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During development, cells are generated at specific locations within the embryo and then migrate into their destinations. At their destinations, they assemble together through cell adhesions, eventually leading to the formation of tissues and organs. In some cases, orchestration of cell adhesion and migration produces the global movement of cell groups, called collective cell migration, which is also required for the development of basic tissue structures such as spheres, clusters, and vesicles in the morphogenetic processes of development. Therefore, individual regulation and orchestration of cell adhesion and migration are quite important for appropriate tissue/organ formation during development. However, how cell adhesion and migration are regulated, and orchestrated during development? How cell adhesion and migration affects tissue formation during development? To answer these questions, we assembled several review and research articles in this eBook. By assembling these articles, we could explore the presence of core regulatory mechanisms and deepen the current understanding of cell adhesion and migration during the development of multicellular organisms.
Among the most important innovations in the history of life is the transition from single-celled organisms to more complex, multicellular organisms. Multicellularity has evolved repeatedly across the tree of life, resulting in the evolution of new kinds of organisms that collectively constitute a significant portion of Earth’s biodiversity and have transformed the biosphere. This volume examines the origins and subsequent evolution of multicellularity, reviewing the types of multicellular groups that exist, their evolutionary relationships, the processes that led to their evolution, and the conceptual frameworks in which their evolution is understood. This important volume is intended to serve as a jumping-off point, stimulating further research by summarizing the topics that students and researchers of the evolution of multicellularity should be familiar with, and highlighting future research directions for the field.
Explores a Range of Multiscale Biomechanics/Mechanobiology ConceptsCell and Matrix Mechanics presents cutting-edge research at the molecular, cellular, and tissue levels in the field of cell mechanics. This book involves key experts in the field, and covers crucial areas of cell and tissue mechanics, with an emphasis on the roles of mechanical forc
Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.
This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.
A unique account of the biology, ecology and evolution of choanoflagellates - the closest, known, living, unicellular relatives of animals.
If you had a complete copy of a dinosaur's DNA and the genetic code, you still would not be able to make a dinosaur—or even determine what one looked like. Why? How do animals get their shape and how does shape evolve? In this important book, Nobel laureate Gerald M. Edelman challenges the notion that an understanding of the genetic code and of cell differentiation is sufficient to answer these questions. Rather, he argues, a trio of related issues must also be investigated—the development of form, the evolution of form, and the morphological and functional bases of behavior. Topobiology presents an introduction to molecular embryology and describes a comprehensive hypothesis to account for the evolution and development of animal form.
During gastrulation, tissue layers are formed and the overall body plan is established. This book is the definitive guide to this vitally important period in embryonic development, providing authoritative and up to date information that includes the first comprehensive interspecies comparison, cell movements and patterning events, the roles of individual genes and gene families, and the evolution of gastrulation.
Most of the cranial sense organs of vertebrates arise from embryonic structures known as cranial placodes. Such placodes also give rise to sensory neurons that transmit information to the brain as well as to many neurosecretory cells. This book focuses on the development of sensory and neurosecretory cell types from cranial placodes by introducing the vertebrate head with its sense organs and neurosecretory organs and providing an overview of the various cranial placodes and their derivatives, including evidence of common embryonic primordia. Schlosser discusses how these primordia are established in the early embryo and how individual placodes develop. The latter chapters explain how various placodally derived sensory and neurosecretory cell types differentiate into discrete structures.