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At first glance, Carag looks like a normal boy. But behind his shining eyes hides a secret: Carag is a puma shapeshifter and has only recently started living in the human world. Half human, half mountain lion, Carag grew up in the wilderness of the Rocky Mountains. He can’t help but wonder what life as a human would be like even though his curiosity divides him with his family of mountain lions and puts him in great danger. When he finds out about a secret boarding school for Woodwalkers like him, that he felt a sense of home. He makes friends in Holly, a cheeky red squirrel, and Brandon, a shy bison. And Carag can really use it - because the world of Woodwalkers is full of puzzles and dangers . . .
The Rudy Bruner Award for Urban Excellence (RBA) is a national award for urban places that promotes innovative thinking about the built environment. Established in 1987, the award celebrates urban places distinguished by quality design-design that considers form in conjunction with social, economic, and environmental issues.
A wonderful new middle grade series in shapeshifting genre! At first glance, Carag looks like a normal boy. But behind his shining eyes hides a secret: Carag is a puma shapeshifter and has only recently started living in the human world. Half human, half mountain lion, Carag grew up in the wilderness of the Rocky Mountains. He can’t help but wonder what life as a human would be like even though his curiosity divides him with his family of mountain lions and puts him in great danger. When he finds out about a secret boarding school for Woodwalkers like him, that he felt a sense of home. He makes friends in Holly, a cheeky red squirrel, and Brandon, a shy bison. And Carag can really use it - because the world of Woodwalkers is full of puzzles and dangers...
Beginning with a historical analysis of the origins of the Philippine dependency relationship with the United States, the book goes on to argue that the Philippine State acquired some degree of autonomy in formulating national policies. It reveals that while the Philippine political system is based on free wheeling capitalism led by private enterprise, State intervention in the economy has been more extensive than the economic ideology suggests.
The unique biology of cardiac fibroblasts and related cells, such as cardiac myofibroblasts and valvular interstitial cells, distinguish them from other fibroblastic cells, a concept that is only beginning to be widely appreciated. Further, the natural signals that stimulate and inhibit cardiac fibrosis within these cells are not well understood. This volume compiles articles that address the molecular mechanisms that control the synthesis and secretion of the cardiac ECM. The book showcases chapters that highlight discussion of role of Transforming Growth Factor β (TGFβ), an important fibrogenic cytokine and its downstream effectors SMAD in many cardiac diseases. Further, the contributions highlight information to discuss endogenous inhibitors of cardiac fibrosis, as well as advances in tissue engineering specific to matrix in the heart. Finally, discussions of unifying mechanisms of matrix remodeling in valves and myocardium are presented. The mechanisms involved in the stimulation of cardiac fibrosis are not fully understood. In most cases the marginal attenuation of cardiac fibrosis as a result of a given therapy is a beneficial side-effect linked to other primary effects on other cells, especially cardiomyocytes. Very few drugs or agents are known to affect the function and dysfunction of cardiac fibroblasts and myofibroblasts alone. The book helps to translate the information gathered within to allow us to alter the course of fibrogenic events that are typical of cardiac fibrosis, and thereby reduce their burden on the patient and on society itself.
"Artificial Intelligence (AI), the new frontier of human evolution, holds the promise of reuniting religion and science"--
DIV Chastity Riley and her friends are held hostage in a hotel bar by twelve armed men set on revenge, in a searing, breathtakingly original new thriller from the 'Queen of Krimi'. 'Simone Buchholz writes with real authority and a pungent, noir-is sense of time and space ... a palpable hit' Independent 'Reading Buchholz is like walking on firecrackers ... a truly unique voice in crime fiction' Graeme Macrae Burnet 'If Philip Marlowe and Bernie Gunther had a literary love child, it might just explain Chastity Riley – Simone Buchholz's tough, acerbic, utterly engaging central character' William Ryan _______________ Twenty floors above the shimmering lights of the Hamburg docks, Public Prosecutor Chastity Riley is celebrating a birthday with friends in a hotel bar when twelve heavily armed men pull out guns, and take everyone hostage. Among the hostages is Konrad Hoogsmart, the hotel owner, who is being targeted by a young man whose life – and family – have been destroyed by Hoogsmart's actions. With the police looking on from outside – their colleagues' lives at stake – and Chastity on the inside, increasingly ill from an unexpected case of sepsis, the stage is set for a dramatic confrontation ... and a devastating outcome for the team ... all live streamed in a terrifying bid for revenge. Crackling with energy and populated by a cast of unforgettable characters, Hotel Cartagena is a searing, relevant thriller that will leave you breathless. _______________ Praise for the Chastity Riley series 'Caustic, incisive prose. A street-smart, gutsy heroine. A timely and staggeringly stylish thriller' Will Carver 'With plenty of dry humour and a good old dash of despair, Simone Buchholz is an unconventional, refreshing new voice' Crime Fiction Lover 'Lyrical and pithy' Sunday Times 'With brief, pacy chapters and fizzling dialogue, this almost feels like American procedural noir and not a translation' Maxim Jakubowski, Crime Time 'There is a fantastic pace to the story which keeps you hooked from the first sentence all the way to the end ... a unique voice that delivers a stylish story' New Books Magazine 'A smart and witty book that shines a probing spotlight on society' CultureFly 'Fans of Brookmyre could do worse than checking out Simone Buchholz, a star of the German crime lit scene who has been deftly translated into English by Rachel Ward' Goethe Institute 'Stripped back in style and deadpan in voice ... a scintillating romp around the German criminal underworld and back' Doug Johnstone, Big Issue 'By turns lyrical and pithy, this adventure set in the melting pot of contemporary Hamburg has a plot and a sensibility that both owe something to mind-altering substances. Lots of fun' Sunday Times 'Disgraced state prosecutor Chastity Riley chases round the dive bars of the port city pursuing and being pursued by a beguiling cast of cops, criminals and chums, delivering scalding one-liners as she goes' The Times 'Great sparkling energy, humour and stylistic verve ... and the story itself is gripping and pacey' Rosie Goldsmith, European Literature Network 'A must-read, stylish and highly original take on the detective novel, written with great skill and popping with great characters' Judith O'Reilly, author of Killing State 'Constantly surprising … an original, firecracker of a read' LoveReading /div