Download Free Cerebral Cavernous Malformations Ccm Book in PDF and EPUB Free Download. You can read online Cerebral Cavernous Malformations Ccm and write the review.

The massive convergence of information about cavernous malformations has been synthesized in this volume by experts in the field of pathology, neuroradiology and neurosurgery. Cavernous Malformations represents state-of-the-art knowledge about this lesion and the spectrum of opinion about its nature, clinical behavior and management strategies. Highlights of Cavernous Malformations: Definition and pathologic features Epidemiology Diagnostic imaging Epilepsy Hemorrhage Conservative management Surgical intervention Microsurgical treatments Spinal cavernous malformations Pediatrics Radiotherapy (Distributed by Thieme for the American Association of Neurological Surgeons)
This volume provides experimental approaches aimed to characterize the Cerebral Cavernous Malformations (CCM) disease and to define the cellular and molecular mechanisms underlying this pathology. Chapters are divided into four sections providing a general overview of the natural history, epidemiology, and pathogenetic mechanisms of CCM disease, describing methods currently used for diagnosis and treatment, production and analysis of distinct cellular and animal models in which CCM can be studied, and different methodological approaches to study the mechanisms underlying the CCM onset and progression. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cerebral Cavernous Malformations (CCM): Methods and Protocols aims to ensure successful results in the further study of this complex disease and its pathophysiologic correlates.
Questions regarding the nature and appropriate management of cavernous malformation (CM) have clouded researchers and those faced with making clinical decisions for several decades. CMs may be seen as an incidental finding on MRI studies, or they may present with symptoms, such as seizures or intracranial hemorrhage, often causing severe neurologic deficit. Cavernous Malformations of the Nervous System provides a comprehensive and authoritative review of the current practice in diagnosis and management of these cerebrovascular disorders. Emphasis has been laid on the understanding of basic sciences with chapters committed to understanding of CCM1, 2 and 3 genes and their role in CCM biology, as well as clinical genetics. Controversial topics which continue to pose treatment challenges such as safety of anticoagulation and prophylactic management during pregnancy are also discussed. This book will be of interest to basic science researchers, neurosurgeons and vascular neurologists both in academic institutions and private practice.
Current techniques for clinical management This book presents a comprehensive overview of the basic science and current clinical knowledge on cavernous malformations of the brain and spinal cord. Cavernous Malformations of the Brain and Spinal Cord begins by covering general aspects of the disease, including the natural history, molecular biology, pathological processes, genetic basis, neuroradiology, and classification of cavernous malformations. Separate chapters then address the various types of cavernous malformations, thoroughly describing the clinical presentation and management approaches for each clinical situation. Incisive review of recent literature sheds light on topics of incidence, location, and outcomes. Features: Clinical insights regarding indications for surgery, surgical techniques, outcomes, and prognostic factors drawn from the authors' extensive experiences Discussion of treatment of patients with specific disorders, such as epilepsy Coverage of cavernous malformations as dynamic lesions with descriptions of de novo formation and lesions induced by irradiation Neurosurgeons, neurologists, and neuroradiologists, especially those caring for patients with seizures and hemorrhagic stroke, will benefit from the wealth of information in this complete reference.
This book presents a complete up-to date description of cavernoma disease together with its known biology, genetics and variable clinical presentation. It facilitates improved decision-making on surgical intervention by presenting different cases, highlighting the particular features of lesions such as anatomical location, eloquences of adjacent brain and type of presentation that are important when making decisions. In addition, the reader is brought up to speed with developments in the neuroimaging and active treatment techniques, especially surgical resection and radiosurgery. Finally, the natural history of the disease is taken into account and compared to the possible benefits of surgical treatment. Cavernomas of the CNS: Basic Science to Clinical Practice provides a comprehensive overview from the fundamentals of this condition, to special patient groups such as children and pregnant women. Therefore, it is an indispensable resource for neurovascular surgeons, neurosurgical residents and neurologists.
This book aims to cover the majority of neurovascular diseases and management. The first section reviews neurovascular anatomy, the basics of angiography, and the basics of craniotomies for neurovascular diseases. Next, an entire section is devoted to intracranial aneurysms, covering the natural history, subarachnoid hemorrhage, endovascular management, microsurgical management, and vasospasm. Following this, a number of chapters are devoted to stroke including natural history, mechanical thrombectomy, intracranial stenosis, Moyamoya disease, bypass surgery, vertebrobasilar insufficiency, intracerebral hemorrhage, sinus thrombosis, and the surgical and endovascular management of extracranial carotid disease. Next, the text covers vascular malformations including arteriovenous malformation, arteriovenous fistulas, carotid cavernous fistulas, vein of Galen malformations, spinal malformations, and cavernous malformations. Finally, the book discusses a few miscellaneous topics including more recent advances in neurovascular care such as venous sinus stenting for idiopathic intracranial hypertension and middle meningeal artery embolization for subdural hematoma. Written by experts in the field, Introduction to Vascular Neurosurgery provides a comprehensive summary of neurovascular disease and management. The book can be used as a daily reference and serves as a trusted resource for medical students, residents, fellows, and young attendings.
