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Conceptual models of how pain is created influence medical practice, neuroscientific research, and philosophical ideas about pain and other neurological functions. Given the broad scope of pain experiences, realistic models of pain neurobiology must consider the correlation between pain and tissue damage and how it is strongly affected by neurological disease, emotionally compelling circumstances, and by complex cognitive processes. Recent discoveries have made it clear that both sensory and affective systems are strongly modulated by activity in other sensory pathways and by affective and cognitive processes originating in the brain. As a result, pain should then be conceived as emerging from the conjoint activity of both sensory and affective neural systems, each becoming a target for pain treatment. Historically, pain has been conceived as emerging either from an undefined pattern of neural activity or from anatomically and physiologically unique structures in the nervous system. Observations made during the early and mid- 20th century showed that pain and pain-like behaviors normally require not only sensory detectors of noxious events (called nociceptors) but also brain affective (hedonic) mechanisms that generate emotional experience and expression. In Chasing Pain, pain specialists and neuroscientists will find a thoughtful discussion of the neuroscientific and clinical evidence that has led to contemporary concepts of pain neurobiology and how pain might emerge from neuronal activity. Written in a concise and annotated format, Doctor Kenneth Casey reveals that while contemporary research has greatly enriched our model of pain neurobiology, several important and therapeutically challenging clinical conditions remain poorly understood.
Conceptual models of how pain is created influence medical practice, neuroscientific research, and philosophical ideas about pain and other neurological functions. Given the broad scope of pain experiences, realistic models of pain neurobiology must consider the correlation between pain and tissue damage and how it is strongly affected by neurological disease, emotionally compelling circumstances, and by complex cognitive processes. Recent discoveries have made it clear that both sensory and affective systems are strongly modulated by activity in other sensory pathways and by affective and cognitive processes originating in the brain. As a result, pain should then be conceived as emerging from the conjoint activity of both sensory and affective neural systems, each becoming a target for pain treatment. Historically, pain has been conceived as emerging either from an undefined pattern of neural activity or from anatomically and physiologically unique structures in the nervous system. Observations made during the early and mid- 20th century showed that pain and pain-like behaviors normally require not only sensory detectors of noxious events (called nociceptors) but also brain affective (hedonic) mechanisms that generate emotional experience and expression. In Chasing Pain, pain specialists and neuroscientists will find a thoughtful discussion of the neuroscientific and clinical evidence that has led to contemporary concepts of pain neurobiology and how pain might emerge from neuronal activity. Written in a concise and annotated format, Doctor Kenneth Casey reveals that while contemporary research has greatly enriched our model of pain neurobiology, several important and therapeutically challenging clinical conditions remain poorly understood.
"Pain has always been a problem for Western Society, but not the same kind of problem. Until about 1500, pain was primarily understood as a religious problem. Pain and suffering challenged the truth of religious belief and the legitimacy of the Church: How could a just, merciful, and all-powerful God allow so much pain and suffering in the world? As our society became more secular over the next 300 years, pain came to be understood primarily as a social problem. This modernizing society aimed to create the best environment for human flourishing: How might human society be designed and regulated to reduce the pain and suffering of everyone to the minimum possible? At least since 1900, we have separated pain as a medical problem from the remainder of human suffering. We have aimed to reduce this problem to a minimum through medical treatment. This quest has led us to our opioid epidemic. To fully comprehend the limitations of this medical interpretation, we must appreciate how the medical explanation of pain grew out of earlier religious and social interpretations of pain"--
One in three people will develop some kind of cancer in their lifetime. The overall cancer incidence has increased by 25% since 1975. Anaesthetic involvement in hospital interactions has been estimated at around 75%, and so anaesthetists are likely to have major input into the care of the cancer patient. This input may start with the preoperative assessment, but often extends to the intensive care unit and the management of both acute and chronic disease, or procedural related pain. This book is comprised of five main sections dealing with cancer, anaesthesia for cancer surgery, intensive care, pain management and supportive and palliative care. The chapters are authored by acknowledged specialists in their field of cancer patient management. The anaesthesia section discusses not just major surgery but includes the specific and subtle differences that exist in the diverse types of specialist cancer surgery. The pain section deals with the current status of several specific cancer pain problems with contemporary evidence and recent developments in management. This book also introduces novel ways of looking at conventional treatments such as the genetic aspects of opioid use. For a complete understanding of the cancer patient, other aspects of care are also considered, including psychological care and complementary medicines.
The Encyclopedia of the Neurological Sciences, Second Edition, Four Volume Set develops from the first edition, covering all areas of neurological sciences through over 1000 entries focused on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. The contributing authors represent all aspects of neurology from many viewpoints and disciplines to provide a complete overview of the field. Entries are designed to be understandable without detailed background knowledge in the subject matter, and cross-referencing and suggested further reading lead the reader from a basic knowledge of the subject to more advanced understanding. The easy-to-use 'encyclopedic-dictionary' format of the Encyclopedia of the Neurological Sciences, Second Edition features alphabetic entries, extensive cross-referencing, and a thorough index for quick reference. The wealth of information provided by these four volumes makes this reference work a trusted source of valuable information for a wide range of researchers, from undergraduate students to academic researchers. Provides comprehensive coverage of the field of neurological science in over 1,000 entries in 4 volumes "Encyclopedic-dictionary" format provides for concise, readable entries and easy searching Presents complete, up-to-date information on 32 separate areas of neurology Entries are supplemented with extensive cross-referencing, useful references to primary research articles, and an extensive index
A must-have book for any health professional who treats patients with headache disorders, Refractory Migraine is written by international experts from the world's top headache centers. It describes how they approach the treatment of migraine patients who continue to suffer despite appropriate medical treatment. First, it highlights current ideas about the definition and characterization of refractory migraine, and reviews underlying causes and contributing factors. Then, individual chapters cover every important aspect of migraine treatment with the focus entirely on refractory forms of the disorder. Its many features include detailed algorithms for outpatient and inpatient withdrawal from overused medications, innovative drug therapy and nonpharmacological treatments, a list of questions to ask before deciding to try hormonal therapies, and detailed descriptions of how to recognize and interact with patients who have challenging personality disorders or concomitant psychiatric problems. We're confident you'll often turn to this book for advice about challenges in migraine management. When you do, the bulleted lists and boxes that highlight and condense the main messages of each chapter put the information you need at your fingertips. If you treat patients with migraine, you will recognize many of the challenging situations and topics covered in this book - and you will be encouraged by the innovative and resourceful therapeutic strategies suggested by seasoned headache doctors with a wealth of clinical experience. Readable, comprehensive and up to date, this book gives you access to ingenious treatment approaches developed and refined in specialty headache clinics that regularly - and successfully - treat patients with refractory headache problems. When you meet the next migraine patient who says "I've tried it all, and nothing works", you will know where to go for practical advice about what to do next.
