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A challenging task, in the area of magnetic resonance imaging is to develop contrast enhancers with built-in antioxidant properties. Oxidative stress is considered to be involved in the onset and progression of several serious conditions such as Alzheimer’s and Parkinson’s disease, and the possibility to use cerium-contained nanoparticles to modulate such inflammatory response has gained a lot of interest lately. The rare earth element gadolinium is, due to its seven unpaired f-electrons and high symmetry of the electronic state, a powerful element for contrast enhancement in magnetic resonance imaging. Chelates based on gadolinium are the most commonly used contrast agents worldwide. When introducing external contrast agents there is always a risk that it may trigger inflammatory responses, why there is an urgent need for new, tailor-made contrast agents. Small sized cerium oxide nanoparticles have electronic structures that allows coexistence of oxidation states 3+ and 4+ of cerium, which correlates to applicable redox reactions in biomedicine. Such cerium oxide nanoparticles have recently shown to exhibit antioxidant properties both in vitro and in vivo, via the mechanisms involving enzyme mimicking activity. This PhD project is a comprehensive investigation of cerium oxide nanoparticles as scaffold materials for gadolinium integration. Gadolinium is well adopted into the crystal structure of cerium oxide, enabling the combination of diagnostic and therapeutic properties into a single nanoparticle. The main focus of this thesis project is to design cerium oxide nanoparticles with gadolinium integration. A stepwise approach was employed as follows: 1) synthesis with controlled integration of gadolinium, 2) material characterization by means of composition crystal structure, size, and size distribution and 3) surface modification for stabilization. The obtained nanoparticles exhibit remarkable antioxidant capability in vitro and in vivo. They deliver strongly enhanced contrast per gadolinium in magnetic resonance imaging, compared to commercially available contrast agents. A soft shell of dextran is introduced to encapsulate the cerium oxide nanoparticles with integrated gadolinium, which protects and stabilizes the hard core and to increases their biocompatibility. The dextran-coating is clearly shown to reduce formation of a protein corona and it improves the dispersibility of the nanoparticles in cell media. Functionalization strategies are currently being studied to endow these nanoparticles with specific tags for targeting purposes. This will enable guidance of the nanoparticles to a specific tissue, for high local magnetic resonance contrast complemented with properties for on-site reduced inflammation. In conclusion, our cerium oxide nanoparticles with integrated gadolinium, exhibit combined therapeutic and diagnostic, i.e. theragnostic capabilities. This type of nanomaterial is highly promising for applications in the field of biomedical imaging.
Cerium Oxide (CeO2): Synthesis, Properties and Applications provides an updated and comprehensive account of the research in the field of cerium oxide based materials. The book is divided into three main blocks that deal with its properties, synthesis and applications. Special attention is devoted to the growing number of applications of ceria based materials, including their usage in industrial and environmental catalysis and photocatalysis, energy production and storage, sensors, cosmetics, radioprotection, glass technology, pigments, stainless steel and toxicology. A brief historical introduction gives users background, and a final chapter addresses future perspectives and outlooks to stimulate future research. The book is intended for a wide audience, including students, academics and industrial researchers working in materials science, chemistry and physics. - Addresses a wide range of applications of ceria-based materials, including catalysis, energy production and storage, sensors, cosmetics and toxicology - Provides the fundamentals of ceria-based materials, including synthesis methods, materials properties, toxicology and surface chemistry - Includes nanostructured ceria-based materials and a discussion of future prospects and outlooks
This 21st Century Nanoscience Handbook will be the most comprehensive, up-to-date large reference work for the field of nanoscience. Handbook of Nanophysics by the same editor published in the fall of 2010 and was embraced as the first comprehensive reference to consider both fundamental and applied aspects of nanophysics. This follow-up project has been conceived as a necessary expansion and full update that considers the significant advances made in the field since 2010. It goes well beyond the physics as warranted by recent developments in the field. This seventh volume in a ten-volume set covers bioinspired systems and methods. Key Features: Provides the most comprehensive, up-to-date large reference work for the field. Chapters written by international experts in the field. Emphasises presentation and real results and applications. This handbook distinguishes itself from other works by its breadth of coverage, readability and timely topics. The intended readership is very broad, from students and instructors to engineers, physicists, chemists, biologists, biomedical researchers, industry professionals, governmental scientists, and others whose work is impacted by nanotechnology. It will be an indispensable resource in academic, government, and industry libraries worldwide. The fields impacted by nanophysics extend from materials science and engineering to biotechnology, biomedical engineering, medicine, electrical engineering, pharmaceutical science, computer technology, aerospace engineering, mechanical engineering, food science, and beyond.