Cerebral cavernous malformation (CCM) is a human genetic, cerebrovascular disease that is caused by loss of function mutations in three non-homologous protein coding genes: KRIT1, CCM2, and PDCD10. These proteins form a heterotrimeric CCM adaptor complex that is required in endothelial cells to prevent disease. How loss of this complex causes disease remains unknown. Here, utilizing a neonatal mouse model of disease, we demonstrate that the CCM complex negatively regulates Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3 aka MEKK3) signaling in endothelial cells. During disease, loss of the CCM complex results in gain of MEKK3 signaling and pathologic overexpression of downstream target transcription factors Kruppel-like Factor 2 and Kruppel-like factor 4 (KLF2 and KLF4). This endothelial MEKK3-KLF2/4 signaling pathway represents the proximal signaling events that are required for lesion formation. If the CCM complex negatively regulates MEKK3 signaling, what are the upstream activators of MEKK3 in the context of disease? We demonstrate that gram-negative bacterial infection and lipopolysaccharide (LPS) activation of endothelial Toll-like receptor 4 (TLR4) drives MEKK3 signaling to stimulate lesion formation. Commensal bacteria in the gut microbiome produce the vast majority of endogenous LPS. We further show through germ-free and broad-spectrum antibiotic experiments, along with 16S fecal analysis of mice spontaneously resistant to lesion formation, that the gram-negative, bacterial microbiome is a primary driver of lesion formation. These studies reveal that endothelial TLR4--MEKK3--KLF2/4 signaling is required for lesion formation and that inhibition of this pathway may be of therapeutic value for CCM patients. They further demonstrate an unexpected role for the gut microbiome in this cerebrovascular disease and suggest that manipulation of host-microbiome interactions may be a viable therapeutic strategy for this lifelong, progressive disease.
This book covers topical issues in neurovascular surgery, and in particular the management of intracranial aneurysms, arteriovenous malformations, and cavernomas, current trends in cerebral revascularization, and new concepts in cerebrovascular imaging. The contents reflect the continuing developments in interventions in cerebrovascular disorders as a result of progress in neuroimaging, evolution of pathophysiological concepts, new clinical trials, and technological innovations. The chapters are all written by acknowledged experts from across the world, and comprise original papers presented at the 6th European Japanese Stroke Surgery Conference, held in June 2012 in Utrecht, The Netherlands. The book will be of value to all who are interested in the latest developments in the field and offers fascinating insights into varied perspectives and techniques.
This book presents a detailed overview of a spectrum of pediatric neurosurgical conditions. It features detailed insight into the techniques available for examining abnormalities, hemorrhages and a variety of tumors. Relevant surgical methodologies are described in relation to a clinical problem or disorder, ensuring that the reader can systematically develop their knowledge of how to perform both routine and more-obscure procedures presently utilized to treat these conditions. Pediatric Neurosurgery for Clinicians is a comprehensive guide detailing methodologies for applying a range of surgical techniques based upon a range of clinical questions. Therefore, it is a critical resource for all practicing and trainee physicians who encounter children with disorders affecting their neurological systems in disciplines within neurosurgery, neurology, radiology, oncology and pathology.
Most imaging books are ordered according to underlying etiology. However, in real life clinical practice, radiologists usually make their differential diagnoses according to the image patterns, as the etiology is often unknown. Brain Imaging with MRI and CT presents over 180 disease processes and normal variants, grouping entities by these basic patterns to accentuate differential diagnostic features. High quality CT and MRI scans show multiple typical and distinguishing images for each entity. Common and unusual clinical scenarios are described, including dilated perivascular spaces, capillary teleangiectasia, Susac's syndrome and desmoplastic infantile ganglioglioma. Both basic and advanced imaging techniques are used, reflecting the reality of clinical practice. This image-focused book emphasises the most pertinent clinical information relevant to the diagnostic process. Trainee and practising radiologists will find Brain Imaging with MRI and CT an invaluable and clinically relevant tool for learning and teaching.