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This updated and revised edition delineates the basic concepts and fundamental principles needed to grasp current issues in modern toxicology. In addition, new contributions help to redefine the book's scope and coverage, and illuminate new and emerging areas of toxicologic interest.
The most complete, trusted reference-text covering the full span of medical toxicology Market: Students, toxicologists, and pharmacologists Focuses on the principles, concepts, and modes of thought that are the foundation of the discipline New to this edition: updated throughout to reflect new understanding of cell death and drug metabolism, new content on chemical terrorism, many new contributors
Reflecting more than a decade's worth of changes, Animal Models in Toxicology, Second Edition is a practical guide to the common statistical problems encountered in toxicology and the methodologies that are available to solve them. The book presents a historical review of the use of animal models and an overview of broad considerations of me
Focusing primarily on basic principles and concepts, Toxicology also provides 200 tables worth of toxicological data. Each heavily illustrated chapter is a complete study unit containing a table of contents, an introduction, a learning core, a self-test, and feedback. The main text for the unit is followed by a self-test, which reveals whether the learning objectives have been met. The feedback section answers frequently asked questions, while a summary enables the student to review the main concepts before moving on to the next unit.
This time-saving, pocket-size guide offers a thorough understanding of toxicology that is essential to diagnosing and treating the complex problems resulting from toxin ingestion, a leading cause of morbidity and mortality in animals. The 2nd edition covers patient assessment and treatment techniques, as well as information on over 100 categories of toxic agents. Discussions of each agent include its uses, mechanism, pathophysiology, clinical signs, diagnosis, common products containing the agent, and acute and long-term treatment. A new avian section makes this edition even more comprehensive and clinically useful. Over 1,000 toxic agents are discussed, offering a thorough presentation of toxicology relevant to veterinary practice. An easy-to-use alphabetical organization with section tabs for quick reference makes information easy to locate in any setting. Detailed diagnostic and treatment information is presented in an appealing, visually accessible approach. A greater emphasis on the ingestion of human medications addresses this common concern in detail. Additional plant and chemical toxins are discussed to highlight potential poisonings seen in veterinary practice. A new avian section focuses on specific considerations for treating birds. Redesigned icons draw attention to important points and sections to improve the text's readability. A four-page, full-color insert features approximately 24 color photographs of poisonous plants for quick identification. All content has been reviewed by board-certified toxicologists to ensure that it is up-to-date and accurate. A second color throughout makes the icons more readable, the design more inviting, and critical information more accessible.
Written by two experienced toxicology lecturers, Principles of Toxicology provides a broad-based yet in-depth introduction to this diverse subject. Comprehensive and easy-to-read, the book covers this broad and interdisciplinary field from the viewpoint of three different functional levels: molecular and cellular; physiological; and ecological and environmental. This revised second edition expands the coverage of the book while keeping the organizational format that made the first edition a bestseller. It also includes a series of brief case studies illustrating the application of toxicological principles to current issues of interest. Each and every chapter has been revised, several have been significantly rewritten, and three are entirely new. This new edition retains the extensive cross-referencing system that links all sections and enhances the integration of material. It also includes an appendix of selected toxicants that describes chemical structure and category of use. These features combine to make finding specific information quick and easy. The highly readable format and uniform, consistent presentation of information will make this the most used reference on your shelf. See what's new in the second edition:
This book provides a readable introduction to modern toxicology with a particular focus on the mechanisms underlying the induction of toxicity by foreign substances. Since bioactivation is central to many toxic syndromes, special interest is devoted to chemicals that undergo conversion to toxic metabolites that induce toxic effects as diverse as cancer, birth defects and organ injury. The molecular consequences accompanying damage to cellular DNA and proteins is explored together with the relevance of toxicological paradigms to human diseases caused by alcohol and tobacco. The discipline of toxicology has developed rapidly since the thalidomide disaster in the 1960’s as scientists worldwide seek to understand the adverse health effects of human medicines, environmental pollutants, consumer chemicals and industrial reagents. An Introduction to Toxicology is intended to supplement the recommended reading list of undergraduate and graduate programs in toxicology and pharmacology as an enjoyable, accessible primer with illustrations that “unpack” the concepts being discussed in the text. ​
This second edition provides a synthesis of recent research on the mechanisms of chemically-induced kidney injury. The text includes a review of current concepts of clinical nephrotoxicity and renal failure, and mechanisms of specific classes of nephrotoxic drugs and environmental chemicals.