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Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.
The opioid crisis in the United States has come about because of excessive use of these drugs for both legal and illicit purposes and unprecedented levels of consequent opioid use disorder (OUD). More than 2 million people in the United States are estimated to have OUD, which is caused by prolonged use of prescription opioids, heroin, or other illicit opioids. OUD is a life-threatening condition associated with a 20-fold greater risk of early death due to overdose, infectious diseases, trauma, and suicide. Mortality related to OUD continues to escalate as this public health crisis gathers momentum across the country, with opioid overdoses killing more than 47,000 people in 2017 in the United States. Efforts to date have made no real headway in stemming this crisis, in large part because tools that already existâ€"like evidence-based medicationsâ€"are not being deployed to maximum impact. To support the dissemination of accurate patient-focused information about treatments for addiction, and to help provide scientific solutions to the current opioid crisis, this report studies the evidence base on medication assisted treatment (MAT) for OUD. It examines available evidence on the range of parameters and circumstances in which MAT can be effectively delivered and identifies additional research needed.
The Bristol Law Journal is composed of academic articles written by either current or alumni students of the University of Bristol. Contributors were asked to submit articles on ‘Law Reform’, in any area of their choice and this broad mandate has produced a richly diverse range of reading.
The misuse of drugs continues to cause suffering and worldwide economic turmoil. In response to these problems, many have devoted their lives to preventing the misuse of mind-altering substances. Addiction and the Making of Professional Careers focuses on the need for enhanced understanding of professional careers in the addiction field. The spectrum of professionals involved is wide and includes treatment personnel of every kind. Some of the questions examined here include: Why do some people decide to dedicate their lives to responding to drug problems? How do and should we select, train, mentor, support, inspire, and nurture the young career aspirant? What makes for the most effective use of talent? Is every personal case different or can general conclusions be reached? After a foreword by William Miller and an introduction by Griffith Edwards, the book includes interviews with Joseph Brady, Louis Harris, Conan Kornetsky, and Robert DuPont, all of whom were pioneers in the behavioral pharmacological analysis of addiction. Commentary chapters are written by Kerstin Stenius, Ilana Crome, Peter Anderson, and Jonathan Chick.