This​ book reviews the latest advances and biomedical applications of nanozymes, which are artificial nanomaterials exhibiting enzymatic properties similar to natural enzymes, but with less limitations than natural enzymes. Nanozymes display advantages such as facile synthesis, easy surface modification, improved stability, higher catalytic power, and target-specific binding. Nanozymes containing metals, metal oxides, carbon, and metal sulfide are actually used for cancer therapy, biomolecules sensing, bioimaging, disease diagnostics and diabetes management. The book discloses underlying mechanisms, concepts, recent trends, constraints, and prospects for nanomedicine using nanozymes.
"Advances in Nanomaterials in Biomedicine" provided a platform for more than 110 researchers from different countries to present their latest investigations in various fields of nanotechnology, new methods and nanomaterials intended for medical applications. Modern achievements in the field of nanoparticle-based diagnostics, drug delivery and the use of various nanomaterials in the treatment of diseases are presented in 11 original articles. The published reviews provide a comprehensive analysis of the current information on the use of nanomedicine in the treatment and diagnosis of cancer and liver fibrosis, in the field of solid tissue engineering and in drug delivery systems.
Nano-Optics: Fundamentals, Experimental Methods, and Applications offers insights into the fundamentals and industrial applications of nanoscale light-emitting materials and their composites. This book serves as a reference, offering an overview of existing research, with a particular focus on industrial applications. Nano-optics is the branch of nanoscience and nanotechnology that deals with interaction of light with nanoscale objects. This book explores the materials, structure, manufacturing techniques, and industrial applications of nano-optics. The applications discussed include healthcare, communication, astronomy, and satellites. - Explains the major manufacturing techniques for light-emitting nanoscale materials - Discusses how nanoscale optical materials are being used in a range of industrial applications - Assesses the challenges of using nano-optics in a mass-production context
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Nanomedicinal Approaches Towards Cardiovascular Disease summarizes information about nanotechnology that is used in the diagnosis and regenerative treatment of heart diseases. Chapters in this reference introduce the reader to the basics of cardiac nanomedicine and cardiac regeneration before moving to advanced topics such as nanomedicine in cardiovascular diagnosis, imaging and therapeutics. Key Features - 13 chapters that cover nanotechnological aspects of cardiovascular diseases, contributed by expert scholars - Simple, reader-friendly text suitable for readers of all academic levels - Covers introductory topics of nanomedicine regenerative medicine in cardiovascular disease, cardiovascular diagnosis and therapeutics - Covers advanced topics such as cardiovascular nanotheranositics, cardiac reprogramming, biomimetics, drug delivery systems and smart nanomaterials - Includes a chapter on ethical implications in cardiovascular nanomedicine - Includes bibliographic references for each chapter Nanomedicinal Approaches Towards Cardiovascular Disease is a simple. informative reference on cardiovascular nanomedicine for scholars, healthcare professionals and nanotechnology enthusiasts, alike, which provides holistic knowledge on the subject in a single volume.
Nanobioanalytical Approaches to Medical Diagnostics reviews a range of nanobiomaterials and bioanalytical nano-devices for medical diagnostics. Nanobiomaterials and nano-devices are used in various bioanalytical and biochemical systems to provide real-time, point-of-care diagnostics. The specialized properties of nanoparticles allow them to be engineered and adapted to produce the required effect within a bioanalytical or biochemical system – offering targeted and detailed diagnostic results in a range of biomedical applications. This book covers both traditional biochemical and modern, combined nano-approaches to medical diagnostics. Chapters detail a range of in vitro, in vivo and ex vivo models for nanobioanalytics, including DNA and peptide-based, erythrocyte, microfluidic and more. In addition, sections also look at various different medical diagnostic applications, such as in cancer detection, infectious disease diagnosis and blood glucose sensing. - Covers core principles and nano-approaches in bioanalytics for medical diagnostics - Details a range of in vitro, in vivo and ex vivo models for nanobioanalytics, including spectroscopic analysis, erythrocyte models, microfluidics, and more - Appeals to an interdisciplinary readership, spanning the fields of materials science, biomedical engineering and biochemical engineering
This book provides a systematic overview of the processing and applications of sustainable polymers. The volume covers recent advances in biomedical, food packaging, fuel cell, membrane, and other emerging applications. The book begins by addressing different sections of biomedical application including use of carbohydrate-based therapeutics, nanohybrids, nanohydrogels, bioresorbable polymers and their composites, polymer-grafted nanobiomaterials for biomedical devices and implants, nanofibres, and others. The second part of this book discusses various processing and packaging materials for food packaging applications. The last section discusses other emerging applications, including using microbial fuel cells for waste water treatment, microfluidic fuel cells for low power applications, among others. This volume will be relevant to researchers working to improve the properties of bio-based materials for their advanced application and wide commercialization.