INSTANT NEW YORK TIMES and LOS ANGELES TIMES BESTSELLER “Brilliant . . . riveting, scary, cogent, and cleverly argued.”—Beth Macy, author of Dopesick, as heard on Fresh Air This book is about pleasure. It’s also about pain. Most important, it’s about how to find the delicate balance between the two, and why now more than ever finding balance is essential. We’re living in a time of unprecedented access to high-reward, high-dopamine stimuli: drugs, food, news, gambling, shopping, gaming, texting, sexting, Facebooking, Instagramming, YouTubing, tweeting . . . The increased numbers, variety, and potency is staggering. The smartphone is the modern-day hypodermic needle, delivering digital dopamine 24/7 for a wired generation. As such we’ve all become vulnerable to compulsive overconsumption. In Dopamine Nation, Dr. Anna Lembke, psychiatrist and author, explores the exciting new scientific discoveries that explain why the relentless pursuit of pleasure leads to pain . . . and what to do about it. Condensing complex neuroscience into easy-to-understand metaphors, Lembke illustrates how finding contentment and connectedness means keeping dopamine in check. The lived experiences of her patients are the gripping fabric of her narrative. Their riveting stories of suffering and redemption give us all hope for managing our consumption and transforming our lives. In essence, Dopamine Nation shows that the secret to finding balance is combining the science of desire with the wisdom of recovery.
Pain: Clinical Manual advocates an interdiciplinary approach to the care of patients with often under-treated pain. This book makes the application to scientific knowledge to the development of practical tools and guidelines for the care of patients in all clinical settings and all age groups. * Provides ready-to-use forms and recommendations for pain care committees to assist health care facilities to prepare for JCAHO inspections. * Includes two FREE pocket-size, laminated cards: equianalgesic charts to assist clinicians with dose calculations when changing routes of administration or analgesics, and dosing guides to commonly used adjuvants and nonopioids. * Includes FREE access to Mosby's PAIN WEBSITE. * The most clinically useful book ever published on pain, written by authorities who helped establish the pain management movement. * Includes 11 new chapters and five expanded and updated chapters to provide the most accurate, up-to-date, and comprehensive pain management information. * Includes icons to alert the reader to important, need-to-know information, such as pediatric content, patient examples, and reproducible material. * Features over 200 boxes and tables to help quickly locate key information and apply complex concepts at the bedside. * Presents a unique, multidisciplinary perspective. * Provides ready-to-use, practical, proven, and reproducible tools, pain assessment and documentation forms, and guides to analgesic use. * Contains patient information handouts on analgesics and nondrug methods of pain relief to educate the patient/family/caregiver about the patient's specific pain management. * Includes reproducible key policies, procedures, and protocols to assist the clinician in implementing patient focused interdisciplinary pain management. * Presents pharmacology content in four chapters - the three analgesic groups and an overview of how to combine them - to provide a readily understandable reference and practical resource. * Includes quick guides with illustrations of selected pain problems, such as pain related to sickle cell disease, peripheral neuropathy, and fibromyalgia. * Contains pain rating scales in over 20 languages to enhance patient/clinician communication in culturally diverse populations.
Some investigators have argued that emotions, especially animal emotions, are illusory concepts outside the realm of scientific inquiry. However, with advances in neurobiology and neuroscience, researchers are demonstrating that this position is wrong as they move closer to a lasting understanding of the biology and psychology of emotion. In Affective Neuroscience, Jaak Panksepp provides the most up-to-date information about the brain-operating systems that organize the fundamental emotional tendencies of all mammals. Presenting complex material in a readable manner, the book offers a comprehensive summary of the fundamental neural sources of human and animal feelings, as well as a conceptual framework for studying emotional systems of the brain. Panksepp approaches emotions from the perspective of basic emotion theory but does not fail to address the complex issues raised by constructionist approaches. These issues include relations to human consciousness and the psychiatric implications of this knowledge. The book includes chapters on sleep and arousal, pleasure and fear systems, the sources of rage and anger, and the neural control of sexuality, as well as the more subtle emotions related to maternal care, social loss, and playfulness. Representing a synthetic integration of vast amounts of neurobehavioral knowledge, including relevant neuroanatomy, neurophysiology, and neurochemistry, this book will be one of the most important contributions to understanding the biology of emotions since Darwins The Expression of the Emotions in Man and Animals
Sir William Richard Gowers was one of the pre-eminent clinical neurologists of the nineteenth century. Co-authored by one of Dr Gowers' descendents and two leading neurologists, this book is the definitive reference work on the life of one of the founding fathers of neurology.