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Reprint of the original, first published in 1875.
"Now with a new afterword by the author"--Back cover.
"You can choose to see a trial as a roadblock or an expressway. If you see it as a roadblock, it will obstruct your way. However, if you see it as an expressway, you can use it to learn and grow." "The gospel of Jesus Christ is the plan whereby we can become what God wants us to become. In fact, we become great people because of our trials, not in spite of them." This booklet reviews the nature, origins, and purposes of adversity and includes suggestions on how to patiently trust in the Lord and His eternal plan and how to use these trials to learn and grow stronger. You can benefit from your trials if you: Develop a relationship with God Let others help you Let God carry your burdens Trust that the Lord is in control and allow His will to be done Remember that everyone has challenges Let adversity make you a better person Live with integrity Be patient Make the best of your situation Serve others Keep a positive attitude Keep an eternal perspective
Cross-over trials are an important class of design used in the pharmaceutical industry and medical research, and their use continues to grow. Cross-over Trials in Clinical Research, Second Edition has been fully updated to include the latest methodology used in the design and analysis of cross-over trials. It includes more background material, greater coverage of important statistical techniques, including Bayesian methods, and discussion of analysis using a number of statistical software packages. * Comprehensive coverage of the design and analysis of cross-over trials. * Each technique is carefully explained and the mathematics is kept to a minimum. * Features many real and original examples, taken from the author's vast experience. * Includes discussion of analysis using SAS, S-Plus and, GenStat, StatXact and Excel. * Written in a style suitable for statisticians and physicians alike. * Computer programs to accompany the examples in the book can be downloaded from the Web Primarily aimed at statisticians and researchers working in the pharmaceutical industry, the book will also appeal to physicians involved in clinical research and students of medical statistics.
Data sharing can accelerate new discoveries by avoiding duplicative trials, stimulating new ideas for research, and enabling the maximal scientific knowledge and benefits to be gained from the efforts of clinical trial participants and investigators. At the same time, sharing clinical trial data presents risks, burdens, and challenges. These include the need to protect the privacy and honor the consent of clinical trial participants; safeguard the legitimate economic interests of sponsors; and guard against invalid secondary analyses, which could undermine trust in clinical trials or otherwise harm public health. Sharing Clinical Trial Data presents activities and strategies for the responsible sharing of clinical trial data. With the goal of increasing scientific knowledge to lead to better therapies for patients, this book identifies guiding principles and makes recommendations to maximize the benefits and minimize risks. This report offers guidance on the types of clinical trial data available at different points in the process, the points in the process at which each type of data should be shared, methods for sharing data, what groups should have access to data, and future knowledge and infrastructure needs. Responsible sharing of clinical trial data will allow other investigators to replicate published findings and carry out additional analyses, strengthen the evidence base for regulatory and clinical decisions, and increase the scientific knowledge gained from investments by the funders of clinical trials. The recommendations of Sharing Clinical Trial Data will be useful both now and well into the future as improved sharing of data leads to a stronger evidence base for treatment. This book will be of interest to stakeholders across the spectrum of research-from funders, to researchers, to journals, to physicians, and ultimately, to patients.
The Model Rules of Professional Conduct provides an up-to-date resource for information on legal ethics. Federal, state and local courts in all jurisdictions look to the Rules for guidance in solving lawyer malpractice cases, disciplinary actions, disqualification issues, sanctions questions and much more. In this volume, black-letter Rules of Professional Conduct are followed by numbered Comments that explain each Rule's purpose and provide suggestions for its practical application. The Rules will help you identify proper conduct in a variety of given situations, review those instances where discretionary action is possible, and define the nature of the relationship between you and your clients, colleagues and the courts.
"I have learned to kiss the wave that throws me against the Rock of Ages." What does it mean to "kiss the wave?" These words, attributed to nineteenth-century British preacher Charles Spurgeon, speak to the Christian's only hope for perseverance in suffering. What if we can learn to experience the nearness of God in the midst of suffering? What if God intends to work through our trials rather than simply take them away? After living for more than a decade with a debilitating nerve condition in both arms, Dave Furman shows us that God, in his grace, always designs trials for our good—not minimizing the pain, but infusing significance into our suffering. Furman demonstrates that, even when tossed to and fro by stormy waves, God is near . . . and that makes all the difference in the world.