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Clinical and Basic Neurogastroenterology and Motility is a state-of-the-art, lucidly written, generously illustrated, landmark publication that comprehensively addresses the underlying mechanisms and management of common adult and pediatric motility disorders. These problems affect 50% of the population and include conditions such as dysphagia, achalasia, gastroesophageal reflux disease, gastroparesis, irritable bowel syndrome (IBS), gas and bloating, SIBO, constipation and fecal incontinence. The book brings together international experts and clinician scientists, epitomizing their years of wisdom into a concise yet practical text that is delivered in two distinct sections, basic and clinical. It fulfills a large unmet need, and bridges a long-awaited knowledge gap among trainees, clinicians, scientists, nurses and technicians, earnestly engaged in this field. - First of its kind text that covers both basic and clinical aspects, bridging the knowledge gap, and providing a bench to bedside approach for management of common disorders - Discusses the latest concepts and basic principles of neurogastroenterology and motility, and how the gut and brain interact in the genesis of functional gastrointestinal and motility disorders - Provides an illustrated and practical text on hot topics written by leading adult and pediatric gastroenterology experts across the globe - Includes an accompanying more detailed web version of the text with free access to future podcasts
This multi-authored book covers most aspects of evaluation of gastrointestinal motility – a field that has been expanding in recent times largely due to advances in diagnostic modalities; coupled with this, new evidences supporting best practices have increased the interest among clinical gastroenterologists, researchers, teachers and trainees in gastrointestinal motility and its disorders. New advances in the field of evaluation of functional bowel diseases and motility disorders, such as high-resolution manometry, 24-h pH impedance monitoring, Bravo capsule pH-metry, barostat, balloon expulsion test, barium and MR defecography, biofeedback, hydrogen breath tests, motility capsule (smartpill) etc. have significantly expanded the scope and outcome of treating these disorders. The chapters have been contributed by a well-conversant group of experts from the global academia, including India, Singapore, Thailand, Korea and Australia, integrating the body of knowledge on evaluation methods with evidence of best practices for the management of motility disorders. A chapter on how to set-up a manometry laboratory provides key information for clinicians and researchers who are planning to start working in this area. With 11 chapters in the book supported with numerous tables, flow charts, schematic diagrams and images, professionals will find it an essential reading. ​
This volume provides a comprehensive and up-to-date theoretical review and practical guide on pediatric gastrointestinal motility and functional disorders. The latest edition includes extensively revised and new chapters to reflect the rapidly growing field of pediatric neurogastroenterology. New topics covered include neurobiology of pain in children, functional oropharyngoesophageal assessment, dysautonomia, and psychotropic drugs. The text also features instructive illustrations, photographs, and tables. Written by world-renown experts in the field, Pediatric Neurogastroenterology: Gastrointestinal Motility and Functional Disorders in Children, Second Edition is a valuable resource for pediatric gastroenterologists, adult gastroenterologists, pediatricians, and all professionals involved in the treatment and management of children with such disorders.
"Studying rare genetic and molecular diseases of gut motility provides an understanding of their underlying mechanisms and may provide insights on the mechanisms or management of more common illnesses. For example, constipation affects 1 in 5 people 65 years or older and 1 in 10 people younger than 65 years, and slow-transit constipation or colonic inertia is responsible for approximately 10% of referrals of patients with constipation to gastroenterologists and, among all patients with constipation, is the cause in probably 1%. Insights on the pathophysiology and mechanisms of constipation are provided by studying Hirschsprung disease, mitochondrial cytopathy, or multiple endocrine neoplasia type 2B. These diseases are used to illustrate the congenital diseases of the enteric neuromuscular apparatus"--
The research and outcomes presented in this book gather evidence concerning both the pathogenesis and treatment of functional dyspepsia. It provides the latest information on this common non-organic disease, indicating its characteristic pathogenesis based on the brain-gut interaction and micro-environment and evidence gleaned from clinical treatment. Since the pathogenesis is associated with psychology, neurology, endocrinology and bacteriology in addition to gastroenterological physiology, it is often intractable and finding a suitable treatment rationale is challenging. Furthermore, the pathogenesis varies around the world and the efficacy of treatment using standard drugs varies among different populations worldwide; accordingly, this book highlights evidence gained in clinical trials in Japan. Functional Dyspepsia is a milestone produced by respected experts. Addressing unique topics and new findings of treatment including challenging and/or future rationales, it offers an invaluable resource for general clinicians, gastroenterologists, and basic researchers alike.
