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This volume provides a comprehensive and multidisciplinary overview of fibrocytes, written by the main researchers in the field. It is aimed at a broad audience of scientists and clinicians with an interest in the role of circulating fibrocytes in the etiopathogenesis of different fibrosing disorders, atherosclerosis, autoimmunity, and cancer.
Since the discovery of the circulating ?fibrocyte? in 1994 as a collagen-producing cell of the peripheral blood, the physiologic and pathologic role of this unique cell populaton has grown steadily. This pioneering new book provides the first comprehensive review of the role of fibrocytes in wound repair, granuloma formation, antigen presentation, scar formation, and various fibrosing disorders such as interstitial lung disease and nephrogenic systemic fibrosis. It also includes discussions of the recent studies on the molecular signals that influence fibrocyte migration, proliferation, and function in the context of normal physiology and pathology. The chapters are contributed by the leading researchers in the field.
The developments in molecular medicine are transforming respiratory medicine. Leading clinicians and scientists in the world have brought their knowledge and experience in their contributions to this book. Clinicians and researchers will learn about the most recent advances in a variety of lung diseases that will better enable them to understand respiratory disorders. This treatise presents state of the art essays on airways disease, neoplastic diseases, and pediatric respiratory conditions. Additionally, aspects of immune regulation, respiratory infections, acute lung injury/ARDS, pulmonary edema, functional evaluation in respiratory disorders, and a variety of other conditions are also discussed. The book will be invaluable to clinicians who keep up with the current concepts, improve their diagnostic skills, and understand potential new therapeutic applications in lung diseases, while scientists can contemplate a plethora of new research avenues for exploration.
The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments. * Each chapter considers Asthma and COPD in side-by-side contrast and comparison – not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management * Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD * Most extensive reference to primary literature on both Asthma and COPD in one source. * Easy-to-read summaries of the latest advances alongside clear illustrations
Interstitial Lung Disease, Fourth Edition is a complete publication of interstitial lung diseases and includes clinical, pathologic, radiologic, and physiologic evaluation of the patient with ILD. It provides a basic pathobiology and a complete description of individual disease entities. The book covers a wide array of disorders - sarcoidosis, asbestosis, hypersensitivity pneumonitis, drug-induced lung disease, connective tissue disease, and pulmonary vasculitis, to name but a few. This new edition also features an examination of future potential therapies for interstitial lung disease. Interstitial Lung Disease is divided into three sections. The Clinical Approach section provides the basis for recognizing the key features that allow a specific diagnosis to be achieved. The section dedicated to Basic Mechanisms emphasizes the many advances in genetics and cellular and molecular biology that have greatly expanded our understanding of the biological processes involved in the pathogenesis of the interstitial lung diseases. The third section titled Clinical Entities describes the clinical manifestations, radiologic patterns, histopathological features, and management of the specific process
The revised edition of the renowned and bestselling title is the most comprehensive single text on all aspects of biomaterials science from principles to applications. Biomaterials Science, fourth edition, provides a balanced, insightful approach to both the learning of the science and technology of biomaterials and acts as the key reference for practitioners who are involved in the applications of materials in medicine.This new edition incorporates key updates to reflect the latest relevant research in the field, particularly in the applications section, which includes the latest in topics such as nanotechnology, robotic implantation, and biomaterials utilized in cancer research detection and therapy. Other additions include regenerative engineering, 3D printing, personalized medicine and organs on a chip. Translation from the lab to commercial products is emphasized with new content dedicated to medical device development, global issues related to translation, and issues of quality assurance and reimbursement. In response to customer feedback, the new edition also features consolidation of redundant material to ensure clarity and focus. Biomaterials Science, 4th edition is an important update to the best-selling text, vital to the biomaterials' community. - The most comprehensive coverage of principles and applications of all classes of biomaterials - Edited and contributed by the best-known figures in the biomaterials field today; fully endorsed and supported by the Society for Biomaterials - Fully revised and updated to address issues of translation, nanotechnology, additive manufacturing, organs on chip, precision medicine and much more. - Online chapter exercises available for most chapters
In this state-of-the-art exploration of a hugely dynamic and fast-evolving field of research, leading researchers share their collective wisdom on the role that stem cells could play in the context of physiological stress and lung injury. The text focuses on reviewing the most relevant—and recent—ideas on using local, endogenous, and exogenous progenitor/stem cells in preventing and treating injury to the lung. The lungs are one of the most complex organs in the human body, with a mature adult lung boasting at least 40 morphologically differentiated cell lineages. Our entire blood supply passes through the lung’s alveolar units during oxygenation. This interaction with the outside world, along with the intricacies of its structure, makes the lung a highly susceptible organ that is vulnerable to numerous types of injury and infection. This means that the mechanisms of lung repair are in themselves correspondingly complex. Because of their multipotentiality, as well as the fact of the lung’s relatively rapid cell turnover, stem cells are thought to be an important alternative cell-base therapy in lung injury. Despite the controversial nature of stem cell research, there has been growing interest in both local and endogenous stem cells in the lung. This highly topical book with chapters on everything from using mesenchymal stem cells in lung repair to the effect of physical activity on the mobilization of stem and progenitor cells, represents an exciting body of work by outstanding investigators and will be required reading for those with an interest in the subject.
This book provides a comprehensive overview in our understanding of the biology and therapeutic potential of hematopoietic stem cells, and is aimed at those engaged in stem cell research: undergraduate and postgraduate science students, investigators and clinicians. Starting from fundamental principles in hematopoiesis, Advances in Hematopoietic Stem Cell Research assemble a wealth of information relevant to central mechanisms that may regulate differentiation, and expansion of hematopoietic stem cells in normal conditions and during disease.