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If you’re looking to deepen your understanding of kidney disease, look no further than Heptinstall’s Pathology of the Kidney, 7th Edition. Authored by the world’s most accomplished renal pathologists, this image-rich text conveys the intricacies and comprehensiveness of renal disease, offering powerful diagnostic and treatment recommendations from decades of clinical research. Stay up to date on the cutting edge of kidney research and treatment and offer your patients the best therapeutic options and preventative measures available today.
these analyses it became clear that the MHC class I molecule com prised a distinct groove on the external side of the molecule. The sides of the groove are formed by the a-helical structures of the a and a 1 2 domains and a floor which is formed by 8 anti-parallel 13 strands. The various polymorphic residues, as determined from DNA sequence analysis, are localized within these a-helices and 13-plated sheets within the groove. More importantly, these analyses also revealed the presence of elec tron-dense material in the groove. This material was subsequently iden 568 10 tified as a linear peptide of 8-10 amino acids long. • •- High resolu tion crystallographic analyses of the class I MHC structure have revealed the existence of so-called pockets within the grooves of the MHC class I molecules. These pockets designated A-F, exhibited allele-specificity and are directly involved in the binding of the peptide, primarily through interaction with the dominant anchor residues as found in MHC class I associated pep tides. 6,7,9,11 The class II MHC antigens consist on the cell surface of a 34 kD a chain non-covalently associated with a 28 kD 13 chain. With the excep tion of the DR a-chain, all other MHC class II a and 13 chains are poly morphic.
Proceedings of the 25th Conference on Transplantation and Clinical Immunology 24--26 May 1993
Critical Analysis of Monoclonal Antibody Therapy in Transplantation provides a critical analysis of monoclonal antibody therapies in transplantation. The book presents diverse approaches to monoclonal antibody therapy in transplantation and addresses some of the serious obstacles that remain both in understanding these mechanisms and in successfully applying them in clinical situations. The background and rationale for OKT3 therapy are examined and an extensive clinical experience with OKT3 induction therapy in cardiac transplantation is reviewed. The book also examines the background and rationale for the use of anti-TcR (??), anti-IL-2R, and anti-LFA-1 monoclonal antibodies in clinical transplantations. Other topics include the use of monclonal antibodies to CD4 and CD8 for the induction of adult transplantation tolerance in rodents and the possibilities for applying anti-idiotypical strategies that have proven useful in autoimmunity models to transplant recipients. Researchers and basic scientists involved in this field will find the book a fascinating and useful resource for their investigations.
With meticulous updates throughout, Kidney Transplantation remains your definitive medical resource for state-of-the-art answers on every aspect of renal transplantation. A multidisciplinary approach from internationally renowned nephrologists from around the world offers practice-applicable guidance for all members of the transplant team. With coverage encompassing applied science, surgical techniques, immunosuppressive methods, outcomes, risks, and medical considerations related to kidney transplantation, both in adults and children, you’ll have the balanced information you need to achieve the best possible outcomes. Visualize key concepts and discern nuances of renal transplantation techniques through more than 335 superb illustrations.
The Laboratory Rat, Second Edition features updated information on a variety of topics including: rat genetics and genomics, both spontaneous and induced disease; state-of-the-art technology for housing and husbandry; occupational health, and experimental models. A premier source of information on the laboratory rat that will be of interest to veterinary and medical students, senior graduate, graduate students, post-docs and researchers who utilize animals in biomedical research. - At least 50% new information than first edition - Includes topics on rat genetics and genomics, occupational health, and experimental models - The premier source of information on the laboratory rat
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Long-term Care of Kidney Transplant Patients provides all aspects of long-term care of kidney transplant patients. Many of the chapters highlight unmet needs relevant to certain post-transplant events that influence survival. Chapters provide clinicians and researchers with opportunities to investigate and advance the science by performing studies than can alter the trajectory of specific post-transplant diseases which will improve long-term kidney survival further until we achieve "Transplant Tolerance."