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This book represents a comprehensive description and evaluation of the most up-to-date approaches to cancer management. Each chapter, prepared by leading basic researchers and clinicians, provides an in depth description of a specific method for cancer management. The chemotherapy section of the book is updated to include the newest drugs as well as those currently in development. Organized by drug class, this section provides the latest information on most drugs, including their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The biological therapy section of the book provides expanded coverage of the currently used cytokines, vaccines, and cell based therapies of cancer. Full consideration is also given to other modern treatment approaches, such as tyrosine kinase inhibitors, inhibitors of tumor angiogenesis, and the transcatheter management of cancer. Current advances in hyperthermia in cancer treatment, hematologic and nutritional support, bone marrow transplantation, pain management and care of the terminally ill patients with cancer are also presented. In summary, this book provides a comprehensive coverage of the current knowledge on the most innovative, systematic and multidisciplinary approaches to the treatment of patients with cancer.
This volume, the last in this series on cancer growth and Moreover, the current status of plant-derived vinca alka progression, is a companion volume to Volume IX and loids and non-alkaloid natural products is summarized. further explores established and novel approaches for the Advances in hyperthermia and additional approaches for therapy of patients with malignant neoplasms. The stra the therapy of malignancies are also presented. tegies reflected in these volumes are direct extrapolations The volume continues with chapters on bone marrow from the basic science of cancer biology, growth and pro transplantation as well as hematologic and nutritional sup gression described in earlier volumes of this series. Some port for the cancer patient. Blood pressure in the cancer approaches are directed towards the eradication or modifi patient, therapy for nausea and vomiting as well as pain are cation of the properties of heterogeneous malignant tumor discussed. The last chapter is devoted to the problems of the cells at various stages of tumor progression, while other terminally ill, including evaluations of the burden relatives approaches are directed towards modification of the host and friends of the cancer patient have to bear. antitumor defense systems, e. g. , enhancement of host anti It is clear that important advances in the basic science of tumor immune reactivity.
This book aims to address the infusion sequence of the main protocols used in the treatment of varied solid cancers. Since an inadequate infusion sequence can compromise the patient's treatment, this work will provide support to professionals working in the field of oncology in assessing each chemotherapy infusion sequence. The introductory chapters present the definition, indication, and the risks and benefits of polypharmacy in cancer therapy, and discuss the importance of drug combination in cancer treatment. Chapter 2 focuses on the challenges and also the toxicity of combination therapy in cancer, while chapter 3 highlights the parameters that must be evaluated before defining the infusion sequence, such as pharmacodynamic and pharmacokinetic profiles, drugs’ stability when diluted or reconstituted, toxicological profile of each drug, among others. The remaining chapters are divided by type of cancer. The content is focused on solid tumors, dividing the chapters according to breast, gastrointestinal, genitourinary, gynecological, head and neck, lung, and neurological cancers. In each chapter the epidemiological profiles, pathophysiology, therapeutic modalities, and the main chemotherapy protocols are addressed, as well as efficacy studies and data on the infusion sequence of each mentioned protocol. This work will be a valuable resource to physicians, nurses, and pharmacists, and may help to improve health service practices.
GLOBAL EPIDEMIOLOGY OF CANCER Cancer is the second highest cause of death in the United States, and a leading cause of death globally. Our goals are to discuss the global epidemiology of various cancers, with detailed information on their prevalence, incidence, and clinical considerations. Epidemiology is the key to understanding the mortality and morbidity of cancer, and how we can prevent, diagnose, and treat the disease. Prevention of cancer is essential for saving lives. Prevalence and incidence of cancer are key factors that each government and population must be aware of. Advances in the study of cancer occur on a regular basis, and this book provides the latest insights about relationships between the disease and stem cells, tumorigenesis, molecular interactions, pathways, channels, and immunity. Global Epidemiology of Cancer: Diagnosis and Treatment meets the needs of readers by providing current information about epidemiology (including molecular epidemiology), diagnosis, and treatment. Providing logical, step-by-step information on various cancers, this book consolidates all of the most up-to-date information and data from verified studies on all different types of cancers in the United States and throughout the world. Chapters are presented so that each includes an overview, clinical manifestations, epidemiology, pathophysiology, etiology and risk factors, diagnosis, treatment, prevention, and prognosis. Global Epidemiology of Cancer: Diagnosis and Treatment will be invaluable to graduate and postgraduate students, including medical students; nurses; physician assistants; residents in oncology; public health students and allied health students.
Design, Fabrication, and Characterization of Multifunctional Nanomaterials covers major techniques for the design, synthesis, and development of multifunctional nanomaterials. The chapters highlight the main characterization techniques, including X-ray diffraction, scanning electron microscopy, high-resolution transmission electron microscopy, energy dispersive X-ray spectroscopy, and scanning probe microscopy.The book explores major synthesis methods and functional studies, including: - Brillouin spectroscopy; - Temperature-dependent Raman spectroscopic studies; - Magnetic, ferroelectric, and magneto-electric coupling analysis; - Organ-on-a-chip methods for testing nanomaterials; - Magnetron sputtering techniques; - Pulsed laser deposition techniques; - Positron annihilation spectroscopy to prove defects in nanomaterials; - Electroanalytic techniques. This is an important reference source for materials science students, scientists, and engineers who are looking to increase their understanding of design and fabrication techniques for a range of multifunctional nanomaterials. - Explains the major design and fabrication techniques and processes for a range of multifunctional nanomaterials; - Demonstrates the design and development of magnetic, ferroelectric, multiferroic, and carbon nanomaterials for electronic applications, energy generation, and storage; - Green synthesis techniques and the development of nanofibers and thin films are also emphasized.
