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Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of Springer Nature’s long-standing and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the twelfth volume of a continuing series.
The T Cell Receptor FactsBook contains entries on all the 176 functional variable, diversity, joining, and constant regions of the human T cell receptor, including alpha, beta, gamma, and delta loci. Introductory chapters summarize information of T cell receptor chain synthesis, chromosomal location, and an overview of the human T cell receptor loci.
For many years, I have been interested in global analysis of nonlinear systems. The original interest stemmed from the study of snap-through stability and jump phenomena in structures. For systems of this kind, where there exist multiple stable equilibrium states or periodic motions, it is important to examine the domains of attraction of these responses in the state space. It was through work in this direction that the cell-to-cell mapping methods were introduced. These methods have received considerable development in the last few years, and have also been applied to some concrete problems. The results look very encouraging and promising. However, up to now, the effort of developing these methods has been by a very small number of people. There was, therefore, a suggestion that the published material, scattered now in various journal articles, could perhaps be pulled together into book form, thus making it more readily available to the general audience in the field of nonlinear oscillations and nonlinear dynamical systems. Conceivably, this might facilitate getting more people interested in working on this topic. On the other hand, there is always a question as to whether a topic (a) holds enough promise for the future, and (b) has gained enough maturity to be put into book form. With regard to (a), only the future will tell. With regard to (b), I believe that, from the point of view of both foundation and methodology, the methods are far from mature.
An authoritative guide to up-to-date research results on chaotic signal processing aimed at researchers and graduate students in chaos, applied nonlinear dynamics, signal processing and radar communications. This book examines the applications of chaotic signal processing to radar, communications, system identification and computing.
Basic Science Methods for Clinical Researchers addresses the specific challenges faced by clinicians without a conventional science background. The aim of the book is to introduce the reader to core experimental methods commonly used to answer questions in basic science research and to outline their relative strengths and limitations in generating conclusive data. This book will be a vital companion for clinicians undertaking laboratory-based science. It will support clinicians in the pursuit of their academic interests and in making an original contribution to their chosen field. In doing so, it will facilitate the development of tomorrow’s clinician scientists and future leaders in discovery science. Serves as a helpful guide for clinical researchers who lack a conventional science background Organized around research themes pertaining to key biological molecules, from genes, to proteins, cells, and model organisms Features protocols, techniques for troubleshooting common problems, and an explanation of the advantages and limitations of a technique in generating conclusive data Appendices provide resources for practical research methodology, including legal frameworks for using stem cells and animals in the laboratory, ethical considerations, and good laboratory practice (GLP)
Review of orthopaedic oncology with case presentations illustrating how each tumor would be diagnosed and managed in a clinical setting.
This series was established to create comprehensive treatises on specific topics in developmental biology. Such volumes serve a useful role in developmental biology, which is a very diverse field that receives contributions from a wide variety of disciplines. This series is a meeting ground for the various practi tioners of this science, facilitating an integration of heterogeneous information on specific topics. Each volume is comprised of chapters selected to provide the conceptual basis for a comprehensive understanding of its topic as well as an analysis of the key experiments upon which that understanding is based. The specialist in any aspect of developmental biology should understand the experimental back ground of the specialty and be able to place that body of information in context, in order to ascertain where additional research would be fruitful. The creative process then generates new experiments. This series is intended to be a vital link in that ongoing process of learning and discovery.