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Written by nearly 60 of the world's leading investigators in this rapidly expanding field, this state-of-the-art reference furnishes detailed presentations on the basic science and clinical aspects of cilia, mucus, and mucociliary interactions. Providing stimulating coverage of the latest information in a single source, Cilia, Mucus, and Mucociliary Interactions discusses the genetic determinants of mucociliary system structure and function explains ciliary wave activity in cell-cell communication elucidates many of the key physiological processes in ciliary regulation reveals possible means of treating irregularities in mucus secretion and clearance improves understanding of clinical syndromes, including abnormalities pertaining to nasal sinuses, upper and lower airways, and the systemic role of cilia approaches the clinical management of mucociliary dysfunction logically using currently available diagnostic and therapeutic techniques and much more! Containing bibliographic citations, tables, equations, drawings, and photographs, this exhaustive guide is essential reading for physiologists, pulmonologists, otolaryngologists, pediatricians, microbiologists, basic scientists, and graduate and medical school students in these disciplines.
This book details advances in research regarding cilia, mucus, and mucociliary clearance, examining changes in mucus expression and goblet cell metaplasia, and assessing the ability of the mucociliary system to respond to abnormalities. Recognizes that cilia and dynein arms play pivotal roles in developing mammalian embryos! Examines the rol
Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st
Known for its clear readability, thorough coverage, and expert authorship, Murray & Nadel's Textbook of Respiratory Medicine has long been the gold standard text in the fast-changing field of pulmonary medicine. The new 7th Edition brings you fully up to date with newly expanded content, numerous new chapters, a new editorial team, and extensive updates throughout. It covers the entire spectrum of pulmonology in one authoritative point-of-care reference, making it an ideal resource for pulmonary physicians, fellows, and other pulmonary practitioners. - Offers definitive, full-color coverage of basic science, diagnosis, evaluation, and treatment of the full range of respiratory diseases. - Provides detailed explanations of each disease entity and differential diagnoses with state-of-the-art, evidence-based content by global leaders in the field. - Contains a newly expanded section on common presentations of respiratory disease, plus new chapters on COVID-19, asthma and obesity, airplane travel, lung cancer screening, noninvasive support of oxygenation, lung microbiome, thoracic surgery, inhaled substances, treatment of lung cancer, and more. - Covers hot topics such as vaping; advanced ultrasound applications and procedures; interventional pulmonology; immunotherapy; lung cancer targeted therapy; outbreaks, pandemics and bioterrorism; point-of-care ultrasound; use of high-flow oxygen, and more. - Includes extensively reorganized sections on basic science, pleural disease, and sleep, with new chapters and approaches to the topics. - Features more than 1,450 anatomic, algorithmic, and radiologic images (400 are new!) including CT, PET, MR, and HRCT, plus extensive online-only content: 200 procedural and conceptual videos plus audio clips of lung sounds. - Brings you up to date with the latest respiratory drugs, mechanisms of action, indications, precautions, adverse effects, and recommendations, with increased emphasis on algorithms to illustrate decision making. - Enhanced eBook version included with purchase. Your enhanced eBook allows you access to all of the text, figures, reporting templates, and references from the book on a variety of devices.
This wide-ranging, comprehensive reference presents the latest developments in aerosol science and interactions between particles and the respiratory tract-utilizing an inter-disciplinary approach that integrates advances in physics, chemistry, and engineering with the epidemiological and biomedical sciences, and focusing on the dynamics of particl
Traditional methods of medical education and training are changing rapidly. This volume integrates the printed text--as provided by leading experts in science and medicine--with multimedia applications using desktop conferencing and the Internet in the delivery of instruction. The Department of Biochemistry and Molecular Biology at The George Washington University Medical Center, with the support of an unrestricted educational grant from the Healthcare Education Department of Glaxo Welcome, Inc. , has created a distance-learning lecture series on the Internet for continuing medical education. In this lecture series, leading scientists and physicians discussed the most current as well as future projected treatments of prominent afflictions of mankind. These chosen speakers, who are at the forefront of research and treatment in the field of biomedicine, build a structural framework for the audience in their field of expertise, and from there looked into their crystal ball and discussed their view of the future. The lectures, approximately one hour in length, were broadcast live from The George Washington University Medical Center in Washington, D. C. as part of the Department of Medicine Grand Rounds. These lectures will be available on the Internet until 2001. In partnership with Medical Consumer Media, the lectures were simultaneously broadcast live around the world via the Internet with real-time audio streaming and digitized 35mm slide presentation. The lecture format was designed to foster questions which went beyond basic science and current treatments.
Conceptually unsavoury, airway mucus is vital to homeostasis in the respiratory tract. In contrast, when abnormal, mucus contributes significantly to the pathophysiology of a number of severe bronchial diseases, including asthma, chronic bronchitis and cystic fibrosis. This volume provides wide ranging and in-depth coverage of the scientific and clinical aspects of airway mucus. It commences with introductory chapters which address the biochemical and molecular biological basis of airway mucus and continues with comprehensive coverage of the various physiological and rheological aspects of respiratory secretions. The clinical aspects of the topic are then considered, with chapters discussing the involvement of mucus secretions in bacterial infection and in hypersecretory diseases of the airway. The volume concludes with a discussion of the therapeutic aspects of the topic, both in terms of the possible approaches to the treatment of mucus hypersecretion and the interaction of these drugs with airway mucus. Written by leading experts in the field, each contribution provides a comprehensive review of its particular subject. Reflecting the latest advances in this important area of respiratory research, this volume will be of great interest to scientists and clinicians working in the field of airway secretions and related areas.
Accompanying CD-ROM contains ... "the complete text and illustrations ... in fully searchable PDF files."--Page 4 of cover.
Both acute and chronic cough are responsible for a significant number of ambulatory medical visits annually. The recent comprehensive understanding that “cough is a reflection of underlying disease pays tribute to the multifactorial causes, as well recognition of the respiratory and upper digestive tract as a “physiologic unit. This publication highlights the advances made in managing cough and brings these to otolaryngology practitioners in a concise forum, as well as presenting issues of special interest to laryngologists such as paradoxical vocal fold motion, disordered breathing, irritable larynx, evolution of the vagus as a protective circuit, the importance of cough in deglutition, and surgical interventions. Some of the topics include: The cough reflex, sensory receptors, and neurogenic mediators; Mucus and mucins; Cough and Swallowing dysfunction; Cough due to asthma, cough-variant asthma, and nonasthmatic eosinophilic bronchitis; Occupational, environmental, and irritant induced cough; Pharmacologic management; Unexplained cough; Cough in the pediatric population; and Rhinogenic laryngitis, cough and the unified airway; among others.
Although the potential for immunomodulation has been recognized for many years there has been an explosion of data in this field with relevance especially to the treatment of chronic airway diseases. Most of the work in this field has been conducted by Japanese investigators but in the last decade there has been a body of work outside of Japan that supports and enhances these findings. The book covers basic research like effects on bacteria, anti-inflammatory and mucoregulatory effects, but also clinical results with up-to-date information for the use of such medications to potentially treat diseases as diverse as chronic airway diseases, arthritis, inflammatory bowel disease, and cancer. The volume is intended for pulmonary physicians, researchers in inflammation research, and pharmaceutical companies interested in the development of such agents. It provides background information for the clinician as well as in depth exploration of cutting edge science.