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The most feared attribute of the human pathogen Vibrio cholerae is its ability to cause outbreaks that spread like wildfire, completely overwhelming public health systems and causing widespread suffering and death. This volume starts with a description of the contrasting patterns of outbreaks caused by the classical and El Tor biotypes of V. cholerae. Subsequent chapters examine cholera outbreaks in detail, including possible sources of infection and molecular epidemiology on three different continents, the emergence of new clones through the bactericidal selection process of lytic cholera phages, the circulation and transmission of clones of the pathogen during outbreaks and novel approaches to modeling cholera outbreaks. A further contribution deals with the application of the genomic sciences to trace the spread of cholera epidemics and how this information can be used to control cholera outbreaks. The book closes with an analysis of the potential use of killed oral cholera vaccines to stop the spread of cholera outbreaks.
Cholera is a dangerous and frightening disease that can kill within hours. Chris Hamlin not only tells how the bacterial cause of cholera was discovered, but describes the experience of different countries, some of which continue to struggle with the disease today. Cholera is part of the Oxford series, Biographies of Diseases.
Reveals how the crisis of Zimbabwe's cholera outbreak of 2008-9 had profound implications for political institutions and citizenship.
"Explores the history and impact of cholera"--Provided by publisher.
The fourth cholera pandemic of the 19th century began in the Ganges Delta of the Bengal region and traveled with Muslim pilgrims to Mecca. In its first year, the epidemic claimed 30,000 of 90,000 pilgrims. Cholera spread throughout the Middle East and was carried to Russia, Europe, Africa and North America, in each case spreading via travelers from port cities and along inland waterways. The pandemic reached Northern Africa in 1865 and spread to sub-Saharan Africa, killing 70,000 in Zanzibar in 186970. Cholera claimed 90,000 lives in Russia in 1866. The epidemic of cholera that spread with the Austro-Prussian War (1866) is estimated to have taken 165,000 lives in the Austrian Empire, including 30,000 each in Hungary and Belgium, and 20,000 in the Netherlands. In June 1866, a localized epidemic in the East End of London claimed 5,596 lives, just as the city was completing construction of its major sewage and water treatment systems; the East End section was not quite complete. It was also caused by the city's overcrowding in the East End, which helped the disease to spread more quickly in the area. Epidemiologist William Farr identified the East London Water Company as the source of the contamination. Farr made use of prior work by John Snow and others, pointing to contaminated drinking water as the likely cause of cholera in an 1854 outbreak. In the same year, the use of contaminated canal water in local water works caused a minor outbreak at Ystalyfera in South Wales. Workers associated with the company, and their families, were most affected, and 119 died. In 1867, Italy lost 113,000 to cholera, and 80,000 died of the disease in Algeria. Outbreaks in North America in the 1870s killed some 50,000 Americans as cholera spread from New Orleans via passengers along the Mississippi River and to ports on its tributaries.
Recounts the history and effects of cholera outbreaks, describes how the disease spreads, and offers information about treatments and threats in the modern world.
Researchers have estimated that there are up to 4 million cases and 143,000 deaths worldwide due to Cholera. Author Diane Yancey provides your readers with a fascinating study of this disease. Readers will learn about Cholera in early times, and how it is detected now. They will learn how it is treated and prevented, and hear personal stories from sufferers.
*Includes pictures *Includes excerpts of contemporary accounts *Includes a bibliography for further reading Plague and pestilence have both fascinated and terrified humanity from the very beginning. Societies and individuals have struggled to make sense of them, and more importantly they've often struggled to avoid them. Before the scientific age, people had no knowledge of the microbiological agents - unseen bacteria and viruses - which afflicted them, and thus the maladies were often ascribed to wrathful supernatural forces. Even when advances in knowledge posited natural causes for epidemics and pandemics, medicine struggled to deal with them, and for hundreds of years religion continued to work hand-in-hand with medicine. Inevitably, that meant physicians tried a variety of practices to cure the sick, and many of them seem quite odd by modern standards. By the time Rome was on the rise, physicians understood that contagions arose and spread, but according to Galen, Hippocrates, and other Greco-Roman authorities, pestilence was caused by miasma, foul air produced by the decomposition of organic matter. Though modern scientists have since been able to disprove this, on the face of it there was some logic to the idea. Physicians and philosophers (they were very often the same, Galen being an example) noticed that disease arose in areas of poor sanitation, where filth and rotting matter was prevalent and not disposed of, and the basic measures to prevent disease was obvious to them. In the case of cholera, once among the most dreaded diseases, a breakthrough in Victorian England occurred in the mid-19th century during one of several epidemics to assault the island. In that instance, an unassuming physician named John Snow was able to trace the environmental component in which cholera was carried. He accomplished this in large part through a painstaking map cross-referencing location and specific cases of infection within a small area of London. Eventually, he narrowed the source down to a single manual water pump in the midst of the poverty-stricken neighborhood of Soho. An extensive early education provided by the first outbreak sent him on a contrarian's path in analyzing the dreaded disease. He was not blessed with the pedigree of an aristocratic family or the attendant gifts required for a young man of social substance to seek a high-level formal education. Nevertheless, he rose to be recognized not only as the world's leading anesthetist, but also as the practitioner who proved that the cholera outbreaks in Britain were the result of polluted water. Today, he is addressed as the "Father of Epidemiology," defined by Webster as a "medical science that deals with the incidence, distribution, and control of disease in a population." At the time, however, in the face of resistance launched by more powerful and pedigreed members of the medical profession, Snow was rewarded with criticism for not successfully revealing the entirety of the disease's inner mechanics. It was only over the course of several decades that Snow was able to persuade the medical community at large of the disease's source, and the British successfully established policies that helped prevent future outbreaks. Ironically, Snow eventually gained membership in Britain's high circle of elite medical practitioners, but it was not his work on cholera that initially propelled him to global fame. Ultimately, it was his pioneering work in the new field of anesthesiology, largely unknown to Britain, that earned the applause of contemporaries. John Snow and the Cholera Epidemic of 1854: The History of the Outbreak and Its Impact on Public Health Measures examines the deadly outbreak and Snow's groundbreaking findings. Along with pictures depicting important people, places, and events, you will learn about the cholera outbreak like never before.
This book combines evidence from natural and social sciences to examine the impact on Africa of seven cholera pandemics since 1817, particularly the current impact of cholera on such major countries as Senegal, Angola, Mozambique, Congo, Zimbabwe and South Africa. Myron Echenberg highlights the irony that this once-terrible scourge, having receded from most of the globe, now kills thousands of Africans annually - Africa now accounts for more than 90 percent of the world's cases and deaths - and leaves many more with severe developmental impairment. Responsibility for the suffering caused is shared by Western lending and health institutions and by often venal and incompetent African leadership. If the threat of this old scourge is addressed with more urgency, great progress in the public health of Africans can be achieved.
This is the first extended study of cholera in modern Italy, setting Naples in a comparative international framework.