize plant is unique among the Gramineae in the sharp separation of the male and female structures. The male tassel at the terminus of the plant most often sheds pollen before the visual appearance of the receptive silks of th the female ear at a lateral bud, normally at the 10 leaf [I]. Earlier studies examined the ontogeny of the growing tissues beginning with the embryo in the kernel through to the obvious protuberances of the growing point as the kernel germinates. The differentiated developing soon-to-become tassel and the lateral bulges that develop into the ears on the lateral buds become apparent very early in the germinating kernel [2, 3, 46]. A certain number of cells are destined for tassel and ear development [8]. As the plant develops, there is a phase transition [\3, 16] from the vegetative lateral buds to the reproductive lateral buds. This change in phase has been ascribed to genotypic control as evidenced in the differences among different genotypes in the initiation of the reproductive [I]. The genetic control of tassel and ear initiation has been gleaned from anatomical observations. Lejeune and Bernier [I2] found that maize plants terminate the initiation of additional axillary meristems at the time of tassel initiation. This would indicate that the top-most ear shoot is initiated on the same day as the initiation of tassel development and this event signals the end of the undifferentiated growing point.
Volume 16 of Advances in Microbial Ecology has a difficult history. Nearly halfway through its completion, Gwynfryn Jones had to resign as managing edi tor for health reasons, and he asked me to take over. I want to thank Gwyn for his dedicated work in this publication series, and wish him all the best for the future. After the change in editorship, some authors had to be encouraged on rather short notice to provide their chapters in order to make appearance of this volume possible within a reasonable period of time. Nonetheless, I think that the articles we present with this volume represent an enjoyable collection of up-to-date con tributions to microbial ecology. In my own understanding, microbial ecology com prises the elucidation of microbial activities in natural or semi natural environ ments, including physiology, biochemistry, population dynamics, and interactions with all the biotic and abiotic environmental conditions microbes encounter. This comprises studies on single organisms in defined cultures in an ecological per spective, the analysis of microbial activities in complex environments, as well as the development of concepts for the interactions of microorganisms with the world in which they live. Last but not least, microbial ecology is not an exotic science studied exclusively in remote places untouched by human beings.
Cytogenetics of Cells in Culture is a compendium of papers that deals with techniques to detect patterns of DNA replication, cellular control mechanisms, and chromosome analyses with automated instrumentation. Some papers discuss the effects of cell hybridization and of noxious substances such as radiation, chemical agents, and viruses on chromosomal patterns. Other papers focus on the influence of altered chromosomal complement on the survival of cells to long-term tissue culture or to ionizing radiation treatment. A couple of papers points out that naturally occurring chromosomal abnormalities in mammalian populations are relatively rare and are not necessarily associated with physical defects or disease. One paper notes that chromosomes in cells with different functions have different patterns of replication in which the changes are small and hidden. The chromosomes will usually be neutralized showing little of the characteristic pattern of replication or condensation during the early cleavage stages, that will later change into differentiated characteristic ways for each tissue type. Another paper describes chromosome breakage associated with viruses and DNA inhibitors. The compendium can prove beneficial for biochemists, micro-biologists, cellular researchers, and academicians involved in the study of cellular biology or physiology.
In a state-of-the-art synthesis of basic science and clinical practice, Roy Smith and a distinguished panel of researchers and clinicians review GH regulation and its action at the molecular level, and describe the basis for GH deficiency and the use of GH as therapy in a variety of clinical situations. The clinical presentation moves beyond the treatment of GH-deficient children to include the genetics of GH-deficiency, GH-deficiency in adults, osteoporosis, Syndrome X, sleep quality, GH in AIDS patients, GHRH in clinical studies. Timely and innovative, Human Growth Hormone: Research and Clinical Practice will benefit both basic and clinical researchers, as well as those clinical endocrinologists who want to use growth hormone not only in treating children, but also in treating adult disorders, including those associated with metabolic disease.
The objective of this volume is to provide a preliminary data base for Candida albicans plus serve as a reference for the genetic methods now available for the manipulation of several species in the genus Candida. This comprehensive review focuses primarily on C. albicans and includes reference data on the types and complementation status of mutations isolated in C. albicans, preliminary recombination mapping, chromosome analysis, physical measurements of DNA content and complexity, mitochondrial genome mapping, and analyses of restriction fragment length polymorphisms. It discusses a variety of genetic techniques in relation to current research questions aimed at virulence factors, dimorphism, and the potential use of Candida strains in biotechnology processes. This up-to-date publication is an indispensable resource for everyone who is involved with microbiology, genetics, and molecular and cellular biology.