Handbook of Gastrointestinal Motility and Functional Disorders is a user-friendly handbook that reviews the latest and most up-to-date information on the evaluation of symptoms and diagnostic tests of GI motility and functional GI disorders and a practical approach on how to treat these disorders. Each chapter is written by an international expert in the field who was carefully chosen for his or her renowned scientific and clinical expertise. The book brings together the essence of science and art in the practice of neurogastroenterology and GI motility. The chapters are enriched with algorithms, tables, and figures to enhance learning and readability. Each chapter follows a specific outline; chapters on symptoms follow the format of definition, pathophysiology, and evaluation of the symptoms, whereas the chapters on specific disorders follow the format of definition, diagnosis, and treatment. This allows for quick reading of the various chapters and to gain up-to-date knowledge of the topic. Each chapter also includes extensive color pictures and illustrations of each test involved and descriptions of how to perform and interpret the motility tests that are incorporated into patient care decisions. Handbook of Gastrointestinal Motility and Functional Disorders by Drs. Satish S. C. Rao, Henry P. Parkman, and Richard W. McCallum will be useful for practicing physicians, junior academicians, GI fellows, young faculty, motility laboratory personnel, surgeons, internists, physician assistants, family practitioners, and nurse practitioners who all encounter the common problems of dysphagia, heartburn, nausea, vomiting, abdominal pain, irritable bowel syndrome, constipation, and fecal incontinence in their daily practice. The update on management and therapy completes the Handbook of Gastrointestinal Motility and Functional Disorders and explains how to integrate this diagnostic information into decision making, and how to translate this to day-to-day patient care.
Gastroparesis: Pathophysiology, Clinical Presentation, Diagnosis and Treatment is a reference book providing a centralized source of data on gastroparesis collected over the last decade. Contents include the pathophysiology, clinical presentation, diagnostic recommendations and treatment options for gastroparesis. The reference is split into broad subsections, with the strategy of first focusing on the key features of the disease and then turning to controversies, recent developments, patient support resources, the spectrum of treatment – including medical and surgical - and future directions. Chapters will include coverage of important topics like autonomic neuropathy, the brain-gut axis, potential pathophysiological advances at the cellular level, diagnostic and therapeutic options specifically targeted at the pylorus, and the evaluation of the female predominance in gastroparesis. This is a must-have resource for scientists looking to find the next step in their research as well as healthcare professionals ranging from Gastroenterologists to Internists, Surgeons, Nutritionists, Psychiatrists, and Psychologists, Residents and Medical Students who struggle with how to optimally take care of their gastroparetic patients. - Provides a comprehensive overview of what is known regarding the pathophysiology, clinical presentation, diagnostic considerations and treatment options for gastroparesis - Includes key updates made in the last decade, including the progress made by the NIH Gastroparesis Consortium - Presents both sides of key controversies in the field, including the debate between classification of gastroparesis versus functional dyspepsia - Fully reviews the major advances in pharmacologic agents for therapy, both anti-emetics and prokinetics - Extensive update on the "Pyloric Revolution" and our understanding of the pathophysiology of gastroparesis and how the focus on the pylorus has literally transformed our treatment strategy with an emphasis on both surgical and endoscopic advances in addressing pyloric dysfunction
This comprehensive yet concise guide to the diagnosis and management of IBS is divided into four main parts: Overview, Diagnosis, Symptom-specific Treatment, and What's Next in IBS. Each chapter includes a summary of key points, and most chapters include cases and multiple choice questions for rapid review. Clinicians who manage patients with IBS will want to keep this dependable reference close at hand.
Brain-Gut Interactions serves as a reference source and stimulus for expanded research efforts aimed at unravelling the pathophysiology of brain-gut interactions. Within the general framework of brain-gut interactions, it covers the various areas in which this growing interdisciplinary field has evolved. Topics discussed in this volume include the topography and morphology of afferent and efferent connections between the gut and the medulla and hypothalamic nuclei, the role of afferent and efferent pathways in the regulation of gastrointestinal function, the brain's regulation of gastrointestinal secretory and motor function, and the function of peripheral and central cholecystokinin in the mechanisms of satiety. The final section of this book focuses on topics such as stress, emesis, visceral pain, and brain-related disorders of the intestine based on experimental and clinical data. Students and investigators working with brain-gut interactions, gastroenterologists, psychologists, and psychiatrists will find this book to be an essential reference resource.