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This book presents a case history of a patient with leukocyte adhesion deficiency to illustrate essential points about the mechanisms of immunity and to explain some of the immunological problems often seen in the clinic. It is helpful for medical and pre-medical students.
This book presents case histories to illustrate in a clinical context essential points about the mechanisms of immunity. It includes cases that illustrate both recently discovered genetic immunodeficiencies and some more familiar and common diseases with interesting immunology.
This case study is about a 29-year-old professional oboe player who was first diagnosed for optic neuritis and then for multiple sclerosis (MS). MS is an example of a T-cell mediated autoimmune disease, wherein there is an autoimmune attack on the integrity of the central nervous system.
Case Studies in Veterinary Immunology presents basic immunological concepts in the context of actual cases seen in clinics. It is intended for veterinary medicine students, interns, residents, and veterinarians, and serves as a valuable supplement and companion to a variety of core immunology textbooks and courses. The book includes cases describing primary immune system defects, secondary immune system defects, and hypersensitivity and autoimmune disorders, as well as dysproteinemias and lymphoid neoplasia. Drawing on the successful approach of Geha’s Case Studies in Immunology, each representative case is preceded by a discussion of the principles underlying that specific immunological mechanism. The case itself includes the presenting complaint (signalment), physical examination findings, pertinent diagnostic laboratory data, diagnosis, and treatment options. In those instances in which a specific disorder occurs in both animals and humans, the differences and similarities in the immunological mechanisms and manifestations of the disease are explored. End of case questions highlight important concepts and serve as a review aid for students. Details on standard vaccines and vaccination schedules, as well as descriptions of the types of assays used for evaluation of the immune system, are included as appendices.
This book presents case histories to illustrate in a clinical context essential points about the mechanisms of immunity. It includes cases that illustrate both recently discovered genetic immunodeficiencies and some more familiar and common diseases with interesting immunology.
The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References
Clinical Case Studies for the Family Nurse Practitioner is a key resource for advanced practice nurses and graduate students seeking to test their skills in assessing, diagnosing, and managing cases in family and primary care. Composed of more than 70 cases ranging from common to unique, the book compiles years of experience from experts in the field. It is organized chronologically, presenting cases from neonatal to geriatric care in a standard approach built on the SOAP format. This includes differential diagnosis and a series of critical thinking questions ideal for self-assessment or classroom use.
The ONLY handbook on pediatric hospitalist medicine! Focusing specifically on caring for pediatric patients in the hospital setting, this unique handbook addresses more than 350 of the most commonly encountered inpatient pediatric medical conditions. Unlike similar handbooks on the subject, The Philadelphia Guide goes beyond diagnostic strategies to include complete treatment and management guidelines. The emphasis on the treatment of so many inpatient conditions makes the book valuable to anyone who cares for pediatric patients in the hospital – medical students, residents, and pediatric attendings. Designed for immediate access, the handbook features alphabetized clinical sections and consistent chapter subheadings to make the book especially useful at the point of care. Valuable appendices include pediatric vital signs, neonatal codes, and PALS (pediatric advance life support) algorithms Includes evidence-based references NEW 2-color design
Case Studies in Veterinary Immunology presents basic immunological concepts in the context of actual cases seen in clinics. It is intended for veterinary medicine students, interns, residents, and veterinarians, and serves as a valuable supplement and companion to a variety of core immunology textbooks and courses. The book includes cases describing primary immune system defects, secondary immune system defects, and hypersensitivity and autoimmune disorders, as well as dysproteinemias and lymphoid neoplasia. Drawing on the successful approach of Geha’s Case Studies in Immunology, each representative case is preceded by a discussion of the principles underlying that specific immunological mechanism. The case itself includes the presenting complaint (signalment), physical examination findings, pertinent diagnostic laboratory data, diagnosis, and treatment options. In those instances in which a specific disorder occurs in both animals and humans, the differences and similarities in the immunological mechanisms and manifestations of the disease are explored. End of case questions highlight important concepts and serve as a review aid for students. Details on standard vaccines and vaccination schedules, as well as descriptions of the types of assays used for evaluation of the immune system, are included as appendices.
This book presents case histories to illustrate in a clinical context essential points about the mechanisms of immunity. It includes cases that illustrate both recently discovered genetic immunodeficiencies and some more familiar and common diseases with interesting immunology.