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This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.
Springfield Township, Montgomery County, adjoins the city of Philadelphia on its northern border. The township's six-plus square miles, originally established as "Penn's Manor of Springfield," was a gift from William Penn to his wife, Gulielma Maria Springett, c. 1681. This historic township was home to a major stagecoach line and its associated taverns and inns, considerable activity during the Revolutionary War, summertime residences of Philadelphia's wealthy, and subsequent post-World War II development as a burgeoning community just over the Philadelphia border. Springfield Township's rich history is pictorially represented with a number of previously unpublished photographs from the township historical societ, and wonderful private collections. In these pages, travel through the early colonial and farming settlements of the township's original settlers, the turbulence of the Revolutionary War, the arrival of the iron horse, the excitement of White City Amusement Park, the rise and fall of the great mansions and estates, and the explosion of new development as city residents and businesses moved out to the suburbs.
That part of Philadelphia known today as Chestnut Hill, & in the early 18th century as "the hindermost part" or the "back part" of Germantown Township, includes within its boundaries the divisions of Sommerhausen & Crefeld, which formed the northernmost section of the original German township as laid out in 1684. It was 20 years or more after the first settlement in the lower part of the township before permanent improvements were established in Sommerhausen & Crefeld. This local history includes numerous mentions of individuals, families & events in this community during the 18th century. Here is a genealogical sketch of the Michael Schutz family of Chestnut Hill using the entire community as backdrop.
Describes the museum's collection of antique instruments, traces the history of technological developments in their manufacture, and looks at music's changing role in American society.
Originally published in the mid-19th century, this book provides a richly detailed history of Virginia from colonial times up through the antebellum period. Written by a prominent Virginia clergyman and historian, this book is an essential resource for anyone interested in the history of the Old Dominion. This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.