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The second edition of this book serves both as an introductory and reference book focusing on the field of metastatic bone disease. Featuring contributions from experts in the field, this volume describes the molecular and cellular mechanisms involved in the formation of bone metastases, presents the newer advances made in the understanding of the clinical picture and symptoms of patients, analyses the role of bone markers in research and clinical practice and deals with all aspects of imaging modalities applied for the detection and evaluation of bone metastases. Moreover, the use of all available treatment methods, such as radiotherapy, surgery and systemic treatments for the management of patients with metastatic bone disease is discussed in detail. Overall this volume presents a thorough overview of all aspects of metastatic bone disease and provides a comprehensive and concise information resource for researchers, oncologists, orthopaedic surgeons and clinicians dealing with patients with metastatic bone disease.
Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.
On March 2, 1994, the Agency for Health Care Policy and Research (a division of the Public Health Service) made headlines by releasing new cancer pain management guidelines. That report revealed that pain is frequently undertreated, and that relief is not only possible for most patients, but actually aids in recovery. For many cancer victims, the agency's guidelines offered new hope; for Dr. Richard B. Patt and coauthor Susan S. Lang, it was a resounding vindication of the findings they set forth in You Don't Have to Suffer. Written by one of the country's leading cancer pain experts and science writer Lang, You Don't Have to Suffer provides an invaluable, no-nonsense handbook for anyone with cancer, for anyone caring for a loved one with cancer, and for the doctors and nurses who treat these patients. The authors first illuminate the reasons why patients are so often undermedicated, including unfounded fears of addiction, patients thinking they need to tough it out, time-consuming paperwork for doctors who prescribe narcotics, and laws that fail to distinguish between drug abuse and the legitimate employment of narcotics. In a careful argument now taken up by the AHCPR's guidelines, Lang and Patt demonstrate that properly medicated patients are better able to resume active lives and marshall strength to fight their disease--while those in chronic pain not only suffer, but also may jeopardize their potential for recovery. You Don't Have to Suffer explores all the pain-relieving options available in the modern medical arsenal--from drugs and high-tech medical procedures to psychological and cognitive techniques and home nursing tips to make a patient more comfortable. Detailed chapters discuss the medications that can fight cancer pain or relieve the undesirable side effects of chemotherapy, radiation, surgery, and other cancer treatments; anaesthetic and neurosurgical options for pain that has not responded well to simpler techniques; ways to prevent or relieve constipation, nausea, drowsiness, and other complaints of cancer patients; and mind/body techniques and other ways of coping with depression and various psychological symptoms that contribute to the relief of suffering. Pulling together a wealth of long-needed information on the latest medical advances, You Don't Have To Suffer is a volume for the growing numbers of patients, family members, and health-care professionals who are determined to relieve needless cancer pain.
Drugs take strange journeys from the black market to the doctor's black bag. Changing marijuana laws in the United States and Canada, the opioid crisis, and the rising costs of pharmaceuticals have sharpened the public's awareness of drugs and their regulation. Government, industry, and the medical profession, however, have a mixed record when it comes to framing policies and generating knowledge to address drug use and misuse. In Strange Trips Lucas Richert investigates the myths, meanings, and boundaries of recreational drugs, palliative care drugs, and pharmaceuticals as well as struggles over product innovation, consumer protection, and freedom of choice in the medical marketplace. Scrutinizing how we have conceptualized and regulated drugs amid the pressing and competing interests of state regulatory bodies, pharmaceutical and for-profit companies, scientific researchers, and medical professionals, Richert asks how perceptions of a product shift – from dangerous substance to medical breakthrough, or vice versa. Through close examination of archival materials, accounts, and records, he brings substances into conversation with each other and demonstrates the contentious relationship between scientific knowledge, cultural assumptions, and social concerns. Weaving together stories of consumer resistance and government control, Strange Trips offers timely recommendations for the future of drug regulation.
* ·Comprehensive guide to all aspects of the control of acute and chronic pain due to cancer * · international authorship *