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Dr. Gànti has introduced Chemoton Theory to explain the origin of life. Theoretical Foundations of Fluid Machineries is a discussion of the theoretical foundations of fluid automata. It introduces quantitative methods - cycle stoichiometry and stoichiokinetics - in order to describe fluid automata with the methods of algebra, as well as their construction, starting from elementary chemical reactions up to the complex, program-directed, proliferating fluid automata, the chemotons. Chemoton Theory outlines the development of a theoretical biology, based on exact quantitative considerations and the consequences of its application on biotechnology and on the artificial synthesis of living systems.
Beginning with a new essay, "Levels of Life and Death," Tibor Gánti develops three general arguments about the nature of life. In "The Nature of the Living State," Professor Gánti answers Francis Crick's puzzles about "life itself," offering a set of reflections on the parameters of the problems to be solved in origins of life research and, more broadly, in the search for principles governing the living state in general. "The Principle of Life" describes in accessible language Gánti's chief insight about the organization of living systems-his theory of the "chemoton," or chemical automaton. The simplest chemoton model of the living state consists of three chemically coupled subsystems: an autocatalytic metabolism, a genetic molecule and a membrane. Gánti offers a fresh approach to the ancient problem of "life criteria," articulating a basic philosophy of the units of life applicable to the deepest theoretical considerations of genetics, chemical synthesis, evolutionary biology and the requirements of an "exact theoretical biology." New essays by Eörs Szathmáry and James Griesemer on the biological and philosophical significance of Gánti's work of thirty years indicate not only the enduring theoretical significance, but also the continuing relevance and heuristic power of Gánti's insights. New endnotes by Szathmáry and Griesemer bring this legacy into dialogue with current thought in biology and philosophy. Gánti's chemoton model reveals the fundamental importance of chemistry for biology and philosophy. Gánti's technical innovation - cycle stoichiometry - at once captures the fundamental fact that biological systems are organized in cycles and at the same time offers a way to understand what it is to think chemically. Perhaps most fundamentally, Gánti's chemoton model avoids dualistic thinking enforced by the dichotomies of modern biology: germ and soma, gene and character, genotype and phenotype.
The social sciences have sophisticated models of choice and equilibrium but little understanding of the emergence of novelty. Where do new alternatives, new organizational forms, and new types of people come from? Combining biochemical insights about the origin of life with innovative and historically oriented social network analyses, John Padgett and Walter Powell develop a theory about the emergence of organizational, market, and biographical novelty from the coevolution of multiple social networks. In the short run, they argue, actors make relations, but in the long run, they argue, actors make actors. Organizational novelty arises from spillover across intertwined networks, which tips reproducing biographical and production flows. This theory is developed through formal deductive modeling and through a wide range of careful and original historical case studies, ranging from early capitalism and state formation, to the transformation of communism, to the emergence of contemporary biotechnology and Silicon Vally. -- from back cover.
Introduces a broad range of scientific and philosophical issues about life through the original historical and contemporary sources.
Proceedings from the ninth International Conference on Artificial Life; papers by scientists of many disciplines focusing on the principles of organization and applications of complex, life-like systems. Artificial Life is an interdisciplinary effort to investigate the fundamental properties of living systems through the simulation and synthesis of life-like processes. The young field brings a powerful set of tools to the study of how high-level behavior can arise in systems governed by simple rules of interaction. Some of the fundamental questions include: What are the principles of evolution, learning, and growth that can be understood well enough to simulate as an information process? Can robots be built faster and more cheaply by mimicking biology than by the product design process used for automobiles and airplanes? How can we unify theories from dynamical systems, game theory, evolution, computing, geophysics, and cognition? The field has contributed fundamentally to our understanding of life itself through computer models, and has led to novel solutions to complex real-world problems across high technology and human society. This elite biennial meeting has grown from a small workshop in Santa Fe to a major international conference. This ninth volume of the proceedings of the international A-life conference reflects the growing quality and impact of this interdisciplinary scientific community.
