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THE INSTANT NEW YORK TIMES AND WALL STREET JOURNAL BESTSELLER The capstone book in a trilogy from the New York Times bestselling author of How to Lead and The American Story and host of Bloomberg TV’s The David Rubenstein Show—American icons and historians on the ever-evolving American experiment, featuring Ken Burns, Madeleine Albright, Wynton Marsalis, Billie Jean King, Henry Louis Gates Jr., and many more. In this lively collection of conversations—the third in a series from David Rubenstein—some of our nations’ greatest minds explore the inspiring story of America as a grand experiment in democracy, culture, innovation, and ideas. -Jill Lepore on the promise of America -Madeleine Albright on the American immigrant -Ken Burns on war -Henry Louis Gates Jr. on reconstruction -Elaine Weiss on suffrage -John Meacham on civil rights -Walter Isaacson on innovation -David McCullough on the Wright Brothers -John Barry on pandemics and public health -Wynton Marsalis on music -Billie Jean King on sports -Rita Moreno on film Exploring the diverse make-up of our country’s DNA through interviews with Pulitzer Prize–winning historians, diplomats, music legends, and sports giants, The American Experiment captures the dynamic arc of a young country reinventing itself in real-time. Through these enlightening conversations, the American spirit comes alive, revealing the setbacks, suffering, invention, ingenuity, and social movements that continue to shape our vision of what America is—and what it can be.
In recent decades, advances in biomedical research have helped save or lengthen the lives of children around the world. With improved therapies, child and adolescent mortality rates have decreased significantly in the last half century. Despite these advances, pediatricians and others argue that children have not shared equally with adults in biomedical advances. Even though we want children to benefit from the dramatic and accelerating rate of progress in medical care that has been fueled by scientific research, we do not want to place children at risk of being harmed by participating in clinical studies. Ethical Conduct of Clinical Research Involving Children considers the necessities and challenges of this type of research and reviews the ethical and legal standards for conducting it. It also considers problems with the interpretation and application of these standards and conduct, concluding that while children should not be excluded from potentially beneficial clinical studies, some research that is ethically permissible for adults is not acceptable for children, who usually do not have the legal capacity or maturity to make informed decisions about research participation. The book looks at the need for appropriate pediatric expertise at all stages of the design, review, and conduct of a research project to effectively implement policies to protect children. It argues persuasively that a robust system for protecting human research participants in general is a necessary foundation for protecting child research participants in particular.
The Political Theory of a Compound Republic presents the essential logic of James Madison and Alexander Hamilton's design of limited, distributed, constitutional authority proposed inThe Federalist. Two revised and expanded ensuing chapters show how the idea of constitutional choice has been employed since the adoption of the 1789 Constitution of the United States. A new concluding chapter questions commonly accepted beliefs about sovereign nation-states and considers governance from the perspective of twenty-first century 'citizen-sovereigns.'
In nineteenth-century Britain, the effects of democracy in America were seen to spread from Congress all the way down to the personal habits of its citizens. Bringing together political theorists, historians, and literary scholars, this volume explores the idea of American democracy in nineteenth-century Britain. The essays span the period from Independence to the First World War and trace an intellectual history of Anglo-American relations during that period. Leading scholars trace the hopes and fears inspired by the American model of democracy in the works of commentators, including Thomas Paine, Mary Wollstonecraft, Alexis de Tocqueville, Charles Dickens, John Stuart Mill, Richard Cobden, Charles Dilke, Matthew Arnold, Henry James and W. T. Stead. By examining the context of debates about American democracy and notions of ‘culture’, citizenship, and race, the collection sheds fresh light on well-documented moments of British political history, such as the Reform Acts, the Abolition of Slavery Act, and the Anti-Corn Law agitation. The volume also explores the ways in which British Liberalism was shaped by the American example and draws attention to the importance of print culture in furthering radical political dialogue between the two nations. As the comprehensive introduction makes clear, this collection makes an important contribution to transatlantic studies and our growing sense of a nineteenth-century modernity shaped by an Atlantic exchange. It is an essential reference point for all interested in the history of the idea of democracy, its political evolution, and its perceived cultural consequences.

The Belmont Report

United States. National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research

Published: 1978

Total Pages: 614


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#1 NEW YORK TIMES BESTSELLER • “The story of modern medicine and bioethics—and, indeed, race relations—is refracted beautifully, and movingly.”—Entertainment Weekly NOW A MAJOR MOTION PICTURE FROM HBO® STARRING OPRAH WINFREY AND ROSE BYRNE • ONE OF THE “MOST INFLUENTIAL” (CNN), “DEFINING” (LITHUB), AND “BEST” (THE PHILADELPHIA INQUIRER) BOOKS OF THE DECADE • ONE OF ESSENCE’S 50 MOST IMPACTFUL BLACK BOOKS OF THE PAST 50 YEARS • WINNER OF THE CHICAGO TRIBUNE HEARTLAND PRIZE FOR NONFICTION NAMED ONE OF THE BEST BOOKS OF THE YEAR BY The New York Times Book Review • Entertainment Weekly • O: The Oprah Magazine • NPR • Financial Times • New York • Independent (U.K.) • Times (U.K.) • Publishers Weekly • Library Journal • Kirkus Reviews • Booklist • Globe and Mail Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor Southern tobacco farmer who worked the same land as her slave ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine: The first “immortal” human cells grown in culture, which are still alive today, though she has been dead for more than sixty years. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions. Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave. Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family—past and present—is inextricably connected to the dark history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of. Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah. Deborah was consumed with questions: Had scientists cloned her mother? Had they killed her to harvest her cells? And if her mother was so important to medicine, why couldn’t her children afford health insurance? Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.
A scientific study of the political and economic factors influencing democratic decision making
Whether we're buying a pair of jeans, ordering a cup of coffee, selecting a long-distance carrier, applying to college, choosing a doctor, or setting up a 401(k), everyday decisions—both big and small—have become increasingly complex due to the overwhelming abundance of choice with which we are presented. As Americans, we assume that more choice means better options and greater satisfaction. But beware of excessive choice: choice overload can make you question the decisions you make before you even make them, it can set you up for unrealistically high expectations, and it can make you blame yourself for any and all failures. In the long run, this can lead to decision-making paralysis, anxiety, and perpetual stress. And, in a culture that tells us that there is no excuse for falling short of perfection when your options are limitless, too much choice can lead to clinical depression. In The Paradox of Choice, Barry Schwartz explains at what point choice—the hallmark of individual freedom and self-determination that we so cherish—becomes detrimental to our psychological and emotional well-being. In accessible, engaging, and anecdotal prose, Schwartz shows how the dramatic explosion in choice—from the mundane to the profound challenges of balancing career, family, and individual needs—has paradoxically become a problem instead of a solution. Schwartz also shows how our obsession with choice encourages us to seek that which makes us feel worse. By synthesizing current research in the social sciences, Schwartz makes the counter intuitive case that eliminating choices can greatly reduce the stress, anxiety, and busyness of our lives. He offers eleven practical steps on how to limit choices to a manageable number, have the discipline to focus on those that are important and ignore the rest, and ultimately derive greater satisfaction from the choices you have to make.