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Classical conditioning (CC) refers to the general paradigm for scientific studies of learning and memory, as initiated by Pavlov and his followers. Despite the current high level of interest in CC within neuroscience there is presently no single source that provides up-to-date comprehensive coverage of core topics. CC is a very large field. Nevertheless, some organisms and behaviors have dominated the neuroscience scene. Foremost of these are classical eyeblink conditioning (rats, cats, rabbits, and humans) and ear'conditioning. This handbook of CC focuses on these systems. It will be particularly appealing to the growing amount of scientists and medical specialists who employ CC methods.'
Since Pavlov, physiologists have explained homeostasis—the regulation of bodily functions—as the action of fixed negative feedback networks within individual organ systems. However, these standard explanations largely ignore the mechanisms of conditioning and learning. Drawing on the work of Western, East European, and Russian physiologists, Barry R. Dworkin challenges traditional concepts and argues that learning mechanisms of the nervous system are essential to regulation. Dworkin shows how, through experience, learning mechanisms determine dynamic stability and the long-term regulation of heart rate, blood pressure, glucose, electrolytes, and temperature. He argues that "hard wired" mechanisms do not adequately account for the speed and accuracy of physiological adjustments, and supports his contention with detailed analyses and mathematical models of how conditioned and unconditioned reflexes interact. Dworkin reviews a wealth of research on interoceptive conditioning, conditioned drug responses, and visceral adjustment. Combining physiological and behavioral data with mathematical analysis and computer models, he synthesizes the work of Pavlov and W. B. Cannon in a quantitative theory of physiological regulation that will interest researchers and theorists in medicine, physiology, neuroscience, and biopsychology.
The model system of eyeblink classical conditioning in humans has enormous potential for the understanding and application of fundamental principles of learning. This collection makes classical conditioning accessible to teachers and researchers in a number of ways. The first aim is to present the latest developments in theory building. Second, as background for the current directions, Eyeblink Classical Conditioning, Volume I presents an overview of a large body of previously published research on eyeblink classical conditioning. Last, the authors describe eyeblink classical conditioning techniques. Each chapter includes a highlighted methods section so that interested readers can replicate techniques for teaching and research.
The present day is witnessing an explosion of our understanding of how the brain works at all levels, in which complexity is piled on complexity, and mechanisms of astonishing elegance are being continually discovered. This process is most developed in the major areas of the brain, such as the cortex, thalamus, and striatum. The Claustrum instead focuses on a small, remote, and, until recently, relatively unknown area of the brain. In recent years, researchers have come to believe that the claustrum is concerned with consciousness, a bold hypothesis supported by the claustrum's two-way connections with nearly every other region of the brain and its seeming involvement with multisensory integrations—the hallmark of consciousness. The claustrum, previously in a humble position at the back of the stage, might in fact be the conductor of the brain's orchestra. The Claustrum brings together leading experts on the claustrum from the varied disciplines of neuroscience, providing a state-of-the-art presentation of what is currently known about the claustrum, promising lines of current research (including epigenetics), and projections of new lines of investigation on the horizon. - Develops a unifying hypothesis about the claustrum's role in consciousness, as well as the integration of sensory information and other higher brain functions - Discusses the involvement of the claustrum with autism, schizophrenia, epilepsy, Alzheimer's disease, and Parkinson's disease - Coverage of all aspects of the claustrum, from its evolution and development to promising new lines of research, including epigenetics, provides a platform and point of reference for future investigative efforts
Classical conditioning of the nictitating membrane (NM) eyeblink response in rabbits is a useful model system for the study of the neurobiology of learning and memory. This paradigm that is so well described on a biological level has also been applied to studies of normal development over the life span and to instances of abnormal developmental phenomena. Eyeblink conditioning has been studied from molecular and neural network perspectives, and the paradigm is of demonstrated utility in elucidating mechanisms in physiology and pharmacology. This model system provides a behavioral paradigm in animals that has a close analog in human behavior. Perspectives of recent developments in human eyeblink classical conditioning research are presented in the companion volume to this book, Eyeblink Classical Conditioning: Applications in Humans.
The Oxford Textbook of Neurocritical Care provides an authoritative and up-to-date summary of the scientific basis, clinical techniques and management guidelines in this exciting clinical discipline. Authored by an international team of expert practitioners this textbook reflects world-wide practice.