The two-volume set LNAI 5777 and LNAI 5778 constitutes the thoroughly refereed post-conference proceedings of the 10th European Conference, ECAl 2009, held in Budapest, Hungary, in September 2009. The 141 revised full papers presented were carefully reviewed and selected from161 submissions. The papers are organized in topical sections on evolutionary developmental biology and hardware, evolutionary robotics, protocells and prebiotic chemistry, systems biology, artificial chemistry and neuroscience, group selection, ecosystems and evolution, algorithms and evolutionary computation, philosophy and arts, optimization, action, and agent connectivity, and swarm intelligence.
How did life begin on the Earth? The units of life are cells, which can be defined as bounded systems of molecules that capture energy and nutrients from the environment -- systems that expand, reproduce, and evolve over time, often into more complex systems. This book is the proceedings of a unique meeting, sponsored by NATO and held in Maratea, Italy, that brought together for the first time an international group of investigators who share an interest in how molecules self-assemble into supramolecular structures, and how those structures may have contributed to the origin of life. The book is written at a moderately technical level, appropriate for use by researchers and by students in upper-level undergraduate and graduate courses in biochemistry and molecular biology. The overall interest of its subject matter provides an excellent introduction for students who wish to understand how the foundational knowledge of chemistry and physics can be applied to one of the most fundamental questions now facing the scientific community. The editors are pioneers in defining what we mean by the living state, particularly the manner in which simple molecular systems can assume complex associations and functions, including the ability to reproduce. Each chapter of the book presents an up-to-date report of highly significant research. Two of the authors received medals from the National Academy of Science USA in 1994, and other research reported in the book has been featured in internationally recognized journals such Scientific American, Time, and Discover.
The first comprehensive general resource on state-of-the-art protocell research, describing current approaches to making new forms of life from scratch in the laboratory. Protocells offers a comprehensive resource on current attempts to create simple forms of life from scratch in the laboratory. These minimal versions of cells, known as protocells, are entities with lifelike properties created from nonliving materials, and the book provides in-depth investigations of processes at the interface between nonliving and living matter. Chapters by experts in the field put this state-of-the-art research in the context of theory, laboratory work, and computer simulations on the components and properties of protocells. The book also provides perspectives on research in related areas and such broader societal issues as commercial applications and ethical considerations. The book covers all major scientific approaches to creating minimal life, both in the laboratory and in simulation. It emphasizes the bottom-up view of physicists, chemists, and material scientists but also includes the molecular biologists' top-down approach and the origin-of-life perspective. The capacity to engineer living technology could have an enormous socioeconomic impact and could bring both good and ill. Protocells promises to be the essential reference for research on bottom-up assembly of life and living technology for years to come. It is written to be both resource and inspiration for scientists working in this exciting and important field and a definitive text for the interested layman.
Devoted to exploring questions about the origin and evolution of life in our Universe, this highly interdisciplinary book brings together a broad array of scientists. Thirty chapters assembled in eight major sections convey the knowledge accumulated and the richness of the debates generated by this challenging theme. The text explores the latest research on the conditions and processes that led to the emergence of life on Earth and, by extension, perhaps on other planetary bodies. Diverse sources of knowledge are integrated, from astronomical and geophysical data, to the role of water, the origin of minimal life properties and the oldest traces of biological activity on our planet. This text will not only appeal to graduate students but to the large body of scientists interested in the challenges presented by the origin of life, its evolution, and its possible existence beyond Earth.
Systematically explores the early origins and basic definition of life. Investigates the major theories of the origins of life in light of modern research with the aim of distinguishing between the necessary and the optional and between deterministic and random influences in the emergence of what we call ‘life.’ Treats and views life as a cosmic phenomenon whose emergence and driving force should be viewed independently from its Earth-bound natural history. Synthesizes all the fundamental life-related developments in a comprehensive scenario, and makes the argument that understanding life in its broadest context requires a material-independent perspective that identifies its essential fingerprints