Nanostructures for Cancer Therapy discusses the available preclinical and clinical nanoparticle technology platforms and their impact on cancer therapy, including current trends and developments in the use of nanostructured materials in chemotherapy and chemotherapeutics. In particular, coverage is given to the applications of gold nanoparticles and quantum dots in cancer therapies. In addition to the multifunctional nanomaterials involved in the treatment of cancer, other topics covered include nanocomposites that can target tumoral cells and the release of antitumoral therapeutic agents. The book is an up-to-date overview that covers the inorganic and organic nanostructures involved in the diagnostics and treatment of cancer. - Provides an examination of nanoparticle delivery systems for cancer treatment, illustrating how the use of nanotechnology can help provide more effective chemotherapeutic treatments - Examines, in detail, the different types of nanomaterials used in cancer therapy, also explaining the effect of each - Provides a cogent overview of recent developments in the use of nanostructured materials in chemotherapeutics, allowing readers to quickly familiarize themselves with this area
This is the third volume of the Patent eBook Series entitled Topics in Anti-Cancer Research. This eBook comprises updated reviews on topics relevant to modern cancer research published in the journal Recent Patents on Anti-Cancer Drug Discovery. The comprehensive range of themes covered in this third volume will be of benefit to clinicians, scientists and R&D experts looking for new targets for the prevention of cancer and discovery of drugs for the treatment of different cancer types. Regulation of tumor cells by TRAIL receptors, development of anti- cancer drugs & immunomodulatory drugs, molecular studies of adrenocortical cancer, role of inhibitors of inosine monophosphate dehydrogenase in cancer, recent updates in glioblastoma stem cells, latest approaches for cancer gene therapy and metabolic therapy for cancer were reviewed and updated. The role of pH regulation and application of hyperthermia, thiosemicarbazone derivatives, tamoxifen-based therapies for cancer treatment andproteome-based complex therapy of tumors, calcium signaling and angiogenesis, antineoplastic role of GHRH antagonists and therapeutic applications in human tumors and clinical oncology have been extensively discussed in the light of recent innovations. The topics covered in this third volume will be valuable for those interested in scientists interests in methods for the prevention of cancer as well its management.
This book is an educational resource of evolving scientific knowledge in the area of bioelectromagnetics that may serve the interests of students and decision-makers, as well as society as a whole. It is distinguished by extensive descriptions of fundamental biophysical concepts and their relevance to human health. Reflecting the transdisciplinary approach from several different intellectual streams including physics, biology, epidemiology, medicine, environment, risk science, and engineering, the book is quite a venture into the battling studies to assess the latest research on health effects and biomedical applications of EM energy. This new edition of the book particularly looks at the potential threats from the emerging 5G wireless networks, which will deploy large numbers of low-powered smartphones, notebooks, tablets, radio access networks, and other transmitters. Features Introduces necessary biophysical principles of EM fields in the context of their interaction with living systems. Strengthens understanding of cutting-edge research on several major areas in the broad area of bioelectromagnetics. Presents safety standards and guidelines for human exposure to EM fields. Discusses techniques that have been developed to ensure adequate EM-thermal dosimetry required for both health effects and biomedical applications. Provides insight into the determinants of EM health risk assessment and public concerns. Includes extensive reference list at the end of each chapter to enhance further study. Riadh Habash is a special appointment professor and McLaughlin Research Chair in Electromagnetic Fields and Health at the University of Ottawa, Canada. He has been the recipient of many awards, including the National Wighton Fellowship Award, and has authored or co-authored over 90 research articles, six books, and five book chapters. His most recent books are Green Engineering in 2017 and Professional Practice in 2019 (CRC Press), with the remaining previous books targeting the area of bioelectromagnetics.
Of the interaction and relationship of both systems is chal In this volume, aspects of neoplastic spread, already elu cidated in Volumes I-IV of this series, are considered lenging indeed. against a broad biological background. The mammalian The volume also reviews environmental oncology and species-specific aspects of environmental chain reactions. It orders constituting the logical framework for man as focal point of a comparative oncology are reviewed. Selected is apparent that the environment plays a significant role in examples of neoplastic progression in various taxonomic the development of neoplasms. Neoplasms among the spe units are provided, beginning with the opposite pole of ci es have become much more common as a result of man's taxonomic development, the vascular plants, where no impact on the environment. The latter chapters present a metastatis of malignant neoplasms occur. Among in brief review of geologic and technologic and cuItural vertebrates, vertebrates, and vascular plants, Iining mem changes, and the implications of species-specific cancer pro branes (epithelia) exhibit the highest degree of comparabil gression. The remainder of this section outlines a number of ity. Metastases also occur, but more rarely, in invertebrates; selected chain reactions leading to neoplastic development and are discussed as they are found in the nonmammalian in certain members of these chains. A discussion of the vertebrates: in fish, amphibians, reptiles, and birds. Diseases storage of chemical carcinogens in plants and their interac ofthe leukemia (Ieucosis)-Iymphoma complex are present in tion with other causes of neoplastic growth is also included.