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Medicinal Usage of Cannabis and Cannabinoids offers readers a comprehensive reference on the medical usage and symptom relief provided by these compounds in a variety of disorders. With coverage of neurological diseases like Alzheimer's and Parkinson's, and a wide range of other afflictions including depression, anxiety, nausea and cancer, this broad coverage allows readers to learn about symptom control, along with the physiological, psychological and pharmacological effects of these compounds. Unique case reports are provided as well. This volume provides a platform for research on the use of these compounds in improving patient care, brain function and neurological dysfunction. - Summarizes the medicinal usage of cannabis and cannabinoids in a variety of conditions - Contains chapter abstracts, key facts, a dictionary and a summary - Examines symptom control of conditions such as depression, anxiety and sleep - Discusses cannabis usage in Alzheimer's, Parkinson's, Multiple Sclerosis and cancer - Features case reports and chapters on the physiological, psychological and pharmacological effects
Perhaps the most important achievements in the field of epileptology in the past two decades have been in the neuroimaging and genetic breakthroughs as applied to patients with epilepsy. Indeed, neuroimaging has become a vital part in the study of epilepsy, affecting broad aspects of the disorder ranging from diagnosis and classification to treatment and prognosis. Neuroimaging in epilepsy encompasses many different approaches that have reached various levels of expertise across epilepsy centers worldwide. This book discusses every imaging modality used to gather information on epilepsy. Each technique is described by world experts and epilepsy centers worldwide.
Core Topics in Neuroanesthesia and Neurointensive Care is an authoritative and practical clinical text that offers clear diagnostic and management guidance for a wide range of neuroanesthesia and neurocritical care problems. With coverage of every aspect of the discipline by outstanding world experts, this should be the first book to which practitioners turn for easily accessible and definitive advice. Initial sections cover relevant anatomy, physiology and pharmacology, intraoperative and critical care monitoring and neuroimaging. These are followed by detailed sections covering all aspects of neuroanesthesia and neurointensive care in both adult and pediatric patients. The final chapter discusses ethical and legal issues. Each chapter delivers a state-of-the art review of clinical practice, including outcome data when available. Enhanced throughout with numerous clinical photographs and line drawings, this practical and accessible text is key reading for trainee and consultant anesthetists and critical care specialists.
Globally, natural medicine has been considered as an important alternative to modern allopathic medicine. Although natural medicines are popular in society, only limited medicinal herbs have been scientifically evaluated for their potential in medical treatment. This book connects various aspects of the complex journey from traditional medicine to modern medicine. It provides information on topics including global regulations and regulatory hurdles, diverse nutritional challenges and potential health benefits, novel food innovations especially seed-to-clinic approaches, and future trends. FEATURES • Provides information on sustainable use of natural products in the development of new drugs and clinically validated herbal remedies • Discusses issues on evaluation and clinical aspects of herbal medicine, promotion and development, safety evaluation, metabolite profiling, biomarker analysis, formulation, and stability testing • Describes traditional uses of natural medicine through identification, isolation and structural characterization of their active components • Elucidates mechanisms of biological action, adverse effects and identification of their molecular targets of natural medicine • Multidisciplinary appeal including chemistry, pharmacology, pharmacognosy and cell and molecular biology, as well as integration with clinical medicine This book serves as an essential guide for individuals researching natural medicines, and industry employees in areas including drug development, pharmacology, natural products chemistry, clinical efficacy, ethnopharmacology, pharmacognosy, phytotherapy, phyto-technology and herbal science.
Direct Nose-to-Brain Drug Delivery provides the reader with precise knowledge about the strategies and approaches for enhanced nose-to-brain drug delivery. It highlights the development of novel nanocarrier-based drug delivery systems for targeted drug delivery to the brain microenvironments with a focus on the technological advances in the development of the novel drug delivery devices for intranasal administration, including special emphasis on brain targeting through nose. This book explores the various quantification parameters to assess the brain targeting efficiency following intranasal administration and includes an overview on the toxicity aspects of the various materials used to develop the direct nose-to-brain drug delivery vehicles and of the regulatory aspects including patents and current clinical status of the potential neurotherapeutics for the effective management of neuro-ailments. Technological advances in new drug delivery systems with diverse applications in pharmaceutical, biomedical, biomaterials, and biotechnological fields are also explained. This book is a crucial source that will assist the veteran scientists, industrial technologists, and clinical research professionals to develop new drug delivery systems and novel drug administration devices for the treatment of neuro-ailments. - Explains the targeting approaches for enhanced brain targeting following intranasal drug administration - Explores the various nanocarriers developed to date for neurotherapeutic delivery via nose-to-brain - Discusses pharmaceutical and biomedical applications after nose-to-brain delivery of therapeutic pharmaceuticals and biologicals
Leading researchers address conceptual and technical issues in schizophrenia and suggest novel strategies for advancing research and treatment. Despite major advances in methodology and thousands of published studies every year, treatment outcomes in schizophrenia have not improved over the last fifty years. Moreover, we still lack strategies for prevention and we do not yet understand how the interaction of genetic, developmental, and environmental factors contribute to the disorder. In this book, leading researchers consider conceptual and technical obstacles to progress in understanding schizophrenia and suggest novel strategies for advancing research and treatment. The contributors address a wide range of critical issues: the construct of schizophrenia itself; etiology, risk, prediction, and prevention; different methods of modeling the disorder; and treatment development and delivery. They identify crucial gaps in our knowledge and offer creative but feasible suggestions. These strategies include viewing schizophrenia as a heterogeneous group of conditions; adopting specific new approaches to prediction and early intervention; developing better integration of data across genetics, imaging, perception, cognition, phenomenology, and other fields; and moving toward an evidence-based, personalized approach to treatment requiring rational clinical decision-making to reduce functional disability. Contributors Robert Bittner, Robert W. Buchanan, Kristin S. Cadenhead, William T. Carpenter, Jr., Aiden Corvin, Daniel Durstewitz, André A. Fenton, Camilo de la Fuente-Sandoval, Jay A. Gingrich, Joshua A. Gordon, Chloe Gott, Peter B. Jones, René S. Kahn, Richard Keefe, Wolfgang Kelsch, James L. Kennedy, Matcheri S. Keshavan, Angus W. MacDonald III, Anil K. Malhotra, John McGrath, Andreas Meyer-Lindenberg, Kevin J. Mitchell, Bita Moghaddam, Vera A. Morgan, Craig Morgan, Kim T. Mueser, Karoly Nikolich, Patricio O'Donnell, Michael O'Donovan, William A. Phillips, Wulf Rössler, Louis Sass, Akira Sawa, Jeremy K. Seamans, Steven M. Silverstein, William Spaulding, Sharmili Sritharan, Heike Tost, Peter Uhlhaas, Aristotle Voineskos, Michèle Wessa, Leanne M. Williams, Ashley Wilson, Til Wykes
Our understanding of dystonia is advancing rapidly. This comprehensive reference work provides an effective guide to this challenging group of disorders, offering an overview of the current and emerging treatment options for all manifestations. Treatments for the many forms of dystonia differ substantially in pediatrics and adults - both are covered in detail in this book. Approaches include botulinum toxin therapy, deep brain stimulation, oral drug applications, rehabilitation, and behavioral and experimental therapies. Special emphasis is also given to combining different treatment modalities in order to achieve optimal effect. Treatment of Dystonia brings together peer-reviewed articles, written by experts and based on work presented at international conferences. By enabling the physician to select and combine the best therapies, it is an essential resource for neurologists, neurosurgeons and physical therapists.