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This book highlights recent technological advances, reviews and applications in the field of cardiovascular engineering, including medical imaging, signal processing and informatics, biomechanics, as well as biomaterials. It discusses the use of biomaterials and 3D printing for tissue-engineered heart valves, and also presents a unique combination of engineering and clinical approaches to solve cardiovascular problems. This book is a valuable resource for students, lecturers and researchers in the field of biomedical engineering.
This book provides a guiding thread between the distant fields of fluid mechanics and clinical cardiology. Well rooted in the science of fluid dynamics, it drives the reader across progressively more realistic scenarios up to the complexity of routine medical applications. Based on the author’s 25 years of collaborations with cardiologists, it helps engineers learn communicating with clinicians, yet maintaining the rigor of scientific disciplines. This book starts with a description of the fundamental elements of fluid dynamics in large blood vessels. This is achieved by introducing a rigorous physical background accompanied by examples applied to the circulation, and by presenting classic and recent results related to the application of fluid dynamics to the cardiovascular physiology. It then explores more advanced topics for a physics-based understanding of phenomena effectively encountered in clinical cardiology. It stands as an ideal learning resource for physicists and engineers working in cardiovascular fluid dynamics, industry engineers working on biomedical/cardiovascular technology, and students in bio-fluid dynamics. Written with a concise style, this textbook is accessible to a broad readership, including students, physical scientists and engineers, offering an entry point into this multi-disciplinary field. It includes key concepts exemplified by illustrations using cutting-edge imaging, references to modelling and measurement technologies, and includes unique original insights.
Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. Cardiovascular engineering principles and practices with a focus on disease prevention Aimed at advanced students taking cardiovascular, regenerative, and tissue engineering courses, Cardiovascular Engineering: A Protective Approach explores applications of protective engineering strategies and technologies to common cardiovascular disorders. A protective approach to cardiovascular engineering involves studying the naturally occurring mechanisms that protect molecules, cells, and organs from injury and dysfunction. The goal is to use this understanding to design and develop engineering-based therapeutic strategies and technologies that prevent cardiovascular injury and disease. Readers will learn the fundamental and applied aspects of cardiovascular engineering. Coverage includes: • Foundations of cardiovascular protective engineering • Development of the heart, blood vessels, and blood cells • Stem cells and regeneration • Structure and function of the heart and blood vessels • Cytokines and growth factors in cardiovascular disease • Mechanisms of disease • Systems protective mechanisms against injury • Protective engineering strategies • Systemic hypertension • Atherosclerosis and arterial aneurysms • Ischemic heart disease and ischemic stroke • Cardiomyopathies and congenital heart disease
For the first time, this invaluable book shows how cardiac perfusion and pumping can be quantified and correlated. Self-contained and unified in presentation, the explanations in the compendium are detailed enough to capture the reader's curiosity and complete enough to provide the background material to explore further into the subject.Mathematically rigorous and clinically oriented, the book is a major resource for biomedical engineers, cardiologists, cardiac surgeons and clinicians. For students, it is an ideal textbook for senior-level courses in cardiovascular engineering.
This book is a comprehensive and up-to-date resource on the use of regenerative medicine for the treatment of cardiovascular disease. It provides a much-needed review of the rapid development and evolution of bio-fabrication techniques to engineer cardiovascular tissues as well as their use in clinical settings. The book incorporates recent advances in the biology, biomaterial design, and manufacturing of bioengineered cardiovascular tissue with their clinical applications to bridge the basic sciences to current and future cardiovascular treatment. The book begins with an examination of state-of-the-art cellular, biomaterial, and macromolecular technologies for the repair and regeneration of diseased heart tissue. It discusses advances in nanotechnology and bioengineering of cardiac microtissues using acoustic assembly. Subsequent chapters explore the clinical applications and translational potential of current technologies such as cardiac patch-based treatments, cell-based regenerative therapies, and injectable hydrogels. The book examines how these methodologies are used to treat a variety of cardiovascular diseases including myocardial infarction, congenital heart disease, and ischemic heart injuries. Finally, the volume concludes with a summary of the most prominent challenges and perspectives on the field of cardiovascular tissue engineering and clinical cardiovascular regenerative medicine. Cardiovascular Regenerative Medicine is an essential resource for physicians, residents, fellows, and medical students in cardiology and cardiovascular regeneration as well as clinical and basic researchers in bioengineering, nanomaterial and technology, and cardiovascular biology.
The objective of this book is to illustrate in specific detail how cardiovascular mechanics stands as a common pillar supporting such different clinical successes as drugs for high blood pressure, prosthetic heart valves and coronary artery bypass grafting, among others. This information is conveyed through a comprehensive treatment of the overarching principles and theories that are behind mechanobiological processes, aortic and arterial mechanics, atherosclerosis, blood and microcirculation, hear valve mechanics, as well as medical devices and drugs. Examines all major theoretical and practical aspects of mechanical forces related to the cardiovascular system. Discusses a unique coverage of mechanical changes related to an aging cardiovascular system. Provides an overview of experimental methods in cardiovascular mechanics. Written by world-class researchers from Canada, the US and EU. Extensive references are provided at the end of each chapter to enhance further study. Michel R. Labrosse is the founder of the Cardiovascular Mechanics Laboratory at the University of Ottawa, where he is a full professor within the Department of Mechanical Engineering. He has been an active researcher in academia along with being heavily associated with the University of Ottawa Heart Institute. He has authored or co-authored over 90 refereed communications, and supervised or co-supervised over 40 graduate students and post-docs.
Advances of cardiovascular engineering prompt one to consider innovative device technology - that is, the development of new replacement heart valves or engineering of a totally implantable energy source for an artificial heart. However, these kinds of advances have often proved unable to achieve a long-lasting benefit as the cardiovascular field has matured so fast. Cardiovascular engineering has matured to the point where a major innovation must not only function, but must continuously function better than existing devices. This is difficult to accomplish in the complex cardiovasculature system, in which energy source, biocompatibility, compliance, and functionality all must be considered. The maturation of the field is evident from the fact that many engineered prosthetic systems perform well - for example, heart valves function for long periods of time, large-vessel vascular grafts are quite adequate, extracorporeal membrane oxygenation has significantly prolonged the feasible length of heart bypass and other surgical operations, and total artificial hearts can be used as a bridge to transplant without serious complications, yet none of these systems is as good as the natural ones it replaces. The reasons for this are many and incompletely understood. The next stage of progress must be better to alterations understandings of the various components of vasculature and their response by our devices, be they at the micro- or macro-circulatory levels, in the blood, or associated with the vascular wall.
Cardiac Tissue Engineering: Methods and Protocols presents a collection of protocols on cardiac tissue engineering from pioneering and leading researchers around the globe. These include methods and protocols for cell preparation, biomaterial preparation, cell seeding, and cultivation in various systems. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cardiac Tissue Engineering: Methods and Protocols highlights the major techniques, both experimental and computational, for the study of cardiovascular tissue engineering.
Biofliudics has gained in importance in recent years, forcing engineers to redefine mechanical engineering theories and apply them to biological functions. To date, no book has successfully done this. Biofliud Mechanics in Cardiovascular Systems is one of the first books to take an interdisciplinary approach to the subject. Written by a professor and researcher, this book will combine engineering principles with human biology to deliver a text specifically designed for biomedical engineering professionals and students.