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From a logical point of view, cell division is regulated by the environment and by the ability of the cell to respond to the environmental signals. The terminology of the cell cycle, the elaborate mathematical models, and the kinetic analyses are all convenient notations and descriptions of the behavior of populations of cells. However, they tell us very little about the fundamental molecular mechanisms that control cell proliferation. Stated in other terms, what controls cell reproduction are growth factors in the environment and genes and gene products inside the cell or at its surface. This book examines the aforementioned growth factors, the study of which has made very rapid progress in the past few years. The selection of topics has been influenced by logistic considerations, but the book, as a whole, gives a broad survey of the state of the art of this exciting field. For this, thanks are due to the contributors, who have given much time to the preparation of the manuscripts and have met the deadline with a punctuality that is uncommon among biomedical scientists. I would also like to thank Ms. NORA PERRETT and the staff of Springer-Verlag for their help in editing the manuscripts and in preparing the production of the book.
Animals and Environmental Fitness, Volume 1: Invited Lectures is a collection of papers that tackles ecological concerns. The materials of the book are organized according the main issue of their contents. The text first tackles the chemical factors of the environment, such as water and oxygen availability, ecomones, and pollutants. The other half of the book encompasses the physical factors of the environment that include light, pressure, and temperature. The text will be of great use to scientists who study the interaction between flora, fauna, and the total environment.
It has been known for some time that certain types of cells, including those in reproductive tissues, produce substances that act by autocrine and paracrine means to control cellular functions, including promotion and inhibition of cell growth. This volume is based on a symposium held under the sponsorship of the World Health Organization to review the many newly recognized growth factors controlling physiological functions of the reproductive tract. The contributions presented here offer new and expanded insights into the functioning of the reproductive tract, examining many basic physiological and molecular mechanisms with potential in the development of new approaches to fertility regulation. Promising areas for further research are identified, and new systems for in vitro study of growth factors are discussed.
Maia is the story of an idea, and its development into a working hypothesis, that provides a cybernetic interpretation of how growth is controlled. Growth at the lowest level is controlled by regulating the rate of growth. Access to the output of control mechanisms is provided by perturbing the growing organism, and then filtering out the consequences to growth rate. The output of the growth control mechanism is then accessible for interpretation and modelling. Perturbation experiments have been used to provide interpretations of hormesis, the neutralization of inhibitory load and acquired tolerance to toxic inhibition, and catch-up growth. The account begins with an introduction to cybernetics covering the regulation of growth and population increase in animals and man and describes this new approach to access the control of growth processes. This book is suitable for postgraduate students of biological cybernetics and researchers of biological growth, endocrinology, population ecology and toxicology.